Ophthalmic Manifestations in 18 Patients with Botulism Diagnosed in Porto, Portugal Between 1998 and 2003

Penas, Susana; Faria, Olinda; Serrão, Rosário; Capão-Filipe, J.A.; Mota-Miranda, António; Falcão‐Reis, Fernando

doi:10.1097/01.wno.0000189828.46763.08

Cited by 19 publications

(11 citation statements)

References 9 publications

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“…Only 2 of 18 (11%) showed ocular signs initially. [7] Of ocular findings, blurred vision is the most common (89–100%) followed by ptosis (80%). [37] Observed extraocular muscle dysfunction is rare and when described is bilateral.…”

Section: Discussionmentioning

confidence: 99%

“…[7] Of ocular findings, blurred vision is the most common (89–100%) followed by ptosis (80%). [37] Observed extraocular muscle dysfunction is rare and when described is bilateral. [3] Our patient presented with diplopia and was found to have esodeviation at distance fixation worse in right gaze progressing to an ipsilateral right lateral rectus paresis.…”

Section: Discussionmentioning

confidence: 99%

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Diplopia as the primary presentation of foodborne botulism

Khakshoor¹,

Moghaddam²,

Vejdani³

et al. 2012

Oman J Ophthalmol

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Foodborne botulism is a serious condition caused by Clostridium botulinum neurotoxin. Clinically, botulism presents as bilateral cranial nerve neuropathy and descending paralysis. We report a unique presentation of botulism to remind clinicians of this potentially fatal condition. In this observational case report initial evaluation showed only esodeviation. This progressed to unilateral cranial nerve six (CN VI) paresis along with systemic signs. Clinical diagnosis was made based on in-depth history and concurrent symptoms in three other patients. Foodborne botulism presenting as diplopia and unilateral motility deficits is rare and can represent a diagnostic and therapeutic challenge to the ophthalmologist.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diplopia as the primary presentation of foodborne botulism

Khakshoor¹,

Moghaddam²,

Vejdani³

et al. 2012

Oman J Ophthalmol

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“…La pupila de Adie se contrae a dosis bajas de pilocarpina 0,125%, mientras que una parálisis del III nervio lo suele hacer a dosis más altas. Estas dos últimas patologías son unilaterales con más frecuencia que la midriasis farmacológica (3 ción, ya que esto lo provocan los bloqueos parasimpáticos (4,5).…”

Section: Discussionunclassified

Botulismo simultáneo en dos hermanos cocainómanos

Aguirre-Balsalobre¹,

González-Herrera²,

Mengual-Verdú³

et al. 2007

Arch Soc Esp Oftalmol

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“…Some complain of nonspecifi c dizziness (not vertigo) or a dry sore throat. On examination, the blurred vision is usually from poor accommodation [23]. Pupils may not be dilated early.…”

Section: Clinical Featuresmentioning

confidence: 99%

Wound botulism from heroin skin popping

Davis

King²

2008

Curr Neurol Neurosci Rep

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Following the introduction of black tar heroin mainly from Mexico in the 1980s, cases of wound botulism dramatically increased in the western United States. Contamination with spores of Clostridium botulinum of black tar heroin occurs along the distribution line. The heating of heroin powder to solubilize it for subcutaneous injection ("skin popping") does not kill the spores. The spores germinate in an anaerobic tissue environment and release botulinum toxin type A or B. Unless skin abscesses are found in the patient, the clinical diagnosis is often challenging. Facilitation of the compound muscle action potential by repetitive nerve stimulation at 20 to 50 Hz is an important and rapid diagnostic test. Definite diagnosis is made by detection of botulinum toxin in serum or isolation of C botulinum from the abscess. Early treatment with equine ABE botulinum antitoxin obtained from the Centers for Disease Control and Prevention often shortens the time on a ventilator.

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Ophthalmic Manifestations in 18 Patients with Botulism Diagnosed in Porto, Portugal Between 1998 and 2003

Abstract: Ophthalmic manifestations were among the earliest and most prominent manifestations of botulism in this series, as in earlier reports. The diagnosis should be suspected when impaired accommodation and gastrointestinal symptoms occur together.

Cited by 19 publications

References 9 publications

Diplopia as the primary presentation of foodborne botulism

Diplopia as the primary presentation of foodborne botulism

Botulismo simultáneo en dos hermanos cocainómanos

Wound botulism from heroin skin popping

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