[OP.LB03.05] Reducing Arterial Stiffness Independently of Blood Pressure

Mills, CE; Govoni,; Faconti, Luca; Morant, S. V.; Ml, Casagrande; Maskell, Perry; Masani, A.; Crickmore, H.; Iqbal, Fahad; Webb, Alastair; Jk, Cruickshank

doi:10.1097/01.hjh.0000491627.59731.0f

Cited by 4 publications

(4 citation statements)

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“…In relation to this subject, a recent meta-analysis showed that currently there is insufficient evidence regarding the efficacy of regular exercise for improving vascular function and arterial stiffness as measured by flow mediated vasodilatation and PWV measurement in type 2 diabetes [69]. Based on the fact that arterial stiffness, measured as carotid–femoral PWV, is a strong prognostic factor, independent of classic risk factors, and that it could be an important treatment target, several studies investigated whether different nutritional and pharmacological interventions could reduce arterial stiffness independently of their effect on blood pressure or metabolic effects [70,71,72]. However, it is still unclear whether reducing arterial stiffness may improve the prognosis beyond treatment of standard cardiovascular risk factors.…”

Section: Possible Interventions Directed At Reducing Aortic Stiffnmentioning

confidence: 99%

Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes

Cardoso

Salles

2016

IJMS

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Increased aortic stiffness has been recognized as a predictor of adverse cardiovascular outcomes in some clinical conditions, such as in patients with arterial hypertension and end-stage renal disease, in population-based samples and, more recently, in type 2 diabetic patients. Patients with type 2 diabetes have higher aortic stiffness than non-diabetic individuals, and increased aortic stiffness has been correlated to the presence of micro- and macrovascular chronic diabetic complications. We aimed to review the current knowledge on the relationships between aortic stiffness and diabetic complications, their possible underlying physiopathological mechanisms, and their potential applications to clinical type 2 diabetes management.

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Section: Possible Interventions Directed At Reducing Aortic Stiffnmentioning

confidence: 99%

Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes

Cardoso

Salles

2016

IJMS

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“…Participants with or at risk of T2DM (n=126, 57±12 years) were randomized to spironolactone (12.5mg titrated to 25mg, twice daily) or doxazosin (4-8mg, twice daily) and dietary nitrate as 'Beet-it' beetroot juice (7.5mmol nitrate increased to 11.2mmol) or nitratefree 'Beet-it' juice, a specific placebo (2). Outcomes were primarily change in arterial stiffness as cardio-ankle vascular index (CAVI), a nominally BP-independent measure, secondarily aortic PWV by Arteriograph, with other haemodynamic parameters measured.…”

Section: Abbreviationsmentioning

confidence: 99%

Reducing Arterial Stiffness Independently of Blood Pressure

Mills¹,

Govoni²,

Faconti³

et al. 2017

Journal of the American College of Cardiology

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“…Although previous short term studies have suggested potential beneficial effects of beetroot juice as a form of dietary nitrate supplementation in healthy individuals, primary hypertensive and untreated hypercholesteraemic patients [10,12,19,30,31] and one 6 month long study has shown an improvement in central but not peripheral systolic blood pressure in people with or at risk from type II diabetes [14], the present trial, over 12 weeks, is the longest duration study of this intervention in COPD. Our findings are also broadly consistent with the largest RCT of dietary nitrate supplementation in COPD (The ON-EPIC study), which demonstrated a fall in SBP of 5±3.7mmHg with dietary nitrate supplementation over 8 weeks in people with COPD, conducted in the context of a pulmonary rehabilitation program [17].…”

Section: Significance Of Findingsmentioning

confidence: 82%

“…Dietary nitrate supplementation using NO3rich beetroot juice (BRJ) has received growing attention in cardiovascular and exercise research [8], though clinical data are scarce and studies to date have mostly been of short duration [9][10][11][12][13][14]. There has also been interest in the effect of BRJ in people with COPD, because of potential benefits on exercise capacity [15], particularly in hypoxic individuals [16], and in the context of pulmonary rehabilitation PR [17].…”

Section: Introductionmentioning

confidence: 99%

Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC, a randomised controlled trial

Alasmari,

Alsulayyim,

Alghamdi

et al. 2023

Eur Respir J

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BackgroundShort term studies suggest that dietary nitrate supplementation may improve cardiovascular risk profile, lowering blood pressure (BP) and enhancing endothelial function. It is not clear if these beneficial effects are sustained and whether they apply in people with COPD, who have a worse cardiovascular profile than those without COPD. Nitrate-rich beetroot juice BRJ (NR-BRJ) is a convenient dietary source of nitrate.MethodsThe ON-BC trial was a randomized, double-blind, placebo-controlled parallel group study in stable COPD patients with home systolic BP (SBP) measurement ≥130 mmHg. Participants were randomly allocated (1:1) using computer-generated, block randomization to either 70 mL of NR-BRJ (400 mg NO3−) (n=40) or an otherwise identical nitrate-depleted placebo juice Pl-BRJ (0 mg NO3−) (n=41), once daily for 12 weeks. The primary endpoint was between group change in home SBP measurement. Secondary outcomes included change in 6-minute walking distance (6MWD) and measures of endothelial function (reactive hyperaemia index (RHI) and augmentation index (AIx75)) using an EndoPAT device. Plasma nitrate and platelet function were also measured.ResultsCompared to placebo, active treatment lowered SBP (Hodges-Lemman treatment effect MD[95% CI]; −4.5[-3.0 to −5.9] improved 6MWD (+30.0 m [15.7 to 44.2], p<0.001), RHI +0.34 (0.03 to 0.63) p=0.03, and AIx75 −7.61% [-14.3 to −0.95], p=0.026.ConclusionsIn people with COPD, prolonged dietary nitrate supplementation in the form of beetroot juice produces a sustained reduction in BP, associated with an improvement in endothelial function and exercise capacity.

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[OP.LB03.05] Reducing Arterial Stiffness Independently of Blood Pressure

Cited by 4 publications

References 0 publications

Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes

Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes

Reducing Arterial Stiffness Independently of Blood Pressure

Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC, a randomised controlled trial

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