Open-Label, 8-Week Trial of Olanzapine and Risperidone for the Treatment of Bipolar Disorder in Preschool-Age Children

Biederman, Joseph; Mick, Eric; Hammerness, Paul; Harpold, Theresa; Aleardi, Megan; Dougherty, Meghan; Wozniak, Janet

doi:10.1016/j.biopsych.2005.03.019

Cited by 143 publications

(89 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An open-label comparison trial examined the efficacy of olanzapine versus risperidone for the treatment of bipolar disorder in preschool-aged children [57]. This was an 8-week trial, including 31 children aged 4-6 years with a diagnosis of bipolar disorder type I, type II, or not otherwise specified.…”

Section: Atypical Antipsychoticsmentioning

confidence: 99%

The Treatment of Preschool Mood Disorders

DeFilippis

Wagner

2015

Curr Treat Options Psych

View full text Add to dashboard Cite

Section: Atypical Antipsychoticsmentioning

confidence: 99%

The Treatment of Preschool Mood Disorders

DeFilippis

Wagner

2015

Curr Treat Options Psych

View full text Add to dashboard Cite

“…ADHD onset prior to BD symptoms and a Young Mania Rating Scale (YMRS) 21 score . 15 were required at the baseline visit 22 for the group with comorbid BD and ADHD. Exclusion criteria were use of psychotropic medication 4 weeks prior to entering the study; diagnoses of pervasive development disorder, schizophrenia, substance abuse or dependence, or mental retardation (estimated IQ: , 70); severe suicide/homicide risk counter-indicating outpatient treatment; any other acute or chronic disease; and pregnancy.…”

Section: Diagnostic Procedures and Data Collectionmentioning

confidence: 99%

Does comorbid bipolar disorder increase neuropsychological impairment in children and adolescents with ADHD?

Narvaez

Zeni

Coelho

et al. 2014

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: To assess differences in executive functioning between children and adolescents with attention-deficit/hyperactivity disorder (ADHD) comorbid or not with bipolar disorder (BD), and to study the neuropsychological profile of subjects with the comorbidity in a clinical sample from a developing country. Method: Case-control study comparing 23 participants with BD + ADHD and 85 ADHD-only subjects aged 6 to 17 years old. Both groups were drug-free. Executive function domains were assessed with the Stroop Test, the Wisconsin Card Sorting Test, and the Continuous Performance Test II. Results: The group with juvenile BD + ADHD showed a significantly worse performance on the Stroop task, including time in color (p = 0.002), time in color-word (p , 0.001), interference, number or errors in color and color-word (p = 0.001), and number of errors in word cards (p = 0.028). No between-group differences were found in other tests. Conclusions: Our findings suggest that ADHD-only and ADHD + BD do not show differences in inhibitory control and set-shifting domains. However, children and adolescents with BD and comorbid ADHD show greater impairment in processing speed and interference control. This suggests a potentially higher impairment in the dorsolateral prefrontal cortex and may be a potential neuropsychological signature of juvenile BD comorbid with ADHD.

show abstract

“…Data are summarized in Table 2. [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] Case reports and case series were detected, but were not included in the text due to the availability of higher-level evidence for the psychopharmacological agents of interest. Nevertheless, we recommend analysis of these case series and reports, which are available from the authors on request.…”

Section: Randomized Controlled Trials/meta-analysesmentioning

confidence: 99%

“…53 The primary efficacy measures were a reduction o 30% in the YMRS and improvement in the CGI scale. Both antipsychotics proved to be effective in reducing manic symptoms.…”

Section: **mentioning

confidence: 99%

Pharmacotherapy of bipolar disorder in children and adolescents: an update

Peruzzolo

Tramontina

Rohde

et al. 2013

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: To review the options for acute and maintenance pharmacological treatment of bipolar disorder in children and adolescents, including the treatment of bipolar depression and comorbid attention deficit/hyperactivity disorder (ADHD). Methods: Narrative review of randomized clinical trials and open-label studies published from 2000 to 2012. The PubMed and PsycINFO websites were queried. Case series were included when a higher level of evidence was not available. Results: Published data from randomized controlled trials (RCTs) in acute mania/hypomania with significant responses are available for lithium, topiramate, risperidone, olanzapine, and aripiprazole. Open trials of lithium and lamotrigine show that these drugs may be effective in the treatment of depressive episodes. No trials of selective serotonin reuptake inhibitors (SSRIs) have been conducted. In the treatment of comorbid ADHD, there are encouraging findings with mixed amphetamine salts and atomoxetine; conflicting results are observed with methylphenidate. Conclusions: Published RCTs of traditional mood stabilizers are scarce, but the best available evidence (results from meta-analytic regression) suggests that second-generation antipsychotics (SGAs) as a group are more effective in reducing manic symptoms. Risperidone was the only one included in head-to-head comparisons (vs. lithium and divalproex), showing superiority in terms of efficacy, but with more metabolic side effects, which were also more common in most of the SGAs. There are few studies addressing the treatment of ADHD and depression. Brazilian guidelines for the treatment of pediatric bipolar disorder should also include some SGAs (especially risperidone and aripiprazole) as first-line treatment, and these drugs should be provided by the public health services.

show abstract

Open-Label, 8-Week Trial of Olanzapine and Risperidone for the Treatment of Bipolar Disorder in Preschool-Age Children

Cited by 143 publications

References 14 publications

The Treatment of Preschool Mood Disorders

The Treatment of Preschool Mood Disorders

Does comorbid bipolar disorder increase neuropsychological impairment in children and adolescents with ADHD?

Pharmacotherapy of bipolar disorder in children and adolescents: an update

Contact Info

Product

Resources

About