Ophthalmic manifestations of dermatomyositis

Backhouse, O; Griffiths, Bridget; Henderson, Timothy; Emery, Paul

doi:10.1136/ard.57.8.447

Cited by 40 publications

(22 citation statements)

References 16 publications

(7 reference statements)

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“…The pathogenesis of orbital myositis remains elusive. Retinopathy associated with dermatomyositis is rare, and retinopathy completely resolves without lasting complications 6 . However, profound visual decrease was found in our patient when hydroxychloroquine was withdrawn.…”

mentioning

confidence: 48%

Acute-onset adult dermatomyositis presenting with erythroderma and diplopia

Liu

Wang

2007

Clin Exp Dermatol

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confidence: 48%

Acute-onset adult dermatomyositis presenting with erythroderma and diplopia

Liu

Wang

2007

Clin Exp Dermatol

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“…Ophthalmic complications are infrequent in patients with dermatomyositis and include periorbital edema and redness causing chemosis (heliotrope rash), ptosis and exophthalmos, pain and ophthalmoplegia, conjunctival pseudopolyposis, conjunctivitis, iritis, episcleritis, uveitis, glaucoma, cotton wool spots, optic atrophy and lens abnormalities . Visual disturbances in dermatomyositis are rare and have been attributed to intraretinal hemorrhages and macular exudates .…”

Section: Discussionmentioning

confidence: 99%

Atypical central retinal artery occlusion: an uncommon cause of retinopathy and visual loss in dermatomyositis

Sharma¹,

Prashar²,

Tuli³

et al. 2015

Int J of Rheum Dis

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Several ophthalmic manifestations in patients with dermatomyositis have been described but involvement of the retina is rare. A 39-year-old man diagnosed with dermatomysitis had developed sudden painless visual loss in the left eye. He was non-diabetic and non-hypertensive. He was on treatment with systemic prednisolone (50 mg/day) and methotrexate (7.5 mg/day) for dermatomyositis. His visual acuity was finger counting at 2 feet in the left eye and 6/6 in the right eye. Left fundus showed slight blurring of the optic disc margins, large peripapillary flame-shaped haemorrhages and extensive area of opacification suggestive of central retinal artery occlusion (CRAO) with sparing of the area supplied by the cilioretinal artery. The exact pathomechanism of CRAO in dermatomyositis remains poorly elucidated. The infarctive events following endothelial damage and platelet thrombi occurring in arterioles and capillaries of retina, optic disc and choriocapillaries causing ischemia/infarction have been suggested as possible reasons. However, central artery occlusion from high intraocular pressure from marked (heliotrope) orbital edema appears more plausible in our case. The degree of retinal damage is variable when CRAO lasts between 105 and 240 min and irreversible profound visual loss may occur from its occlusion lasting for more than 240 min. A prompt ophthalmological opinion/management is recommended to limit its progression.

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“…A retinopatia é rara e pode ser vista na DMJ. 5,39,42 Os pacientes com DM apresentam algumas condições que os predispõem a maior risco de infecções e incluem envolvimento esofágico, miosite de musculatura torácica, calcinose cutânea e uso de agentes imunossupressores, resultando em grande porcentagem de óbitos. 43 A avaliação de exames subsidiários dos pacientes com DM referente aos vários sistemas deve ser direcionada por seus sintomas.…”

Section: Manifestações Clínicasunclassified

Dermatomiosite

Ortigosa

Reis

2008

An. Bras. Dermatol.

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Resumo: Dermatomiosite é doença idiopática inflamatória crônica que afeta a musculatura estriada, a pele e outros órgãos. Apresenta critérios diagnósticos definidos por Bohan & Peter, podendo os pacientes ser classificados em cinco grupos: dermatomiosite juvenil, dermatomiosite primária idiopá-tica, dermatomiosites amiopáticas, dermatomiosite associada a neoplasias e dermatomiosite associada a outras doenças do tecido conectivo. O sexo feminino é mais afetado, e a idade média do diagnósti-co é 40 anos. Manifestações cutâneas são observadas em todos os pacientes. Das alterações sistêmicas, a manifestação muscular mais freqüente é a perda de força proximal, e a manifestação pulmonar mais comum é a pneumopatia intersticial. Podem ser observadas neoplasias durante o seguimento da doença, sendo mais freqüentes nos pacientes acima de 60 anos. A desidrogenase lática é a enzima muscular alterada na maioria dos casos. Para diagnóstico da dermatomiosite, pode ser realizado exame anatomopatológico de biópsia cutânea e biópsia muscular, além de eletroneuromiografia. Os corticóides são a terapia mais utilizada. As causas de óbito mais freqüentes são a neoplasia maligna, a septicemia e a infecção pulmonar.

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Ophthalmic manifestations of dermatomyositis

Cited by 40 publications

References 16 publications

Acute-onset adult dermatomyositis presenting with erythroderma and diplopia

Acute-onset adult dermatomyositis presenting with erythroderma and diplopia

Atypical central retinal artery occlusion: an uncommon cause of retinopathy and visual loss in dermatomyositis

Dermatomiosite

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