Opioid-free anaesthesia in three dogs

White, Donna M.; Mair, Alastair; Martínez-Taboada, Fernando

doi:10.4314/ovj.v7i2.5

Cited by 30 publications

(27 citation statements)

References 46 publications

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“…Abdominal wall closure appears to exert a major surgical stimulus. The abdominal wall is richly innervated by branches of the spinal nerves T7 – L3 and loco-regional anaesthesia in the form of a transverse abdominis plane (TAP) block has been shown to be an effective analgesic adjunct for abdominal surgery in cats and dogs [62–64].…”

Section: Discussionmentioning

confidence: 99%

Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs

Kropf

Hughes

2018

Ir Vet J

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BackgroundA prospective, randomized, placebo-controlled, blinded clinical study was conducted to determine whether a single dose of midazolam affects the cardiovascular response to surgical manipulation of the ovaries during elective ovariohysterectomy. Thirty-nine client-owned dogs undergoing elective ovariohysterectomy were recruited. After scoring cage demeanour, dogs were premedicated with acepromazine (0.03 mg kg-1) and pethidine (3 mg kg-1) intramuscularly into the quadriceps muscle and 20 min later sedation was scored. Anaesthesia was induced with propofol intravenously (IV) to effect. The study treatment (group M: midazolam (0.25 mg kg-1); or group P: placebo (Hartmann’s solution) (0.125 ml kg-1)) was administered IV before the intra-operative manipulation of the first ovary. Anaesthesia was maintained with isoflurane in oxygen. Morphine (0.3 mg kg-1 IV) was administered prior to the start of surgery. The vaporizer setting was adjusted according to the depth of anaesthesia. If an end-tidal isoflurane concentration (FE’Iso) above 1.6% was required additional analgesia was provided with fentanyl (2 μg kg-1). Dogs received meloxicam (0.2 mg kg-1 IV) at the end of procedure. Heart rate, mean arterial blood pressure, respiratory rate and end-tidal partial pressure of carbon dioxide as well as FE’Iso were recorded and analysed.ResultsA statistical significant difference between groups was detected in FE’Iso, with group M requiring a significantly lower FE’Iso than group P (14.3%) after administration of midazolam. No differences between groups was shown for percentage change in heart rate and mean arterial blood pressure, or end-tidal carbon dioxide and requirement for mechanical ventilation, or rescue analgesia. There was no statistically significant difference in the incidence of complications in group M and P. Group M received significantly more succinylated gelatin solution pre-administration of midazolam than group P, but no differences in fluid administration post-administration of the study treatment (midazolam/placebo) were detected. No statistical significant difference was demonstrated for the use of anticholinergic agents, dobutamine or noradrenaline.ConclusionNo significant effect on cardiovascular parameters could be observed with administration of midazolam, but a modest (14.3%) isoflurane-sparing effect was detected.

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Section: Discussionmentioning

confidence: 99%

Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs

Kropf

Hughes

2018

Ir Vet J

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“…Opioid-free anaesthesia is now more common in human medicine because it has significant implications for clinical care, as opioid dependency is a massive and growing clinical problem in humans. However, in the future this technique will likely benefit distinct subsets of veterinary patients, including canine ovariohysterectomy patients, since the availability of opioids in veterinary medicine is regulated by legal provisions [60].…”

Section: Carprofen Group Meloxicam Group Paracetamol Groupmentioning

confidence: 99%

Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy

Hernández-Ávalos

Valverde

Ibancovichi-Camarillo

et al. 2020

PLoS ONE

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Background In veterinary medicine, the administration of nonsteroidal anti-inflammatory analgesics (NSAIDs) for the control of postsurgical pain in dogs and cats is common given the antiinflammatory, analgesic, and antipyretic effects of these drugs. This study compared the serum biochemical changes and postoperative analgesic effects of paracetamol, meloxicam, and carprofen in bitches submitted to an ovariohysterectomy using the Dynamic Interactive Visual Analog Scale (DIVAS) and Pain Scale of the University of Melbourne (UMPS) scoring systems. Methods Thirty bitches of different breeds underwent elective ovariohysterectomies and were randomly assigned to one of three treatment groups: a paracetamol group [15 mg kg-1 intravenous (IV)], a carprofen group (4 mg kg-1 IV), and a meloxicam group (0.2 mg kg-1 IV). All treatments were administered 30 minutes prior to surgery. Paracetamol was administered every 8 hours postoperatively for 48 hours total, while carprofen and meloxicam were intravenously administered every 24 hours. An evaluation of post-surgical pain was done with the DIVAS and the UMPS. The first post-surgical pain measurement was performed 1 hour

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“…It is not as widely used in veterinary patients as in human medicine, probably because of its toxic effects in cats and scarce reports of its use in dogs. However, paracetamol might be useful in a multimodal analgesic approach (Mburu et al ., 1998; White et al ., 2017). Although other NSAIDs commonly used in dogs such as meloxicam or carprofen could have been used in the present case, the side effects of these drugs, such as the gastrointestinal, renal, or increase in bleeding, were considered (Luna et al ., 2007).…”

Section: Discussionmentioning

confidence: 99%

Anesthetic management of a dog with severe subaortic stenosis and mitral valve disease complicated with atrial fibrillation undergoing ovariohysterectomy

2019

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The anesthetic management in patients with subaortic stenosis and mitral valve disease should involve intensive monitoring and the anesthesiologist’s main concern is to ensure oxygen delivery and tissue perfusion. Since anesthetic procedures in such patients are rare, there is no previous report about the anesthetic management. A 5.5-year old, 32-kg Boxer, suffering a severe heart disease due to a final stage subaortic stenosis and mitral insufficiency, was anesthetized for an ovariohysterectomy to remove an ovarian tumor that was producing high-volume ascites. Methadone (0.3 mg kg −1 ) was administered intramuscularly (IM) for pre-anesthetic medication, etomidate (1.3 mg kg −1 ) and midazolam (0.2 mg kg −1 ) were used for the induction of anesthesia and after endotracheal intubation, anesthesia was maintained with sevoflurane vaporized in oxygen and air. Fentanyl (5–10 μg kg −1 h −1 ) and paracetamol (15 mg kg −1 ) were administered to improve analgesia. Previous persistent atrial fibrillation was refractory to medication (digoxin, diltiazem, and pimobendan) and continued during the anesthetic procedure. Dobutamine (1.5–5 μg kg −1 minute −1 ) helped to maintain mean arterial blood pressure above 60 mmHg. Epidural morphine (0.1 mg kg −1 ) and incisional bupivacaine (2 mg kg −1 ) were administered at the end of surgery to provide postoperative analgesia. Anesthesia was otherwise uneventful, and recovery was considered excellent.

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Opioid-free anaesthesia in three dogs

Cited by 30 publications

References 46 publications

Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs

Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs

Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy

Anesthetic management of a dog with severe subaortic stenosis and mitral valve disease complicated with atrial fibrillation undergoing ovariohysterectomy

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