Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy

Hernández-Ávalos, Ismael; Valverde, Alexander; Ibancovichi-Camarillo, José Antonio; Sánchez-Aparicio, Pedro; Recillas‐Morales, Sergio; Osorio-Ávalos, Jorge; Rodríguez-Velázquez, Desiderio; Miranda-Cortés, Agatha

doi:10.1371/journal.pone.0223697

Cited by 37 publications

(32 citation statements)

References 58 publications

(74 reference statements)

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“…36 Recently, paracetamol at a dose of 10-20 mg/kg every 8 hours has been shown to be safe and provide efficacious postoperative analgesia in dogs. 37,38 Though lower than the United Kingdom licenced dose (33 mg/kg, per os, every 8 hours), 10-15 mg/kg IV or per os has been recommended for the management of canine postoperative pain 39,40 and so 10 mg/kg was administered every 8 hours in this case. Systemic opioid administration is the most common method of providing post-thoracotomy analgesia and forms the mainstay for management of moderate to severe pain.…”

Section: Discussionmentioning

confidence: 89%

Single thoracic epidural injection for intra‐ and post‐lateral thoracotomy analgesia in a dog

Tonge

Robson

Alderson

2021

Vet Record Case Reports

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A 16-month-old cocker spaniel, body mass 15 kg, was presented for general anaesthesia for thoracotomy and lung lobectomy. Preanaesthetic medication was with intramuscular medetomidine (0.01 mg/kg) and methadone (0.2 mg/kg). General anaesthesia was induced with propofol and maintained with propofol and ketamine infusions. A single thoracic epidural injection with levobupivacaine (0.5%, 1 mg/kg) and morphine (0.1 mg/kg) at the 12th-13th thoracic intervertebral space was performed. Postoperative analgesia was with one intravenous dose of methadone (0.2 mg/kg), levobupivacaine (1 mg/kg) via indwelling thoracostomy tube and intravenous paracetamol (10 mg/kg) every 8 hours, and meloxicam (0.1 mg/kg) orally every 24 hours. Pain scoring (Glasgow CMPS-SF) was carried out every 4 hours until 1 hour after removal of the thoracostomy tube, never exceeding 2/24. No further opioid analgesics were administered and the patient was discharged with no complications.

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Section: Discussionmentioning

confidence: 89%

Single thoracic epidural injection for intra‐ and post‐lateral thoracotomy analgesia in a dog

Tonge

Robson

Alderson

2021

Vet Record Case Reports

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“…When administered 30 min prior to ovariohysterectomy incision in dogs, a 15 mg/kg dose of acetaminophen IV administered every 8 h was as effective as 4 mg/kg carprofen IV or 0.2 mg/kg meloxicam IV administered every 24 h for post-operative analgesia for 48 h [ 13 ]. In that study, all dogs also received an intra-operative fentanyl constant rate infusion, and pain assessments were performed using a Dynamic Interactive Visual Analog Scale (DIVAS) and Pain Scale of the University of Melbourne (UMPS) scoring systems.…”

Section: Discussionmentioning

confidence: 99%

“…Comparatively, the use of intravenous acetaminophen in animals is limited. Its use has been reported in dogs [ 13 ] and in horses [ 14 ] with variable analgesic efficacy.…”

Section: Introductionmentioning

confidence: 99%

Intravenous Acetaminophen Does Not Provide Adequate Postoperative Analgesia in Dogs Following Ovariohysterectomy

Leung

Beths

Carter

et al. 2021

Animals

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(1) Objective: To investigate the analgesic effects of intravenous acetaminophen after intravenous administration in dogs presenting for ovariohysterectomy. (2) Methods: 14 ASA I client-owned female entire dogs. In this randomized, blinded, clinical study, dogs were given meperidine and acepromazine intramuscularly before induction of anesthesia with intravenous propofol. Anesthesia was maintained with isoflurane in oxygen. Intravenous acetaminophen 20 mg/kg or 0.9% NaCl was administered postoperatively. Pain assessments were conducted using the Glasgow Pain Scale short form before premedication and at 10, 20, 60, 120, and 180 min post-extubation or until rescue analgesia was given. The pain scores, times, and incidences of rescue analgesia between the groups was compared. Blood was collected before and 2, 5, 10, 20, 40, and 80 min after acetaminophen administration. Acetaminophen plasma concentration was quantified by liquid chromatography-mass spectrometry. The acetaminophen plasma concentration at the time of each pain score evaluation was subsequently calculated. (3) Results: There was no significant difference in pain scores at 10 min, highest pain scores, or time of rescue analgesia between groups. In each group, 3 dogs (43%) received rescue analgesia within 20 min. (4) Conclusions: Following ovariohysterectomy in dogs, there was no detectable analgesic effect of a 20 mg/kg dosage of intravenous acetaminophen administered at the end of surgery.

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“…72 While the dose of paracetamol we administered was below the licensed dose in dogs (33 mg/kg every 8 hours; Pardale-V), it was similar to the one that provided postoperative analgesia in dogs undergoing ovariohysterectomy. 9 Nevertheless, the relationship between dose and analgesic efficacy of paracetamol needs to be better established in dogs.…”

Section: Discussionmentioning

confidence: 99%

Perioperative use of thoracic epidural anaesthesia, dexmedetomidine and magnesium sulphate infusion in a dog undergoing neuroendocrine tumour resection

Viilmann¹,

Vettorato²

2021

Vet Record Case Reports

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An 11-year-old, 22 kg, male neutered English Staffordshire Bull Terrier, in which a pheochromocytoma was removed from the left retroperitoneal space, was referred to investigate the regrowth of a mass in the same region. A neuroendocrine tumour, compatible with pheochromocytoma, was cytologically diagnosed after ultrasound-guided fine-needle aspirates, and the dog underwent explorative celiotomy. A combination of thoracic epidural anaesthesia, dexmedetomidine and magnesium sulphate infusion was used intraoperatively to control nociception and potential haemodynamic changes caused by sudden catecholamines release. Postoperative analgesia was provided by administering 0.12% levobupivacaine through the thoracic epidural catheter and oral paracetamol and gabapentin. Postoperative methadone was administered twice during the first 24 postoperative hours only. Two days after the surgery, the dog was anaemic and packed red blood cells were administered. No other complications occurred, and the dog was discharged from the hospital 5 days following surgery. INVESTIGATIONSAbnormalities found on blood analysis are reported in Table 1. Prothrombin time was 6.0 seconds [reference interval (r.i.), 7.0-12.0], activated partial thromboplastin time was 16.0 seconds (r.i., 15.0-25.0). The blood type was dog erythrocyte antigen (DEA) 1.1-negative. In addition to CT findings, an abdominal ultrasound (US) showed nodular hepatopathy, bilateral chronic nephropathy, left mild hydronephrosis. The mass was

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Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy

Cited by 37 publications

References 58 publications

Single thoracic epidural injection for intra‐ and post‐lateral thoracotomy analgesia in a dog

Single thoracic epidural injection for intra‐ and post‐lateral thoracotomy analgesia in a dog

Intravenous Acetaminophen Does Not Provide Adequate Postoperative Analgesia in Dogs Following Ovariohysterectomy

Perioperative use of thoracic epidural anaesthesia, dexmedetomidine and magnesium sulphate infusion in a dog undergoing neuroendocrine tumour resection

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