Opioid Prescribing Patterns and Costs in a Large Group of Patients in Colombia

Machado‐Alba, Jorge Enrique; Gaviria‐Mendoza, Andrés; Vargas-Mosquera, Camila A.; Gil-Restrepo, Andrés Felipe

doi:10.1080/15360288.2016.1276504

Cited by 9 publications

(8 citation statements)

References 29 publications

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“…There are also reports showing that the greater and less-controlled inflammatory activity results in more pain [ 16 , 21 ]. Therefore, the association with the use of systemic corticosteroids may be related to the increased inflammatory activity in the group of patients with RA who required opioids [ 10 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Trends in Opioid Use in a Cohort of Patients with Rheumatoid Arthritis

Machado‐Duque

Ramírez-Valencia

Murillo‐Muñoz

et al. 2020

Pain Research and Management

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The objective was to determine the trend in the use of opioid analgesics in a cohort of patients diagnosed with and treated for rheumatoid arthritis (RA) in 24 cities in Colombia. This retrospective cohort study included adult patients diagnosed with RA, which was managed in a specialized institution in Colombia between January 2011 and December 2012. The first rheumatology visit was recorded as an index date, and monthly monitoring of the analgesic medication received was performed until December 2017. Sociodemographic variables, the use of opioids, and concomitant prescriptions were evaluated. A total of 1,329 patients diagnosed with and treated for RA were included; they had a mean age of 61.2 ± 11.8 years and were predominantly females (n = 936; 82.9%). A total of 1,129 (84.9%) subjects used opioids for at least one month, and a growing trend, from 13.5% to 21.4%, was observed in patients who received opioids every month throughout a 7-year follow-up of the cohort. In total, 46.7% of the cases used opioids for more than 12 months. The most commonly used opioids were codeine (76.3%) and tramadol (71.1%). All patients received conventional disease-modifying antirheumatic drugs (DMARDs), 85.6% received systemic corticosteroids, 73.9% received nonsteroidal anti-inflammatory drugs, and 15.9% received biological DMARDs. A high proportion of opioid use was shown for pain management in patients with RA, in many cases for more than 12 months, in whom the efficacy and especially safety, related to the risk of dependence, should be monitored.

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Section: Discussionmentioning

confidence: 99%

Trends in Opioid Use in a Cohort of Patients with Rheumatoid Arthritis

Machado‐Duque

Ramírez-Valencia

Murillo‐Muñoz

et al. 2020

Pain Research and Management

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“…In addition, a lack of dose increases in the usual management of these patients has been previously reported, possibly due to difficulties associated with poor tolerability or explained by proper prescription behaviors of the treating physicians. We were unable to rule out that the patients were in a gradual process of increasing the dose to reach optimal management [11,28].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Treatment Patterns and Direct Costs Associated with the Management of Neuropathic Pain

Machado‐Duque

Gaviria‐Mendoza

Machado‐Alba

et al. 2020

Pain Research and Management

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Background. Neuropathic pain has a prevalence of 2–17% in the general population. Diagnosis and treatment of neuropathic pain are not fully described in different populations. The aim was to determine the treatment patterns and direct costs of care associated with the management of neuropathic pain from the onset of the first symptom to up to two years after diagnosis. Methods. From a drug-claim database, a cohort of randomly selected outpatients diagnosed with neuropathic pain was obtained from an insurer in Colombia and followed up for two years after diagnosis. The clinical records were reviewed individually to identify the study variables, including the time needed to make the diagnosis, the medical and paraclinical resources used, the pharmacological therapy for pain management, and the direct costs associated with care. Results. We identified 624 patients in 49 cities, with a mean age of 50.3 ± 14.1 years, of which 324 were men (51.9%). An average of 90 days passed from the initial consultation until the diagnosis of neuropathic pain, the most frequent being lumbosacral radiculopathy (57.9%). 34.5% of the cohort had at least one diagnostic imaging procedure, and 16% had an electromyography. On average, they were treated by a general practitioner twice. 91.7% received initial treatment with tramadol, carbamazepine, amitriptyline, imipramine, or pregabalin, and 60.4% received combined therapy. The mean cost of care for two years for each patient was US$246.3. Conclusions. Patients with neuropathic pain in Colombia are being diagnosed late, are using therapeutic agents not recommended as first-line treatment by clinical practice guidelines, and are being treated for short periods of time.

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“…In one of the studies slightly more than 40% of respondents took biological DMARDs, 27% took glucocorticosteroids and almost 18% took antidepressants 21 . To this list other studies add the frequent use of benzodiazepines, antiepileptic drugs 26 and the use of non-opioid analgesics such as acetaminophen or NSAIDs 28 .…”

Section: Opioids and Rheumatoid Arthritismentioning

confidence: 99%

Different aspects of opioid use in rheumatoid arthritis patients

Sokół

Undziakiewicz

Dudek

et al. 2020

J Educ Health Sport

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Background: Rheumatoid arthritis (RA), chronic severe non-cancer pain and the use of prescription opioids are now an increasing and common problem. Both RA and its comorbid pain have different mechanisms and their control can prove challenging, especially when patients are unresponsive to non-opioid analgesics or have side effects. The aim of the study is to analyze the available results of research and meta-analyzes on the use of opioids among patients with rheumatoid arthritis. Materials and methods: the literature available on the PubMed platform and published between 2010 and 2020 was analyzed. Results and conclusions: The use of opioids can cause a number of side effects, including misuse, abuse or addiction to these drugs. These phenomena are becoming more common in European and North American populations, as well as more and more people are using

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Opioid Prescribing Patterns and Costs in a Large Group of Patients in Colombia

Cited by 9 publications

References 29 publications

Trends in Opioid Use in a Cohort of Patients with Rheumatoid Arthritis

Trends in Opioid Use in a Cohort of Patients with Rheumatoid Arthritis

Evaluation of Treatment Patterns and Direct Costs Associated with the Management of Neuropathic Pain

Different aspects of opioid use in rheumatoid arthritis patients

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