Operationally simple green synthesis of some Schiff bases using grinding chemistry technique and evaluation of antimicrobial activities

Sachdeva, Harshita; Saroj, Rekha; Khaturia, Sarita; Dwivedi, Diksha

doi:10.1515/gps-2012-0043

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…In continuation of our work to develop green methodologies for the synthesis of organic compounds [33][34][35][36], herein we wish to report a mild and highly efficient procedure for the synthesis of 3-[1-(5-amino-[1,3,4]-thiadiazol-2yl)substitutedethylimino]-5-substituted-2,3-dihydro-indol-2-one derivatives (4) using water as a green solvent and citric acid as a green catalyst (Scheme 1). 4 was synthesized by the one-pot multicomponent condensation reaction of substituted 1H-indole-2,3diones (1), various amino acids (2), and thiosemicarbazide (3) in the presence of lemon juice.…”

Section: Resultsmentioning

confidence: 99%

Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and Evaluation of Cytotoxic Effects

Sachdeva

Saroj

Khaturia

et al. 2014

Journal of Chemistry

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Green chemical one-pot multicomponent condensation reaction of substituted 1H-indole-2,3-diones (1), various amino acids (2), and thiosemicarbazide (3) is found to be catalyzed by lemon juice as natural acid using water as a green solvent to give the corresponding Schiff bases (4) in good to excellent yields. This method is experimentally simple, clean, high yielding, and green, with reduced reaction times. The product is purified by simple filtration followed by washing with water and drying process. The synthesized compounds are characterized by FT-IR,13CNMR, and1HNMR spectroscopy and are screened for their antifungal activity againstAspergillus niger,Penicillium notatum,Fusarium oxysporum,Alternaria brassicicola,Chaetomium orium, andLycopodium sp.and antibacterial activity against Gram-positive bacteria,Bacillus licheniformis,Staphylococcus aureus, andMicrococcus luteus,and Gram-negative bacteria,Pseudomonas aeruginosaandEscherichia coli. Compounds have also been evaluated for cytotoxic effects against human colon cancer cell line Colo205.

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Section: Resultsmentioning

confidence: 99%

Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and Evaluation of Cytotoxic Effects

Sachdeva

Saroj

Khaturia

et al. 2014

Journal of Chemistry

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“…In continuation of our work to develop greener and expeditious protocols for the synthesis of heterocyclic compounds [44][45][46][47][48], herein we wish to report a highly efficient procedure for the synthesis of new substituted-2H-1,2,4-triazole phenol derivatives (4) and spiro (indole-triazole) propanoic acid derivatives (5) using water (containing 1-2 mL of alcohol) by the reaction of 4-chloro-2-nitro aniline (1)/amino acids (1 ) and aromatic aldehydes (2)/1H indole-2,3-diones (2 ), respectively, with thiosemicarbazide (3) yielding triazole (4)/spiro indole-triazole (5) derivatives in high yields and shorter reaction displaying excellent florescent property (Scheme 1).…”

Section: Resultsmentioning

confidence: 99%

Environ-Economic Synthesis and Characterization of Some New 1,2,4-Triazole Derivatives as Organic Fluorescent Materials and Potent Fungicidal Agents

Sachdeva

Saroj

Khaturia

et al. 2013

Organic Chemistry International

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A multicomponent one-pot clean cyclocondensation reaction of 4-chloro-2-nitro aniline/amino acids and aromatic aldehydes/ indole-2,3-diones with thiosemicarbazide in water yielding triazole/spiro indole-triazole derivatives in high yields and shorter reaction time and displaying excellent florescent property is reported. The developed MCR may provide a valuable practical tool for the synthesis of new drugs containing the title core fragment. All the newly synthesized compounds have been characterized by IR, 1 HNMR, 13 CNMR, and fluorescence study and also been screened for antimicrobial activity.

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“…In the laboratory, it is typically used with an ultrasonic bath or probe; this apparatus is known as a sonicator. A new approach for [44].…”

Section: Synthetic Methods Of Schiff Basesmentioning

confidence: 99%

Schiff Bases and Their Metal Complexes: Synthesis, Structural Characteristics and Applications

Meena¹,

Meena²,

Kumari³

et al. 2023

Schiff Base in Organic, Inorganic and Physical Chemistry

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The development of Schiff base was a major step forward in the area of coordination chemistry. Schiff bases, a class of organic compounds, carry the imine or azomethine (>C=N–) functional group. Schiff bases played an influencing role in the development of coordination chemistry and were a key point in the development of inorganic, bioinorganic chemistry and optical materials. Schiff bases, widely used in inorganic, organic, and analytical chemistry, account for a significant portion of the more commonly employed classes of organic molecules. The ability of Schiff base ligands to form stable metal complexes with a wide range of transition and other metal ions makes them extremely useful. Condensation of a primary amine with an aldehyde or ketone yields a Schiff bases. In this chapter, we focused on introducing Schiff bases, classified them and their metal complexes, and discussed several synthesis methods, including conventional and green approaches. This chapter also elaborated on the industries’ applications, such as the food industry, agrochemical industry, dye industry, analytical chemistry, catalysis, energy storage, environmental, chemo-sensing, bio-sensing, and biomedical applications of novel Schiff bases and their metal complexes.

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Operationally simple green synthesis of some Schiff bases using grinding chemistry technique and evaluation of antimicrobial activities

Cited by 5 publications

References 19 publications

Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and Evaluation of Cytotoxic Effects

Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and Evaluation of Cytotoxic Effects

Environ-Economic Synthesis and Characterization of Some New 1,2,4-Triazole Derivatives as Organic Fluorescent Materials and Potent Fungicidal Agents

Schiff Bases and Their Metal Complexes: Synthesis, Structural Characteristics and Applications

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