Opioid abuse and cognitive performance

Mintzer, Miriam Z.; Copersino, Marc L.; Stitzer, Maxine L.

doi:10.1016/j.drugalcdep.2004.10.008

Cited by 140 publications

(114 citation statements)

References 22 publications

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“…To date, only a handful of studies have investigated cognitive performance in opiate abstinent former heroin abusers (Verdejo et al, 2005;Lee and Pau, 2002;Pau et al, 2002;Davis et al, 2002;Mintzer et al, 2005). Three of the studies concluded that opiate-abstinent subjects demonstrate a lesser degree of neuropsychological impairment compared to subjects receiving methadone maintenance therapy (MMT) (Verdejo, 2005;Davis et al, 2002;Mintzer et al, 2002Mintzer et al, ,2005.…”

Section: Introductionmentioning

confidence: 99%

“…Three of the studies concluded that opiate-abstinent subjects demonstrate a lesser degree of neuropsychological impairment compared to subjects receiving methadone maintenance therapy (MMT) (Verdejo, 2005;Davis et al, 2002;Mintzer et al, 2002Mintzer et al, ,2005. Verdejo et al (2005) reported that methadone maintained subjects performed worse than abstinent heroin abusers on tests of processing speed and response inhibition (Five Digit Test), tests of visuo-spatial attention and cognitive flexibility (Oral Trails Test), and a test of reasoning (Wechsler Adult Intelligence Scale-III Similarities subtest).…”

Section: Introductionmentioning

confidence: 99%

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Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment

Prosser

Cohen

Steinfeld

et al. 2006

Drug and Alcohol Dependence

126

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Objective-An accumulating body of research suggests that former heroin abusers in methadone maintenance therapy (MMT) exhibit deficits in cognitive function. Whether these deficits are present in former methadone maintained patients following discontinuation of MMT is unknown. This study tests the hypothesis that former heroin users who have detoxified from methadone maintenance therapy and are drug-free have less pronounced cognitive impairment than patients continuing longterm MMT.Method-A series of neuropsychological tests were administered to three groups of subjects: 29 former heroin addicts receiving methadone maintenance treatment, 27 former heroin addicts withdrawn from all opiates, and 29 healthy controls without a history of drug dependence. Testing included Wechsler Adult Intelligence Scale-Revised Vocabulary Test, the Stroop Color-Word Test, the Controlled Oral Word Association Test, the Benton Visual Retention Test, and a Substance Use Inventory.Findings-Both methadone-maintained and abstinent subject groups performed worse than controls on tasks that measured verbal function, visual-spatial analysis and memory, and resistance to distractibility. Abstinent subjects performed worse than their methadone maintained counterparts on tests measuring visual memory and construct formation. Cognitive impairment did not correlate with any index of drug use.Conclusions-We confirmed previous findings of neuropsychological impairment in long-term MMT recipients. Both patients receiving MMT and former heroin users in prolonged abstinence exhibited a similar degree of cognitive impairment. Cognitive dysfunction in patients receiving methadone maintenance may not resolve following methadone detoxification.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment

Prosser

Cohen

Steinfeld

et al. 2006

Drug and Alcohol Dependence

126

View full text Add to dashboard Cite

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“…Thesedysfunctions have been proven in subjects going through different abstinence phases (Rose et al, 1996;Mintzer and Stitzer, 2002;Mintzer et al, 2005;Prosser et al, 2009). Furthermore, the disruption of dopamine neurons in the striatum of former heroin-addicts under methadone maintenance treatment, has been shown (Shi et al, 2008).…”

Section: Limitations Of Existing Resting-state Literaturementioning

confidence: 96%

“…Many studies have been performed on users being short-term abstinent (Lee and Pau, 2002;Mintzer et al, 2005;Fishbein et al, 2007;Verdejo-García et al, 2007b;Wang et al, 2010;Jiang et al, 2011Jiang et al, , 2013Li et al, 2013bLi et al, , 2013c)whereas in others active drug users were recruited (Liu et al, 2008(Liu et al, , 2009aQiu et al, 2013;Wang et al, 2013;Zhang et al, 2013). Moreover, other researchers have studied either mixed cohorts (Bora et al, 2010), including participants in different abstinence phases (Ma et al, , 2011 or prolonged-abstinent individuals (Liu et al, 2009b;Wang et al, 2011;Lin et al, 2012;Moreno-López et al, 2012;Zeng et al, 2013).…”

Section: Limitations Of Existing Resting-state Literaturementioning

confidence: 99%

Resting-state Abnormalities in Heroin-dependent Individuals

Pandria

Kovatsi

Vivas³

et al. 2018

Neuroscience

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Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. AbstractDrug addiction is a major health problem worldwide. Recent neuroimaging studies have shed light into the underlying mechanisms of drug addiction as well as its consequences to the human brain. The most vulnerable, to heroin addiction, brain regions have been reported to be specific regions in the prefrontal, parietal, occipital, and temporal lobes, as well as, some subcortical regions.The brain regions involvedare linked with reward, motivation/drive, memory/learning, inhibition as well as emotional control andseem to form circuitsthat interact with each other. So, along with neuroimaging studies, recent advances in resting-state dynamics might allow further assessments upon the multilayer complexity of addiction. In the current manuscript, we comprehensively reviewand discuss all the existing resting-state neuroimaging findings classified into three overlapping and interconnected groups: functional connectivity alterations, structural deficits and abnormal topological properties. Moreover, behavioral traits of heroin-addicted individuals as well as the limitations of the currently available studies are also reviewed. Finally, in need of a contemporary therapya multimodal therapeutic approach is suggested using classical treatment practices along with current neurotechonologies, such as neurofeedback and goal-oriented video-games Keywords:Heroin addiction, resting-state, functional and structural connectivity, small-world properties, behavioral traits of heroin-dependent individuals. Radial Diffusivity (RD) 5 Drug addiction or substance dependence (Koob and Le Moal, 2005)is defined as a multifaceted neuropsychiatric disorder resulting from complex interactions between neurobiological, environmental, genetic and pharmacological variables (Sutherland et al., 2012).It affects both cognitive as well as emotional processes . Furthermore, the compulsive seeking and taking of the drug despite the negative consequences, (including downward social mobility (Denier et al., 2013b)), constitutes its behavioral phenotype (Volkow ...

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“…Es necesario tener en cuenta que, como sucede con el resto de opiáceos (Katz, 2005;Benyamin et al, 2008), la metadona no es un fármaco exento de efectos secundarios e indeseados (Bell y Zador, 2000;Bileviciute-Ljungar, Häglund, Carlsson y von Heijne, 2014;Chugh et al, 2008;Grönbladh y Öhlund, 2011;Webster, 2013), cuya probabilidad de aparición e intensidad se incrementan en paralelo a las dosis (Leavitt, 2003;Walker, Klein y Kasza, 2003), apareciendo con cierta frecuencia complicaciones de gran envergadura a dosis altas (Krantz, Kutinsky, Robertson y Mehler, 2003), aunque también a dosis no tan altas (Krantz, Martin, Stimmel, Mehta y Haigney, 2009;Roy et al, 2012). Entre estos efectos secundarios, los déficits en el rendimiento neuropsicológico están entre los más frecuentemente identificados (Bracken et al, 2012;Gruber et al, 2006;Loeber, Kniest, Diehl, Mann y Croissant, 2008;Mintzer, Copersino y Stitzer, 2005;Mintzer y Stitzer, 2002;Rass et al, 2014) y se incrementan en paralelo a las dosis (Rass et al, 2014). Los pacientes en tratamiento con metadona presentaron déficits cognitivos significativos, mientras que quienes estaban en abstinencia prolongada de opiáceos y sin tratamiento rendían significativamente mejor (Verdejo, Toribio, Orozco, Puente y Pérez-García, 2005), incluso como los controles (Darke, McDonald, Kaye y Torok, 2012).…”

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Dosis de metadona y su relación con calidad de vida, satisfacción, psicopatología, rendimiento cognitivo y consumo adicional de sustancias no prescritas

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MethaQoL

2016

Adicciones

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The effectiveness of methadone maintenance treatment is beyond any doubt, but there remains some incertitude about the appropriate and effective dosage and the objectives that should be achieved by this therapy. Some authors maintain that only doses higher than 50-60 mg/day ought to be considered effective, since only these block all the opioid receptors. But others propose the use of doses adjusted to the needs of the patient, based on their recovery process. ADICCIONES, 2017 · VOL. 29 NÚM. 1 38 Dosis de metadona y su relación con calidad de vida, satisfacción, psicopatología, rendimiento cognitivo y consumo adicional de sustancias no prescritas

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Opioid abuse and cognitive performance

Cited by 140 publications

References 22 publications

Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment

Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment

Resting-state Abnormalities in Heroin-dependent Individuals

Dosis de metadona y su relación con calidad de vida, satisfacción, psicopatología, rendimiento cognitivo y consumo adicional de sustancias no prescritas

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