Operative Behandlung von primären und sekundären diffusen Pleuratumoren

Schuster, G.; Huzly, A

doi:10.1055/s-0028-1102796

Cited by 2 publications

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“…The classification into epithelioid-carcinomatous, mesenchymal-sarcomatous and mixed bi-phased has been in use since 1931 [1], No curative approach has been established to date. Tumour decortication involving pleurectomy is thus obviously the therapie of choice [5,6,14,15]. In addition to its palliative effects such as pain relief and elimination of effusions, this is the only way to obtain a definite diagnosis apart from diag nostic thoracoscopy.…”

Section: Discussionmentioning

confidence: 99%

“…Accompanying chemotherapy can improve the prognosis. Thanks to this combined therapy, average survival was up to 27 months [11,[14][15][16][17]. Diverse studies claim that treatment with cisplatin in particular can improve the prognosis [10, 148 Taleb/Graupe/Sonak Intra-Arterial Perfusion of Diffuse Pleural Mesothelioma 18-20], In this context, both intrapleural and systemic applica tion of cisplatin resulted in highly promising remission rates [20,21],…”

Section: Discussionmentioning

confidence: 99%

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lntra-Arterial Perfusion of Diffuse Pleural Mesothelioma – an Alternative Management for Inoperable Cases

Taleb¹,

Graupe

Sonak

1995

Oncol Res Treat

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Background: The prognosis of diffuse pleural mesothelioma remains unfavourable, with or without therapy. And no curative approach has been established to date. At present, tumour decortication involving pleurectomy is the therapy of choice for younger patients at a favourable stage of tumour formation and histology. The role of oncological therapy for patients with inoperable progression of the disease is unsatisfactory and still subject to controversial discussion. Patient and Method: We report on a management concept combining radiation and direct intra-arterial perfusion of cisplatin and mitoxantrone for primary inoperable pleural mesothelioma showing diffuse growth at an advanced stage and on the clinical progression. In the course of treatment the truncus costobronchialis and the 5th ot 12th intercostal artery of the left hemithorax were selected with various frequencies and used for chemotherapy. Result: Management consisted of 11 intra-arterial perfusions of the left hemithorax using mitoxantrone and cisplatin, accompanied by radiation with a total focal dosage of 46 Gy (Linac). Due to this therapy regime the patient survived for 28 months, enjoying a good quality of life. Conclusion: The case reported suggests that such a therapy approach combining intra-arterial, direct perfusion with radiotherapy for the management of pronounced and irreversible manifestations of pleural mesothelioma (stage IV) is effective even from a palliative point of view. Thus we consider it highly recommendable as compared to alternative therapies, regarding the resultant quality of life and life expectancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

lntra-Arterial Perfusion of Diffuse Pleural Mesothelioma – an Alternative Management for Inoperable Cases

Taleb¹,

Graupe

Sonak

1995

Oncol Res Treat

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Das Pleuramesotheliom ? Probleme in der Diagnostik und klinischer Verlauf bei 25 Patienten

Liewald¹,

Sunder‐Plassmann²,

Dienemann³

et al. 1989

Langenbecks Arch Chiv

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Patients with benign pleurafibromas should undergo surgery as suspect thoracic tumors have the potential to become malignant. In benign cases diagnosis can easily be made during the operation. In such a case the prognosis is good and it is seldom necessary to undergo repeated surgery due to recurrence. In the case of malignant pleuramesothelioma the preoperative diagnosis with an exact staging of the tumor is very important to determine an adequate therapeutic regimen. X-ray, CT-scanning, tapping of the pleura fluid and biopsy of the pleura are together insufficient to diagnose a pleuramesothelioma correctly. Since it is not always possible to diagnose a malignant pleuramesothelioma even at thoracoscopy, one should not hesitate to perform an open lung biopsy in order to obtain enough material under adequate vision.

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Operative Behandlung von primären und sekundären diffusen Pleuratumoren

Cited by 2 publications

References 0 publications

lntra-Arterial Perfusion of Diffuse Pleural Mesothelioma – an Alternative Management for Inoperable Cases

lntra-Arterial Perfusion of Diffuse Pleural Mesothelioma – an Alternative Management for Inoperable Cases

Das Pleuramesotheliom ? Probleme in der Diagnostik und klinischer Verlauf bei 25 Patienten

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