Opiorphin levels in fluids of burning mouth syndrome patients: a case-control study

Boucher, Yves; Dufour, Evelyne; Agbo-Godeau, Scarlette; Baaroun, Vanessa; Descroix, Vianney; Guinnepain, M.T.; Ungeheuer, Marie‐Noëlle; Ottone, Catherine; Rougeot, Catherine

doi:10.1007/s00784-016-1991-0

Cited by 29 publications

(56 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The gene products of opiorphin are posttranslationally processed to peptides that are released into the bloodstream; therefore the association between upregulated opiorphin gene expression and PrCa suggests that determining the levels of opiorphin peptides in the blood may be useful as a prognostic marker. Several studies have already demonstrated the measurement of opiorphin levels in blood, saliva and seminal fluid and showed that opiorphin levels could be prognostic markers of disease (e.g., burning mouth syndrome [ 44 ], dental pain [ 45 ] and male factor infertility [ 46 ]).…”

Section: Discussionmentioning

confidence: 99%

Role of Opiorphin Genes in Prostate Cancer Growth and Progression

et al. 2021

View full text Add to dashboard Cite

Background: We describe the first studies investigating a role for opiorphin genes ( PROL1, SMR3A and SMR3B) in prostate cancer (PrCa). Materials & methods: Databases and PrCa tissue arrays were screened for opiorphin expression. Xenografted tumor growth of human PrCa cells overexpressing PROL1 was compared with controls in nude mice. Modulated gene expression by overexpression of PROL1 was determined by RNA sequencing. Results: PrCa is associated with overexpression of opiorphin genes. Xenografted androgen-sensitive PrCa cells overexpressing PROL1 developed into tumors in castrated male mice (in contrast to parental cells). PROL1 overexpression modulates expression of genes in angiogenesis, steroid and hypoxic response pathways. Conclusions: Opiorphins promote the development of androgen-insensitive PrCa and activate pathways that potentially overcome the hypoxic barrier generated during tumor growth.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of Opiorphin Genes in Prostate Cancer Growth and Progression

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Downregulation of DMBT1 impairs epithelial differentiation and cellular defense mechanisms, whereas the reduction of LACRT may account for the reduced tears secretion in patients with dry eye ( 96 ). The reduction of PROL1 affects the paracrine or autocrine pathway of the lacrimal system ( 97 ). The ALDH3A1 protein protects against the oxidative stress of toxic radicals on the corneal surface ( 98 ).…”

Section: Putative Protein Markers In Tear Fluidmentioning

confidence: 99%

Critical role of mass spectrometry proteomics in tear biomarker discovery for multifactorial ocular diseases (Review)

et al. 2021

View full text Add to dashboard Cite

The tear film is a layer of body fluid that maintains the homeostasis of the ocular surface. The superior accessibility of tears and the presence of a high concentration of functional proteins make tears a potential medium for the discovery of non-invasive biomarkers in ocular diseases. Recent advances in mass spectrometry (MS) have enabled determination of an in-depth proteome profile, improved sensitivity, faster acquisition speed, proven variety of acquisition methods, and identification of disease biomarkers previously lacking in the field of ophthalmology. The use of MS allows efficient discovery of tear proteins, generation of reproducible results, and, more importantly, determines changes of protein quantity and post-translation modifications in microliter samples. The present review compared techniques for tear collection, sample preparation, and acquisition applied for the discovery of tear protein markers in normal subjects and multifactorial conditions, including dry eye syndrome, diabetic retinopathy, thyroid eye disease and primary open-angle glaucoma, which require an early diagnosis for treatment. It also summarized the contribution of MS to early discovery by means of disease-related protein markers in tear fluid and the potential for transformation of the tear MS-based proteome to antibody-based assay for future clinical application.

show abstract

“…However, the direct role of opiorphin in BMS is not supported although its blood levels may indicate a systemic deregulation in these patients. [18][19][20]…”

Section: And Therapeutic Implicationmentioning

confidence: 99%

An analgesic to bridge the gap between Narcotics and NSAIDs: opiorphin

Sujatha¹,

Priyadharshini²,

Nejad³

et al. 2018

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Pain management is an all-time challenge in dentistry. Discontent to pain management is a concern among patients and professionals. Unrelieved pain affects physical and mental well-being contributing to delayed recovery, psychological distress and anxiety. Studies have revealed that chronic pain interferes with normal daily chores of the individual like exercise, sleep, social life and lifestyle. At one end of pain management spectrum are Non-steroidal anti-inflammatory drugs (NSAIDs) while at the other end are the opioids. These drugs are not without constituent side effects. The quest is for new analgesics with potent and long term analgesia with minimal or no side effects. An analgesic that is intermediate in this spectrum is the need of the hour. Opiorphin is an endogenous peptide isolated from human saliva. Opiorphin produces analgesia, by inhibiting enkephalin (ENK) metabolizing enzymes, thus increasing the half-life of circulating ENKs. Apart from being a potent analgesic it can also be a potential biomarker for various systemic and psychosocial disorders. This review focuses on the pharmacological effects of opiorphin and its potential role as a biomarker in various disease conditions.

show abstract

Opiorphin levels in fluids of burning mouth syndrome patients: a case-control study

Cited by 29 publications

References 34 publications

Role of Opiorphin Genes in Prostate Cancer Growth and Progression

Role of Opiorphin Genes in Prostate Cancer Growth and Progression

Critical role of mass spectrometry proteomics in tear biomarker discovery for multifactorial ocular diseases (Review)

An analgesic to bridge the gap between Narcotics and NSAIDs: opiorphin

Contact Info

Product

Resources

About