Opinions on the Nature of B-1 Cells and Their Relationship to B Cell Neoplasia

Potter, Michael; Melchers, Fritz

doi:10.1007/978-3-642-57284-5_32

Cited by 9 publications

(10 citation statements)

References 80 publications

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“…Normal CD5+ B cells are thought to remain in circulation and may be involved in the production of low-affinity autoreactive antibodies. 3,4 While CLL/SLL may represent a bona fide CD5+ B-cell lymphoproliferative disorder, the relationship of MCL to normal CD5+ B cells is not entirely understood.…”

mentioning

confidence: 99%

B-Cell Lymphomas With Coexpression of CD5 and CD10

Dong¹,

Gorczyca²,

Liu³

et al. 2003

Am J Clin Pathol

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Coexpression of CD5 and CD10 is highly unusual in B-cell lymphomas and may pose a diagnostic challenge. We report 42 cases of B-cell lymphoma with simultaneous expression of CD5 and CD10. They made up approximately 0.4% of all B-cell lymphomas seen during the study period and included the following cases: large B-cell lymphoma (LBCL), 14 (33%); follicular lymphoma (FL), 10 (24%); mantle cell lymphoma (MCL), 9 (21%); chronic lymphocytic leukemia, 4 (10%); acute precursor B-cell lymphoblastic leukemia/lymphoma, 2 (5%); and other low-grade B-cell lymphomas, 3 (7%). All MCLs had overexpression of bcl-1 or the t(11;14) and were CD43+. All FLs had typical histomorphologic features and were bcl-2+ and bcl-6+ but CD43-. Of 14 LBCLs, 5 were histologically high-grade. Six (43%) of 14 patients with LBCL died within 10 months of diagnosis of CD5+CD10+ lymphoma (median survival, 4 months), including all 3 patients with stage IV disease and 2 of 5 with histologically high-grade lymphoma. Our findings indicate that coexpression of CD5 and CD10 is rare but occurs in diverse subtypes of B-cell lymphoma. Investigation of bcl-1, bcl-6, and CD43 and morphologic evaluation may resolve the potential confusion in diagnosis and lead to the recognition of the correct lymphoma subtype.

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mentioning

confidence: 99%

B-Cell Lymphomas With Coexpression of CD5 and CD10

Dong¹,

Gorczyca²,

Liu³

et al. 2003

Am J Clin Pathol

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“…CLL. This view is based on a number of different observations that suggest B1 cells manifest an intrinsic predisposition for abnormal growth and that this feature combined with the chronic stimulation with self-Ag makes them likely candidates for uncontrolled proliferation [41]. The finding that 8 of 31 examined FL expressed Ig with autoantibody activity speaks in the favor of the chronic stimulation by self-Ag as a factor in tumorigenesis of some lymphomas [42].…”

Section: Bcr Signals Positive Selection and Persistancementioning

confidence: 98%

Malignant B Cells and Antigenic Receptor: Necessity or Habit?

Ćirić

Pease

2002

Leukemia & Lymphoma

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B-cell malignancies account for the majority of lymphoid tissue neoplasia. Similar to normal B cells, malignant B cells in most Hodgkin's and non-Hodgkin's types of lymphomas express B-cell receptor (BCR) on their membrane. Since neoplastic B cells retain the capacity to respond to microenvironmental signals, and in many respects still behave as normal B cells, it does not seem bizarre that the BCR, which dominates the biology of normal B cells, can remain equally important for some malignant B cells. Indirect evidence suggests that retained BCR expression, and in certain cases coupled with stimulation by antigen (Ag), may be necessary for the viability of some B-cell tumors. The aim of this review is to consider the evidence regarding the role of the BCR in tumorigenesis of B-cell lymphomas, and discuss different approaches used in evaluating this role in the persistence and progression of these malignancies. The diversity in B-cell lymphomas prevents easy classification of these cancers based on their dependence on BCR expression. It seems likely that some malignant B cells need BCR expression, or additionally, stimulation by Ag in order to survive. However, through accumulation of additional genetic changes, the original tumor can give rise to a clone that no longer requires signals from the BCR to survive. Thus, most B-cell lymphomas may initially retain dependence on BCR expression that governs normal B-cell physiology and may lose it only at later stages of tumor progression, through the accumulation of additional transforming events.

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“…Although production of the basal set of "natural antibodies" is maintained throughout life, it is likely that some new B-1 cell clones might be generated continuously from precursors in the bone marrow as a minor divergent pathway, or from the B-2 cells (Haughton et al 1993;Hayakawa et al 2003). At present, a heterogeneous property of the B-1 cell compartment with double origin has been suggested, depending upon the quality of interaction with antigens and with other cells engaged in the immune response (Potter and Melchers 2000).…”

Section: Introductionmentioning

confidence: 97%

Haemopoietic progenitors in the adult mouse omentum: permanent production of B lymphocytes and monocytes

et al. 2004

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The coelome-associated lympho-myeloid tissues, including the omentum, are derived from early embryo haemopoietic tissue of the splanchnopleura, and produce B lymphocytes and macrophages. They are reactive in pathologies involving coelomic cavities, in which they can expand in situ the cells of inflammatory infiltrates. We have addressed the question of the role of the adult omentum in permanent basal production of early lymphopoietic progenitors (pro-B/pre-B cells), through characterisation of omentum cells ex vivo, and study of their in vitro differentiation. We have shown that the murine omentum produces early haemopoietic progenitors throughout life, including B-cell progenitors prior to the Ig gene recombination expressing RAG-1 and lambda5, as well as macrophages. Their production is stroma-dependent. The omentum stroma can supply in vitro the cytokines (SDF-1alpha, Flt3 ligand and IL-7) and the molecular environment required for generation of these two cell lineages. Omentum haemopoietic progenitors are similar to those observed in foetal blood cell production, rather than to progenitors found in the adult haemopoietic tissue in the bone marrow--in terms of phenotype expression and differentiation capacity. We conclude that a primitive pattern of haemopoiesis observed in the early embryo is permanently preserved and functional in the adult omentum, providing production of cells engaged in nonspecific protection of abdominal intestinal tissue and of the coelomic cavity.

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Opinions on the Nature of B-1 Cells and Their Relationship to B Cell Neoplasia

Cited by 9 publications

References 80 publications

B-Cell Lymphomas With Coexpression of CD5 and CD10

B-Cell Lymphomas With Coexpression of CD5 and CD10

Malignant B Cells and Antigenic Receptor: Necessity or Habit?

Haemopoietic progenitors in the adult mouse omentum: permanent production of B lymphocytes and monocytes

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