Opportunities in posthemorrhagic hydrocephalus research: outcomes of the Hydrocephalus Association Posthemorrhagic Hydrocephalus Workshop

Abstract

The Hydrocephalus Association Posthemorrhagic Hydrocephalus Workshop was held on July 25 and 26, 2016 at the National Institutes of Health. The workshop brought together a diverse group of researchers including pediatric neurosurgeons, neurologists, and neuropsychologists with scientists in the fields of brain injury and development, cerebrospinal and interstitial fluid dynamics, and the blood–brain and blood–CSF barriers. The goals of the workshop were to identify areas of opportunity in posthemorrhagic hydrocephalus research and encourage scientific collaboration across a diverse set of fields. This report details the major themes discussed during the workshop and research opportunities identified for posthemorrhagic hydrocephalus. The primary areas include (1) preventing intraventricular hemorrhage, (2) stopping primary and secondary brain damage, (3) preventing hydrocephalus, (4) repairing brain damage, and (5) improving neurodevelopment outcomes in posthemorrhagic hydrocephalus.

Rh-IFN-α attenuates neuroinflammation and improves neurological function by inhibiting NF-κB through JAK1-STAT1/TRAF3 pathway in an experimental GMH rat model

“…The incidence of GMH is approximately 50% in preterm infants between 24 and 30 weeks of gestation (Lekic et al, 2012;Koschnitzky et al, 2018). The newborn rat has neurodevelopmental similarities to preterm humans at 24-26 weeks.…”

“…Germinal matrix hemorrhage (GMH) is a devastating neonatal stroke, of which the complications include neuroinflammation, hydrocephalus, primary and secondary brain injury and developmental delay (Koschnitzky et al, 2018). Among all of the complications, the activation of inflammatory cascades could be the main contributing factor of a series of post-hemorrhagic consequences, such as long term morphological and functional impairment (Zhang et al, 2018;Feng Z et al, 2017).…”

Gravitational shunt valves in hydrocephalus to challenge the sequelae of over-drainage

“…The leading reasons for shuntrevision are infection (1.7 to 34%) and shunt obstruction (3.1 to 21%) [46][47][48][49]. A higher incidence of shunt issues is predominantly seen in pediatric patients [50,51]. Studies on secondary hydrocephalus were mainly conducted to compare adjustable and non-adjustable valves [47,48,50,52].…”

Intraventricular Hemorrhages of Newborns, Causes, Complications and Prevention Methods

“…Тривають нові клінічні дослідження, одним з них є -використання мезенхімальних стовбурових клітин пуповиної крові у недоношених дітей з ВШК ІІІ-ІV ступенів, аналізуються відстрочені результати [13].…”