Operative versus non-operative treatment in diabetic dry toe gangrene

Wahbi, Abdullah Al

doi:10.1016/j.dsx.2018.12.021

Cited by 15 publications

(8 citation statements)

References 31 publications

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“…At the same time, it is necessary to educate the patients on the knowledge of diabetes and local braking, to change the dressing of the wound regularly in 5 Computational and Mathematical Methods in Medicine the process of nursing, to avoid friction and weight-bearing, to control the patient's diet, and to take careful care of the patient. It can effectively promote the rehabilitation of patients [25]. This study systematically, quantitatively, and comprehensively analyzed the results of multiple independent studies of the same type through meta-analysis.…”

Section: Analysis and Discussionmentioning

confidence: 99%

Effect of Nursing Intervention on Promoting Healing of RW in Patients with Diabetic Foot: A Systematic Review and Meta-Analysis

Chen

Xiao-xia

Zhang

2022

Computational and Mathematical Methods in Medicine

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Objective. To systematically assess the effect of nursing intervention on promoting the healing of refractory wounds (RW) in patients with diabetic foot (DF). Methods. A computer search of PubMed, EMBASE, ScienceDirect, CochraneLibrary, China knowledge Network Database (CNKI), China VIP Database, Wanfang Database, and China Biomedical Literature Database (CBM) online database was conducted in a randomized controlled trial (RCT) of traditional Chinese and western medicine nursing intervention on patients with RW of DF. Retrieval time was limited to the period from the date the database was established to present. Separately, two researchers gathered the data. RevMan5.3 statistical software was used to analyze the collected data by meta-analysis according to Cochrane Handbook 5.3. Results. Finally, 8 articles were included with a total sample size of 772 cases. The meta-analysis of the wound healing time after intervention indicated that the wound healing time of the study group was notably shorter, and the difference was statistically significant ( P < 0.05 ). Qualitative, fixed-effect model analysis indicated that the nursing effective rate after treatment in the study group was notably higher, and the difference was statistically significant ( P < 0.05 ). Fasting blood glucose level in the study group after treatment was notably lower, and the difference was statistically significant ( P < 0.05 ). The life quality in the study group was notably higher, and the difference was statistically significant ( P < 0.05 ). Further subgroup analysis indicated that the score of physical function (PF), emotional function (RE), social function (SF), physical pain (BP), general health (GH), vitality (VT), and mental health (MH) in the study group were higher, and the difference was statistically significant ( P < 0.05 ). A publication bias analysis was conducted using the inverted funnel chart as the outcome indicator for this study. The results indicated that most of the funnel maps were symmetrical and a few were asymmetrical, suggesting that there exhibited a certain publication bias in the included literature. Conclusion. The application of traditional Chinese and western medicine nursing intervention when treating DF patients clinically can effectively promote the healing of foot ulcer wounds. Traditional Chinese and western medicine nursing can help patients heal wounds faster and enhance their life quality compared to simplistic western medicine nursing. According to the original literature, the conclusion deserves to be popularized in clinic.

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Section: Analysis and Discussionmentioning

confidence: 99%

Effect of Nursing Intervention on Promoting Healing of RW in Patients with Diabetic Foot: A Systematic Review and Meta-Analysis

Chen

Xiao-xia

Zhang

2022

Computational and Mathematical Methods in Medicine

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“…The International Journal of Lower Extremity Wounds 20 (2)…”

Section: Acknowledgmentsmentioning

confidence: 99%

“…1 Neuropathy and poor blood circulation caused by hyperglycemia increase the probability of necrotizing fasciitis (NF) in the legs. 2 NF is a serious, rapidly progressive, and critical soft tissue infectious disease that is characterized by progressive necrosis involving deep, superficial fascia, and subcutaneous tissue. 3 The STAGE principles guide surgical intervention for the treatment of DFUs.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Diabetic Foot Ulcers With Necrotizing Fasciitis in the Lower Leg Using the STAGE Principles: A Report of 9 Cases With a Literature Review

Tian

Sun

Zhu

et al. 2020

The International Journal of Lower Extremity Wounds

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Diabetic foot ulcers (DFUs) combined with necrotizing fasciitis (NF) has rapid onset, involves a wide range of lesions, is difficult to treat, and has a high mortality rate. It has become a clinically critical disease. DFU patients are at high risk for NF. The STAGE principles guide surgical intervention in the treatment of DFU wounds and emphasizes that “based on anatomical layers, the management focuses on blood supply and includes layer-by-layer incision to the infected area, maintenance of effective wound drainage, and step-by-step treatment of the wound.” This work reports the application of the STAGE principles for the treatment of 9 cases of DFUs combined with NF in the lower leg (Wagner grade 3-5). The mean ankle-brachial index was 0.55 (0-0.91, standard deviation [SD] = 0.33), the mean years of smoking were 19.56 years (0-50, SD = 17.83), and the mean cigarette consumption was 9.11 cigarettes/day (0-20, SD = 7.77). The mean duration of ulcers was 45.56 days (3-103, SD = 35.44). Among the 9 patients, only patient no. 9 died, and the mean follow-up time for the other 8 patients was 12 months (3-36, SD = 13.42). In short, the STAGE principles are also applicable to the treatment of DFUs combined with NF in the lower leg.

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“… 2 Non-healing diabetic wounds, especially those in the lower extremities, are common complications, and are called diabetic foot ulcer (DFU), which lead to 15–25% of diabetes patients needing amputation and suffering from disability during their lifetimes. 3 , 4 Normal wound healing is a dynamic and complicated biological process involving four typical phases: hemostasis, inflammation, proliferation and remodeling, in which many types of cells, cytokines and the extracellular matrix (ECM) are involved ( Figure 1 ). 5–7 However, a wound with a micro-environment featuring high glycemic levels is more easily infected by bacteria, and macrophages produce more reactive oxygen species (ROS) to defend against foreign pathogens.…”

Section: Introductionmentioning

confidence: 99%

Efficiency of Multifunctional Antibacterial Hydrogels for Chronic Wound Healing in Diabetes: A Comprehensive Review

Ji¹,

Ren²,

Weng³

2022

IJN

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Diabetic chronic wounds or amputation, which are complications of diabetes mellitus (DM), are a cause of great suffering for diabetics. In addition to the lack of oxygen, elevated reactive oxygen species (ROS) and reduced vascularization, microbial invasion is also a critical factor that induces non-healing chronic diabetic wounds, ie, wounds still remaining in the stage of inflammation, after which the wound tissue begins to age and becomes necrotic. To clear up the infection, alleviate the inflammation in the wound and prevent necrosis, many kinds of hydrogel have been fabricated to eliminate infections with pathogens. The unique properties of hydrogels make them ideally suited to wound dressings because they provide a moist environment for wound healing and act as a barrier against bacteria. This review article will mainly cover the recent developments and innovations of antibacterial hydrogels for diabetic chronic wound healing.

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Operative versus non-operative treatment in diabetic dry toe gangrene

Cited by 15 publications

References 31 publications

Effect of Nursing Intervention on Promoting Healing of RW in Patients with Diabetic Foot: A Systematic Review and Meta-Analysis

Effect of Nursing Intervention on Promoting Healing of RW in Patients with Diabetic Foot: A Systematic Review and Meta-Analysis

Treatment of Diabetic Foot Ulcers With Necrotizing Fasciitis in the Lower Leg Using the STAGE Principles: A Report of 9 Cases With a Literature Review

Efficiency of Multifunctional Antibacterial Hydrogels for Chronic Wound Healing in Diabetes: A Comprehensive Review

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