Ophthalmic Manifestations of Leukemia

Schachat, Andrew P.

doi:10.1001/archopht.1989.01070010715033

Cited by 190 publications

(108 citation statements)

References 23 publications

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“…1 Of all leukaemia patients, about 5% have been reported to develop visual loss attributable to the underlying condition. 2 Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in Western countries. 1 Ocular involvement in CLL can either be direct via leukaemic infiltrate 3 or indirect as a consequence of compromised immune function, hyperviscosity, thrombocytopaenia, anaemia, or indeed the treatment of CLL.…”

Section: Introductionmentioning

confidence: 44%

The prevalence of ocular disease in chronic lymphocytic leukaemia

McKibbin

Burton

2003

Eye

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Aim Previous surveys of ocular disease in leukaemia patients have shown the retina, choroid, and orbit as the most commonly involved sites. Depending on the type of leukaemia and the study design, the prevalence of ocular disease in leukaemia varies from 30 to 90%. Although chronic lymphocytic leukaemia (CLL) is the most common leukaemia in Western countries, the prevalence of ocular disease in CLL is not known. The aim of this prospective study was to estimate the prevalence of ocular disease in CLL. Patients and Methods All CLL patients attending either a teaching or district general hospital haematology clinic were invited to undergo a full eye examination. The clinical stage of the CLL (Binet) at the time of the eye examination and the most recent full blood count (FBC) indices were recorded for each patient. Results Over 6 months, 25 patients with an average age of 65 were recruited. A total of 18 patients had Binet stage A disease, three had stage B, and four stage C. The mean FBC indices at the time of examination were haemoglobin 13.5 g/dl, white cell count 37.4 Â 10 9

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Section: Introductionmentioning

confidence: 44%

The prevalence of ocular disease in chronic lymphocytic leukaemia

McKibbin

Burton

2003

Eye

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“…From an aetiopathogenetic standpoint, ocular involvement can be direct as a result of leukaemic infiltration or indirect due to effects of anaemia, thrombocytopenia, hyperviscosity, immunosuppression or infections. 4 Previous studies have described an overall ocular involvement in 9-90% of cases with leukaemias based on clinical examination 4 or autopsy findings. 5,6 A figure of about 40% based on prospective clinical studies is more realistic.…”

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confidence: 99%

“…5,6 A figure of about 40% based on prospective clinical studies is more realistic. 4,7 However, previously published reports have been biased towards acute leukaemia, with CLL representing less than 1% of all cases in one large series. 4 None of the studies have specifically reported ocular involvement in CLL.…”

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confidence: 99%

“…4,7 However, previously published reports have been biased towards acute leukaemia, with CLL representing less than 1% of all cases in one large series. 4 None of the studies have specifically reported ocular involvement in CLL. The question is pertinent for several reasons: CLL is the most common form of leukaemia; the incidence is rising with increased life span; many patients have mild disease and are expected to have a normal life span; and the therapeutic modalities used to treat CLL are known to cause ocular complications.…”

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confidence: 99%

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The prevalence of ocular disease in chronic lymphocytic leukaemia

Singh

2003

Eye

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“…[5][6][7] The retina is most commonly affected, either as a result of direct infiltration or secondary to changes in blood viscosity and clotting status. 7 Cutaneous lesions have also been well described. 6,8,9 Involvement of the periorbital skin however is rare.…”

Section: Commentmentioning

confidence: 46%