Ophthalmic antibiotic use for acute infectious conjunctivitis in children

Frost, Holly M; Sebastian, Thresia; Durfee, Josh; Jenkins, Timothy C

doi:10.1016/j.jaapos.2021.06.006

Cited by 11 publications

(11 citation statements)

References 37 publications

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“…Differences were found in the most frequently used type of antibiotic. In the present report, a quarter of the patients were prescribed neomycin with polymyxin B and glucocorticoid; this is in contrast with other reports, in which other antibiotics predominated [7,[12][13][14][18][19][20][21]. For example, the use of polymyxin B with trimethoprim predominated in the USA (53.4%) [12], whereas it was prescribed with fusidic acid in the Netherlands (69.0%) [14], levo oxacin in China (71.8%)…”

Section: Discussioncontrasting

confidence: 99%

“…We observed that ophthalmic antibiotics were prescribed for more than one third of patients, including a large proportion of those with viral and unspeci ed conjunctivitis and a smaller proportion of patients with allergic conjunctivitis, for which clinical practice guidelines do not recommend the use of antibiotics [8,9,11]. However, the rate of antibiotics prescriptions for acute conjunctivitis is higher in countries such as the USA (58.0-72.7%) [6,12], Australia (74.0%) [13],…”

Section: Discussionmentioning

confidence: 99%

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Indication-prescription study for the management of conjunctivitis in a Colombian population

Valladales‐Restrepo

Machado‐Duque

Gaviria‐Mendoza

et al. 2022

Preprint

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Purpose: Conjunctivitis is one of the most common ocular pathologies. Its treatment depends on its etiology, but an excessive use of antibiotics and corticosteroids, which in many cases are contraindicated, has been described. The objective was to describe the prescription patterns of medications used to treat conjunctivitis in a Colombian population.Methods: This was a cross-sectional study on the pharmacological treatment of patients diagnosed with conjunctivitis based on a drug-dispensing database of approximately 8.5 million people affiliated with the Colombian Health System. Some sociodemographic and pharmacological variables and comorbidities were considered. A descriptive analysis was performed.Results: A total of 8,708 patients were identified; they had a median age of 44.7 years, and 59.3% were women. The most common causes of conjunctivitis were unspecified (53.1%) and allergic (37.4%). The most commonly used drug was olopatadine (26.1%), followed by dexamethasone with neomycin and polymyxin B (25.0%). A total of 97.0% of the patients received ophthalmic prescriptions, while 12.8% received systemic medications. Glucocorticoids (40.3%), antibiotics (37.7%) and antihistamines (31.7%) were the most commonly used groups of ophthalmic drugs. Glucocorticoids and ophthalmic antibiotics were the medications most frequently prescribed by general practitioners for the treatment of viral or bacterial conjunctivitis.Conclusions: Many patients with conjunctivitis are not being managed according to the recommendations of clinical practice guidelines, which highlights that the widespread use of antibiotics with ophthalmic glucocorticoids could be considered potentially inappropriate prescriptions in many cases.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Indication-prescription study for the management of conjunctivitis in a Colombian population

Valladales‐Restrepo

Machado‐Duque

Gaviria‐Mendoza

et al. 2022

Preprint

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show abstract

“…In the present report, a quarter of the patients were prescribed neomycin with polymyxin B and glucocorticoid; this is in contrast with other reports, in which other antibiotics predominated [7,[15][16][17][21][22][23][24]. For example, the use of polymyxin B with trimethoprim predominated in the USA (53.4%) [15], whereas it was prescribed with fusidic acid in the Netherlands (69.0%) [17], levofloxacin in China (71.8%) [21], chloramphenicol in Australia (50.8%) [16], moxifloxacin in India (52.0-53.5%) [23,24] and tobramycin in Spain (66.1%) [22] and Belgium (23.4%) [7]. The differences in drug prescription patterns have been shown in other pharmacoepidemiological studies in the country, but in different clinical contexts [25][26][27].…”

Section: Discussioncontrasting

confidence: 99%

“…We observed that ophthalmic antibiotics were prescribed for more than one third of patients, including a large proportion of those with viral and unspecified conjunctivitis and a smaller proportion of patients with allergic conjunctivitis, for which clinical practice guidelines do not recommend the use of antibiotics [8,9,14]. However, the rate of antibiotics prescriptions for acute conjunctivitis is higher in countries such as the USA (58.0-72.7%) [6,15], Australia (74.0%) [16], Holland (80.0%) [17] and Belgium (89.4%) [7] and lower in different Scandinavian countries (4.2-21.1%) [18]. The present analysis found that the majority of prescriptions were issued by general practitioners, which is consistent with the reports of other publications [6,[15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…However, the rate of antibiotics prescriptions for acute conjunctivitis is higher in countries such as the USA (58.0-72.7%) [6,15], Australia (74.0%) [16], Holland (80.0%) [17] and Belgium (89.4%) [7] and lower in different Scandinavian countries (4.2-21.1%) [18]. The present analysis found that the majority of prescriptions were issued by general practitioners, which is consistent with the reports of other publications [6,[15][16][17]. For example, in England, Everitt et alsurveyed general practitioners and found that 95.0% prescribed antibiotics for the management of acute infectious conjunctivitis, but 58.0% of professionals believed that half of their patients had a viral infection [19].…”

Section: Discussionmentioning

confidence: 99%

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Indication-prescription study for the management of conjunctivitis in a Colombian population

et al. 2022

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pharmacological variables and comorbidities were considered. A descriptive analysis was performed. Results A total of 8708 patients were identified; they had a median age of 44.7 years, and 59.3% were women. The most common causes of conjunctivitis were unspecified (53.1%) and allergic (37.4%). The most commonly used drug was olopatadine (26.1%), followed by dexamethasone with neomycin and polymyxin B (25.0%). A total of 97.0% of the patients received ophthalmic prescriptions, while 12.8% received systemic medications. Glucocorticoids (40.3%), antibiotics (37.7%) and antihistamines (31.7%) were the most commonly used groups of ophthalmic drugs. Glucocorticoids and ophthalmic antibiotics were the medications most frequently prescribed by general practitioners for the treatment of viral or bacterial conjunctivitis.

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Antibiotic Treatment and Health Care Use in Children and Adolescents With Conjunctivitis

Shapiro,

Geanacopoulos,

Subramanian

et al. 2024

JAMA Ophthalmol

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Ophthalmic antibiotic use for acute infectious conjunctivitis in children

Cited by 11 publications

References 37 publications

Indication-prescription study for the management of conjunctivitis in a Colombian population

Indication-prescription study for the management of conjunctivitis in a Colombian population

Indication-prescription study for the management of conjunctivitis in a Colombian population

Antibiotic Treatment and Health Care Use in Children and Adolescents With Conjunctivitis

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