B-Cell Lymphomas With Coexpression of CD5 and CD10

Abstract

Coexpression of CD5 and CD10 is highly unusual in B-cell lymphomas and may pose a diagnostic challenge. We report 42 cases of B-cell lymphoma with simultaneous expression of CD5 and CD10. They made up approximately 0.4% of all B-cell lymphomas seen during the study period and included the following cases: large B-cell lymphoma (LBCL), 14 (33%); follicular lymphoma (FL), 10 (24%); mantle cell lymphoma (MCL), 9 (21%); chronic lymphocytic leukemia, 4 (10%); acute precursor B-cell lymphoblastic leukemia/lymphoma, 2 (5%); and other low-grade B-cell lymphomas, 3 (7%). All MCLs had overexpression of bcl-1 or the t(11;14) and were CD43+. All FLs had typical histomorphologic features and were bcl-2+ and bcl-6+ but CD43-. Of 14 LBCLs, 5 were histologically high-grade. Six (43%) of 14 patients with LBCL died within 10 months of diagnosis of CD5+CD10+ lymphoma (median survival, 4 months), including all 3 patients with stage IV disease and 2 of 5 with histologically high-grade lymphoma. Our findings indicate that coexpression of CD5 and CD10 is rare but occurs in diverse subtypes of B-cell lymphoma. Investigation of bcl-1, bcl-6, and CD43 and morphologic evaluation may resolve the potential confusion in diagnosis and lead to the recognition of the correct lymphoma subtype.

Tissue flow cytometry immunophenotyping in the diagnosis and classification of non‐Hodgkin's lymphomas: A retrospective evaluation of 1,792 cases

“…The surface or cytoplasmic light-chain evaluation was the most useful parameter in identifying a B-cell lymphoma, whereas CD5 and CD10 are useful in identifying the different subtypes (1). However, their specificity is not absolute on neoplastic cells, as stands out from data also reported by us in Table 4; in fact they may be absent in FL (CD10 À FL) (37) or can be unexpectedly expressed elsewhere, such as CD5 on some SMZL cases (5,49) and FL (36,39,50,51), CD10 on SLL (50,51), NMZL (43), MCL and MALT (37), and HCL (52), CD5/ CD10 coexpression on DLBCL (35,50,53). These kinds of B-NHL still remain challenging for flow cytometrists, because the lack of a specific phenotype and their great heterogeneity, especially observed among MZL (nodal, splenic, extranodal), SL and LPL, determine their identification mainly on the j/k ratio.…”

A Case Presenting with Splenic Infarct Diagnosed as Primary Bone Marrow CD5 Positive DLBCL: A Clinicopathological Correlation

“…The main differentials include CLL in Richter's transformation to DLBCL, mantle cell lymphoma (MCL), secondary CD5? DLBCL (Non-Richter's), intravascular B cell lymphoma and primary CNS lymphoma [6].…”

Sequence analysis proves clonal identity in five patients with typical and blastoid mantle cell lymphoma

“…23 Reports of aberrant CD10 expression by MCL are also rare, and most often associated with blastoid morphology. 23,24 In patient 2, both the typical and blastoid MCL involved the ileum at diagnosis of blastoid MCL. Three identical clones were identified in each component.…”