IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus

TGF-β Blood Levels Distinguish Between Influenza A (H1N1)pdm09 Virus Sepsis and Sepsis due to Other Forms of Community-Acquired Pneumonia

“…However, other influenza viruses in the group of non-(H1N1)pdm09 pneumonia patients were not tested (42,43). IL-17 has been associated with acute lung injury in influenza A (H1N1)pdm09 patients (24). High levels were also detected in patients in the present study.…”

“…However, their role in hypercytokinemia during influenza virus infection has not been studied. Several groups have reported their findings, and the role of IL-6 seems to be the common feature among influenza A (H1N1)pdm09-infected patients (1,11,33), while local variations seem to correlate with higher levels of other cytokines, such as IL-10 or IL-17 (24,43). Because of this, the objective in the present study was to analyze cytokine levels in patients with influenza A (H1N1)pdm09 infection, in addition to clinical severity scores, and blood chemistry.…”

Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury

“…During the 2009 swine flu pandemic, we recruited dozens of patients who were PCR positive for the 2009 S-OIV H1N1 and 9 patients with normal upper respiratory tract infections from two hospitals in Beijing, China [11]. We performed a Bio-plex cytokine assay on the serum samples from 23 qualified patients.…”

“…We created an ALI model in mice infected with the A/Beijing/501/2009 (H1N1) (BJ501) strain isolated in China during the 2009 pandemic [11]. We measured the concentration of IP-10 in the bronchoalveolar lavage fluid (BALF) of BJ501 strain-infected wild-type (WT) mice and found that the IP-10 level was also significantly increased (Supplementary information, Figure S1A), confirming the important role of IP-10 in mediating ALI induced by 2009 S-OIV H1N1 infection.…”

Puerarin attenuates smoke inhalation injury by regulation of Th1/Th2 expression and inhibition of Th17 cells in rats

“…In addition, T helper cell type 17 (Th17) represents a recently identified T helper cell lineage and exerts biological functions by mainly producing IL-17A. Studies revealed that IL-17A could act as a pro-inflammatory cytokine and may play an important role in acute lung injury induced by lipopolysaccharide and H1N1 influenza virus [7,8]. Moreover, Bordetella pertussis could promote a mixed Th1/Th17 polarization by reducing Th1 immunity and increasing Th17 response and thereby enhancing lung inflammation and injury [9].…”