Open-Field Behavior in Aging Inbred Mice

Sprott, Richard L.; Eleftheriou, Basil E.

doi:10.1159/000212009

Cited by 78 publications

(26 citation statements)

References 9 publications

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“…The number of rearings also was slightly reduced in old rats. The overall decline in locomotor activity observed in our study is a commonly observed aging deficit (26,(71)(72)(73). It is well known that aging is accompanied by decreases in both quantity and quality of motor activity in humans and in animals (74,75).…”

Section: Discussionsupporting

confidence: 68%

A High-Salt Diet Further Impairs Age-Associated Declines in Cognitive, Behavioral, and Cardiovascular Functions in Male Fischer Brown Norway Rats

Chugh

Asghar

Patki

et al. 2013

The Journal of Nutrition

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Aging-associated declines in cognitive, emotional, and cardiovascular function are well known. Environmental stress triggers critical changes in the brain, further compromising cardiovascular and behavioral health during aging. Excessive dietary salt intake is one such stressor. Here, we tested the effect of high salt (HS) on anxiety, learning-memory function, and blood pressure (BP) in male Fischer brown Norway (FBN) rats. Adult (A; 2 mo) and old (O; 20 mo) male rats were fed normal-salt (NS; 0.4% NaCl) or HS (8% NaCl) diets for 4 wk after being implanted with telemeter probes for conscious BP measurement. Thereafter, tests to assess anxiety-like behavior and learning-memory were conducted. The rats were then killed, and samples of plasma, urine, and brain tissue were collected. We found that systolic BP was higher in O-NS (117 ± 1.2 mm Hg) than in A-NS (105 ± 0.8 mm Hg) rats (P < 0.05). Furthermore, BP was higher in O-HS (124 ± 1.4 mm Hg) than in O-NS (117 ± 1.2 mm Hg) rats (P < 0.05). Moreover, anxiety-like behavior (light-dark and open-field tests) was not different between A-NS and O-NS rats but was greater in O-HS rats than in A-NS, O-NS, or A-HS rats (P < 0.05). Short-term memory (radial arm water maze test) was similar in A-NS and O-NS rats but was significantly impaired in O-HS rats compared with A-NS, O-NS, or A-HS rats (P < 0.05). Furthermore, oxidative stress variables (in plasma, urine, and brain) as well as corticosterone (plasma) were greater in O-HS rats when compared with A-NS, O-NS, or A-HS rats (P < 0.05). The antioxidant enzyme glyoxalase-1 expression was selectively reduced in the hippocampus and amygdala of O-HS rats compared with A-NS, O-NS, or A-HS rats (P < 0.05), whereas other antioxidant enzymes, glutathione reductase 1, manganese superoxide dismutase (SOD), and Cu/Zn SOD remained unchanged. We suggest that salt-sensitive hypertension and behavioral derangement are associated with a redox imbalance in the brain of aged FBN rats.

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Section: Discussionsupporting

confidence: 68%

A High-Salt Diet Further Impairs Age-Associated Declines in Cognitive, Behavioral, and Cardiovascular Functions in Male Fischer Brown Norway Rats

Chugh

Asghar

Patki

et al. 2013

The Journal of Nutrition

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“…In addition to age-associated motor coordination decline; aging was associated with reduced activity in the open field, 34 and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease 35 in which mitochondrial apoptotic pathways play an important role in MPTP neurotoxicity. 36,37 The open-field test was used to assess locomotor activity in an open-field arena, and reduced activity in the center of the field was suggestive of anxiety.…”

Section: Discussionmentioning

confidence: 99%

D-Galactose Effectiveness in Modeling Aging and Therapeutic Antioxidant Treatment in Mice

Parameshwaran

Irwin

Steliou

et al. 2010

Rejuvenation Research

108

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Accumulating evidence suggests that mitochondrial dysfunction and oxidative stress play major roles in aging. Chronic administration of D-galactose has been reported to cause deterioration of cognitive and motor skills that are similar to symptoms of aging and, therefore, is regarded as a model of accelerated aging. Because enhancing endogenous antioxidants is now widely regarded as an attractive therapy for conditions associated with mitochondrial oxidative stress, in the present study the effects of a-lipoic acid, L-carnitine, and PMX-500F on D-galactose treated mice were tested. Female mice were injected with (100 mg/kg) D-(þ)-galactose for 6 weeks and some groups were treated with a daily dose of a-lipoic acid (5 mg/kg), L-carnitine (3.9 mg/kg), PMX-500F (11.9 mg/kg), or the vehicle (0.1 M Tris, pH 7.4). Control mice were treated with physiological saline. An accelerating Rota-Rod, open field test, and Y-maze test were performed, and serum lactate concentrations were analyzed. These analyses did not identify impairment in motor coordination, open-field activity, or spatial memory ( p > 0.05). Similarly, serum lactate concentrations in D-galactose-treated mice were not elevated when compared to controls ( p > 0.05). Treatment with the antioxidant compounds at the given concentrations did not result in any changes in the behavioral parameters tested. In conclusion, results of this study illustrate that chronic, short-term D-galactose treatment may not represent a suitable model for inducing readily detectable age-related neurobehavioral symptoms in mice.

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“…Although it is well known that aging in ani mals can lead to a decrease in horizontal motor activity [1][2][3][4][5][6][7][8][9][10][11][12], a good number of stud ies can be cited that have not found such a result [13][14][15][16][17][18][19]. On the contrary, in some cases, a decrease in habituation to motor activity was observed with aging [13,14].…”

Section: Exploration In Aging Animalsmentioning

confidence: 99%

Exploratory Drive, Frontal Lobe Function and Adipsia in Aging

Lalonde

Badescu²

1995

Gerontology

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Aging in animals in accompanied by a decrease in exploratory drive, as assessed by hole poking and spontaneous alternation tests. This decrease is caused either by increased fear of the novel testing environment (neophobia) or by apathy. Either cause may be related to dysfunction of prefrontal cortex-related pathways. The myelination of the prefrontal cortex appears late in ontogeny. In accordance to the last-in first-out principle, this brain region seems to be affected early during aging. It remains to be determined whether this decrease of exploratory behavior is reversible by behavioral intervention, by dietary changes or by the administration of psychotropic drugs. One hypothesis worth testing is whether the decrease in exploration is associated to the well-described adipsia in human aging, whose neurobiological basis has not yet been determined. It is possible to consider that the maladaptive response to thirst is responsible for some senescent changes in the brain and that reversal of adipsia by behavioral, dietary or pharmacological means improves the quality of life in the elderly.

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Open-Field Behavior in Aging Inbred Mice

Cited by 78 publications

References 9 publications

A High-Salt Diet Further Impairs Age-Associated Declines in Cognitive, Behavioral, and Cardiovascular Functions in Male Fischer Brown Norway Rats

A High-Salt Diet Further Impairs Age-Associated Declines in Cognitive, Behavioral, and Cardiovascular Functions in Male Fischer Brown Norway Rats

D-Galactose Effectiveness in Modeling Aging and Therapeutic Antioxidant Treatment in Mice

Exploratory Drive, Frontal Lobe Function and Adipsia in Aging

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