Opposing roles of IL-10 in acute bacterial infection

Peñaloza, Hernán F.; Schultz, Bárbara M.; Nieto, Pamela A.; Salazar, Geraldyne A.; Suazo, Isidora D.; González, Pablo A; Riedel, Claudia A.; Álvarez-Lobos, Manuel; Kalergis, Alexis M.; Bueno, Susan M.

doi:10.1016/j.cytogfr.2016.07.003

Cited by 64 publications

(53 citation statements)

References 198 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increasing the levels of IL‐10 in the positive control is known as an anti‐inflammatory impact that decreases inflammatory immune responses. The result closely agrees with Peñaloza et al (), who reported that IL10 induction may enhance the host's immune system to specific bacteria when antibiotics are not absolutely effective. They also recommended that IL‐10 boosts the inhibition of the immune response as affected by infection with non‐inflammatory bacterial infections or intracellular bacteria that supports bacterial perseverance and dissemination in the host.…”

Section: Resultssupporting

confidence: 92%

Immunomodulatory effect of papaya ( Carica papaya ) pulp and seed extracts as a potential natural treatment for bacterial stress

et al. 2019

View full text Add to dashboard Cite

The current study evaluated the immunomodulatory effects of Carica papaya pulp and seeds methanol (MeOH) extracts on mice infected with Listeria monocytogenes. Gas chromatography–mass spectrometry analysis identified 10 active constituents in C. papaya seed MeOH extract and 10 compounds in C. papaya pulp MeOH extract. The experimental animals were divided into negative control (G1) group, positive control (G2) group, pulp extract treated (G3) group, and seed extract treated (G4) group. After infection of animals (G2, G3, and G4), treatments were started for 3 weeks. Estimation of the immunological parameters showed a marked decrease in IgM levels and an increase in IgG levels in the treated groups (G3 and G4) compared with those in G2. The proinflammatory cytokines (IL‐10, IL‐12, IL‐1β, IL‐6, and TGF‐β1) were decreased in the treated groups (G3 and G4) compared with those in G2. Nitric oxide levels were also decreased, and the percentages of phagocytosis increased compared with those of G2. The results demonstrated the immunomodulatory and anti‐inflammatory effects of C. papaya pulp and seeds MeOH extracts. Practical applications Based on the antioxidant and antibacterial activities exhibited by the pulp and seed MeOH extracts investigated in this study, Carica papaya might be considered as a natural source of phytochemicals that could be utilized in novel foods and pharmaceuticals. Further investigation are needed to identify and purify compounds that might be responsible for the observed effects.

show abstract

Section: Resultssupporting

confidence: 92%

Immunomodulatory effect of papaya ( Carica papaya ) pulp and seed extracts as a potential natural treatment for bacterial stress

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The kinetics of IL-10 production and the cellular source of IL-10 are also major differences between pneumonia caused by CRKP-ST258 and that caused by other pathogens. IL-10 production is induced in myeloid cells after PAMP recognition by pattern recognition receptors (PRRs) (11). In this scenario, any leukocyte may potentially produce IL-10.…”

Section: Discussionmentioning

confidence: 99%

“…Each subset shares the same surface markers of their proinflammatory counterparts (inflammatory monocytes, neutrophils, and eosinophils, respectively) but also expresses antiinflammatory mediators able to inhibit T cell function and proliferation, such as arginase-1, inducible nitric oxide synthase (iNOS), and interleukin-10 (IL-10) (9). IL-10 is a major anti-inflammatory cytokine produced by nearly all leukocytes, with widely suppressive effects on several immune cell types (11). During bacterial infections, IL-10 modulates the proinflammatory immune response, allowing clearance of the pathogen with reduced tissue damage (12).…”

mentioning

confidence: 99%

Interleukin-10 Produced by Myeloid-Derived Suppressor Cells Provides Protection to Carbapenem-ResistantKlebsiella pneumoniaeSequence Type 258 by Enhancing Its Clearance in the Airways

et al. 2019

Self Cite

View full text Add to dashboard Cite

Carbapenem-resistant Klebsiella pneumoniae sequence type 258 (CRKP-ST258) can cause chronic infections in lungs and airways, with repeated episodes of bacteremia. In this report we addressed whether the recruitment of myeloid cells producing the anti-inflammatory cytokine interleukin-10 (IL-10) modulates the clearance of CKRP-ST258 in the lungs and establishes bacterial persistence. Our data demonstrate that during pneumonia caused by a clinical isolate of CRKP-ST258 (KP35) there is an early recruitment of monocyte-myeloid-derived suppressor cells (M-MDSCs) and neutrophils that actively produce IL-10. However, M-MDSCs were the cells that sustained the production of IL-10 over the time of infection evaluated. Using mice unable to produce IL-10 (IL-10 Ϫ/Ϫ ), we observed that the production of this cytokine during the infection caused by KP35 is important to control bacterial burden, to prevent lung damage, to modulate cytokine production, and to improve host survival. Importantly, intranasal transfer of bone marrow-derived M-MDSCs from mice able to produce IL-10 at 1 day prior to infection improved the ability of IL-10 Ϫ/Ϫ mice to clear KP35 in the lungs, decreasing their mortality. Altogether, our data demonstrate that IL-10 produced by M-MDSCs is required for bacterial clearance, reduction of lung tissue damage, and host survival during KP35 pneumonia.

show abstract

“…IL‐10 has anti‐inflammatory properties but showed the same pattern as the pro‐inflammatory cytokines in this study. IL‐10 is believed to play an important role in balancing the inflammatory response in order to limit host tissue damage . For example, compared to wild‐type mice, IL‐10–deficient mice demonstrate more efficient bacterial clearance but higher mortality and increased neutrophil recruitment to the lung in response to Streptococcus pneumoniae infection, which underscores the regulatory role of IL‐10 during infection.…”

Section: Discussionmentioning

confidence: 99%

Heparin-binding protein, lysozyme, and inflammatory cytokines in bronchoalveolar lavage fluid as diagnostic tools for pulmonary infection in lung transplanted patients

Aspelund

Hammarström

Inghammar

et al. 2018

American Journal of Transplantation

View full text Add to dashboard Cite

Pulmonary infection is a common complication after lung transplantation, and early detection is crucial for outcome. However, the condition can be clinically difficult to diagnose and to distinguish from rejection. The aim of this prospective study was to evaluate heparin‐binding protein (HBP), lysozyme, and the cytokines interleukin (IL)‐1β, IL‐6, IL‐8, IL‐10 and tumor necrosis factor (TNF) in bronchoalveolar lavage fluid (BALF) as potential biomarkers for pulmonary infection in lung‐transplanted patients. One hundred thirteen BALF samples from 29 lung transplant recipients were collected at routine scheduled bronchoscopies at 3 and 6 months, or on clinical indication. Samples were classified into no, possible, probable, or definite infection at the time of sampling. Rejection was defined by biopsy results. HBP, lysozyme, and cytokines were analyzed in BALF and correlated to likelihood of infection and rejection. All biomarkers were significantly increased in BALF during infection, whereas patients with rejection presented low levels that were comparable to noninfection samples. HBP, IL‐1β, and IL‐8 were the best diagnostic markers of infection with area under the receiver‐operating characteristic curve values of 0.88, 0.91, and 0.90, respectively. In conclusion, HBP, IL‐1β, and IL‐8 could be useful diagnostic markers of pulmonary infection in lung‐transplanted patients.

show abstract

Opposing roles of IL-10 in acute bacterial infection

Cited by 64 publications

References 198 publications

Immunomodulatory effect of papaya ( Carica papaya ) pulp and seed extracts as a potential natural treatment for bacterial stress

Immunomodulatory effect of papaya ( Carica papaya ) pulp and seed extracts as a potential natural treatment for bacterial stress

Interleukin-10 Produced by Myeloid-Derived Suppressor Cells Provides Protection to Carbapenem-ResistantKlebsiella pneumoniaeSequence Type 258 by Enhancing Its Clearance in the Airways

Heparin-binding protein, lysozyme, and inflammatory cytokines in bronchoalveolar lavage fluid as diagnostic tools for pulmonary infection in lung transplanted patients

Contact Info

Product

Resources

About