Operational Procedures in the Theory of the Drug Release from Chitosan Hydrogels

Craciun, Anda Mihaela; Șerban, Georgiana; Crumpei, Iulia; Agop, Maricel; Cioca, Gabriela

doi:10.37358/mp.18.4.5080

Cited by 2 publications

(2 citation statements)

References 13 publications

(21 reference statements)

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“…Pellets of drug delivery samples with a mass of 62 mg were immersed in a volume of 10 mL PBS and kept at 37 °C. At certain times, 2 mL of supernatant was removed from the vials and replaced with PBS, maintaining a constant volume of 10 mL [ 23 , 24 ]. The concentration of the drug in the supernatant was determined by UV-Vis spectroscopy, according to Lambert–Beer law, using the maximum of absorbance from 275 nm, and fitting the value on a previously drawn calibration curve.…”

Section: Methodsmentioning

confidence: 99%

Hydrogels Based on Imino-Chitosan Amphiphiles as a Matrix for Drug Delivery Systems

Ailincai¹,

Porzio

Marin³

2020

Polymers

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This paper reports new formulations based on chitosan, citral, and diclofenac sodium salt (DCF). The central idea was to encapsulate an anionic drug into a polycationic hydrogel matrix in order to increase the intermolecular forces between them and thus to ensure slower drug release, while citral was used as a penetration enhancer to assure efficient delivery of the drug. Hydrogels without drug were also synthesized and used as a reference. The structure, morphology, and supramolecular architecture of the drug delivery systems were evaluated by FTIR spectroscopy, scanning electron microscopy, polarized optical microscopy, and wide-angle X-ray diffraction. The drug release kinetics was monitored in vitro by UV-VIS spectroscopy, in physiological conditions, while the enzymatic and hydrolytic degradability of the hydrogels were evaluated in the presence of lysozyme and phosphate buffer saline (PBS), at 37 °C. All of the data revealed that the anionic DCF was strongly anchored into the polycationic matrix and the drug was slowly released over 7 days. Moreover, the release rate can be controlled by simple variation of the molar ratio between the polycationic chitosan and lipophilic citral.

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Section: Methodsmentioning

confidence: 99%

Hydrogels Based on Imino-Chitosan Amphiphiles as a Matrix for Drug Delivery Systems

Ailincai¹,

Porzio

Marin³

2020

Polymers

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“…Moreover, the innate thixotropy of the gels permits their targeted injection and sets the bases for a prolonged local release at the injection site (in this case, the peritoneal cavity), which assures the much-desired combination of maximum local effect and minimum overall side effects. The drug release behavior, as followed by UV–Vis and various theoretical mathematic models, consists of a prolonged, diffusion-controlled mechanism starting from the outer layers of the hydrogels [ 101 ]. The system with the lowest citral concentration acted as the best drug reservoir, releasing roughly 65% of the anticancer reagent in 32 h. The chitosan-based matrices showed in vivo side effects that were comparable and most likely belonging to the pure drug and a lysozyme-triggered enzymatic degradation (11% mass loss after 21 days).…”

Section: Glycodynameric Gels For Drug Deliverymentioning

confidence: 99%

Smart Supra- and Macro-Molecular Tools for Biomedical Applications

2020

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Stimuli-responsive, “smart” polymeric materials used in the biomedical field function in a bio-mimicking manner by providing a non-linear response to triggers coming from a physiological microenvironment or other external source. They are built based on various chemical, physical, and biological tools that enable pH and/or temperature-stimulated changes in structural or physicochemical attributes, like shape, volume, solubility, supramolecular arrangement, and others. This review touches on some particular developments on the topic of stimuli-sensitive molecular tools for biomedical applications. Design and mechanistic details are provided concerning the smart synthetic instruments that are employed to prepare supra- and macro-molecular architectures with specific responses to external stimuli. Five major themes are approached: (i) temperature- and pH-responsive systems for controlled drug delivery; (ii) glycodynameric hydrogels for drug delivery; (iii) polymeric non-viral vectors for gene delivery; (iv) metallic nanoconjugates for biomedical applications; and, (v) smart organic tools for biomedical imaging.

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Operational Procedures in the Theory of the Drug Release from Chitosan Hydrogels

Cited by 2 publications

References 13 publications

Hydrogels Based on Imino-Chitosan Amphiphiles as a Matrix for Drug Delivery Systems

Hydrogels Based on Imino-Chitosan Amphiphiles as a Matrix for Drug Delivery Systems

Smart Supra- and Macro-Molecular Tools for Biomedical Applications

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