The prevalence of ocular disease in chronic lymphocytic leukaemia

Singh, Anant Kumar

doi:10.1038/sj.eye.6700278

Cited by 13 publications

(9 citation statements)

References 7 publications

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“…Consistent with a previous report,14 and in keeping with the natural prevalence pattern of leukemia,1 more cases of chronic than acute leukemia were seen in our study. Additionally, acute leukemia often run a rapidly fatal course compared with chronic leukemia which is further aggravated in the resource-deficient African setting by pre-presentation care-pathway delays with attendant adverse implications for prognosis 1415.…”

Section: Discussionsupporting

confidence: 93%

Ophthalmic manifestations of leukemia in a tertiary hospital population of adult Nigerian Africans

Eze

Ibegbulam

Ocheni

2010

Middle East Afr J Ophthalmol

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Purpose:To determine the prevalence and pattern of leukemic ophthalmopathy among adults at the University of Nigeria Teaching Hospital (UNTH), Enugu, south-eastern, Nigeria.Materials and Methods:This prospective, observational case series surveyed adult leukemia patients presenting at UNTH’s departments of Hematology/Immunology and Ophthalmology from July 2003 to August 2008. The demographic profile, clinical data from for each individual in the cohort were statistically collated and analyzed. A P <0.05 was considered as statistically significant.Results:There were 72 participants (45 males and 27 females), aged 32.7 ± 9.8 years (range, 18 years to 72 years). Leukemic ophthalmopathy was present in 77.8% of subjects. The leading ophthalmic manifestations of leukemia were retinal vascular abnormalities in 50.0% of subjects, conjunctival pallor in 27.8% of subjects, sub-conjunctival hemorrhage in 19.4% of subjects, and retinal hemorrhage in 16.7% of subjects. Ocular co-morbidity was present in 47.2% of subjects. Vision loss occurred in 37.5% of subjects, of which 32.1% was leukemia related, and the remaining due to ocular co-morbidity. Leukemic ophthalmopathy was more prevalent in chronic leukemia (P <0.05), frequently affected the ocular posterior segment (P < 0.05), and often resulted from secondary hematologic complications (P <0.05). There was no gender difference in the prevalence of leukemia (P = 0.0822) or leukemic ophthalmopathy (P = 0.6624).Conclusion:The prevalence of leukemic ophthalmopathy in Enugu is high. It is often associated with significant ocular co-morbidity and vision loss. These have implications for clinicians involved in leukemia management. Early diagnosis and regular ophthalmic examinations are recommended to optimize treatment outcomes.

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Section: Discussionsupporting

confidence: 93%

Ophthalmic manifestations of leukemia in a tertiary hospital population of adult Nigerian Africans

Eze

Ibegbulam

Ocheni

2010

Middle East Afr J Ophthalmol

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“…Ophthalmic involvement in leukaemia can precede the diagnosis of leukaemia or can occur during course of the disease or secondary to treatment. 7 The reported prevalence of ocular involvement in leukaemia ranges from 9% to as high as 90%. 8,9 This divergent variation in results may imply the transient nature of leukemic ocular findings, which may be waxing and waning with time and treatment.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic Manifestations In Patients of Acute Leukaemia Presenting to A Tertiary Care Centre In Western Rajasthan

Kochar¹

2018

DJO

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“…[ 2 3 ] Ocular involvement in leukemia can precede the diagnosis of leukemia or can occur during the course of the disease. [ 4 ]…”

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confidence: 99%

Ophthalmic manifestations of acute and chronic leukemias presenting to a tertiary care center in India

Koshy

John

Thomas

et al. 2015

Indian J Ophthalmol

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Context:Screening for ocular manifestations of leukemia, although not a routine practice, is important as they may antedate systemic disease or form an isolated focus of its relapse.Aims:This study evaluates the spectrum of ocular manifestations in acute and chronic leukemias presenting to a tertiary care center in India.Settings and Design:Subjects of leukemia presenting to a tertiary care center in India.Subjects and Methods:A prospective, cross-sectional study looking at the spectrum of ocular manifestations in all inpatients of acute or chronic leukemia.Statistical Analysis Used:The collected data were analyzed using the Statistical Package for Social Sciences for Windows software, version 16 (SPSS Inc., Chicago, Illinois, USA).Results:The study subjects (n = 96) comprised 61 males and 35 females whose age ranged from 18 months to 91 years (mean = 39.73, ±22.1). There were 79 adults and 17 children, 53 new and 43 existing patients, 68 acute and 28 chronic, 61 myeloid and 35 lymphoid patients. Ocular lesions were found in 42 patients (43.8%). The ocular manifestations of leukemia were significantly (P = 0.01467) more frequent in acute 35/68 (51.9%) than chronic 7/28 (25%) leukemias. Primary or direct leukemic infiltration was seen in 8 (8.3%) subjects while secondary or indirect involvement due to anemia, thrombocytopenia, hyperviscosity, total body irradiation, and immunosuppression were seen in 42 (43.8%) subjects. Ocular changes were present in 37/79 (46.8%) adults and 5/17 (29.4%) children (P = 0.09460). Twenty-eight males (28/61) 45.9% and 14/35 (40%) females had ocular manifestations (P = 0.2874). The ocular manifestations were significantly (P = 0.01158) more frequent in myeloid leukemias 32/61 (52.9%) than lymphoid leukemias 10/35 (28.6%).Conclusions:Leukemic ophthalmic lesions were found in 42/96 (43.8%) patients. Ocular involvement is more often seen in adults, acute and myeloid leukemias. All the primary leukemic manifestations were seen in males. A periodic ophthalmic examination should be mandatory for all leukemic patients, as ocular changes are often picked up in asymptomatic patients.

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The prevalence of ocular disease in chronic lymphocytic leukaemia

Cited by 13 publications

References 7 publications

Ophthalmic manifestations of leukemia in a tertiary hospital population of adult Nigerian Africans

Ophthalmic manifestations of leukemia in a tertiary hospital population of adult Nigerian Africans

Ophthalmic Manifestations In Patients of Acute Leukaemia Presenting to A Tertiary Care Centre In Western Rajasthan

Ophthalmic manifestations of acute and chronic leukemias presenting to a tertiary care center in India

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