Oolong tea increases plasma adiponectin levels and low-density lipoprotein particle size in patients with coronary artery disease

Shimada, Kenei; Kawarabayashi, Takahiko; Tanaka, Atsushi; Fukuda, Daiju; Nakamura, Yasuhiro; Yoshiyama, Minoru; Takeuchi, Kazuhide; Sawaki, Tetsuya; Hosoda, Kazuaki; Yoshikawa, Junichi

doi:10.1016/j.diabres.2004.01.003

Cited by 73 publications

(56 citation statements)

References 30 publications

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“…The release of various inflammatory mediators further promote the proliferation of glomerular mesangial cells, increase endothelial cell permeability, stimulate the production of white blood cells, and promote the release of superoxide and proteolytic enzymes (34,35). These changes further deteriorate renal function and aggravate the elevation of PTH (36).…”

Section: % CI ------------------------------Variablementioning

confidence: 99%

Risk factors associated with secondary hyperparathyroidism in patients with chronic kidney disease

Wei

Lin

Yang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Secondary hyperparathyroidism (SHPT) is common in patients with chronic kidney disease (CKD), and its development and progression are affected by various factors. The aim of the present study was to identify the risk factors for SHPT in patients with CKD. A retrospective study was performed in 498 patients (305 males and 193 females) with CKD, observed in the The First Hospital of Jilin University between January 2008 and December 2012. The demographic, clinical and laboratory data were collected. Patients were divided into the SHPT group (n=424) with elevated serum parathyroid hormone (PTH) expression levels and the control group (n=74) with normal serum PTH expression levels. Univariate and multivariate regression analyses were employed to explore the risk factors for SHPT. Serum PTH expression levels in women with CKD were significantly higher than in men (P= 0.047). Serum PTH expression levels were positively correlated with the expression levels of serum creatinine (P<0.01), phosphorus (P<0.01), C-reactive protein (P<0.05), triglyceride (P<0.05), cholesterol (P<0.05) and low-density lipoprotein cholesterol (P<0.05), but were negatively correlated with the expression levels of hemoglobin (P<0.05), calcium (P<0.01) and CO 2 combining power (P<0.01) in patients with CKD. Multivariate analysis showed that the serum expression levels of creatinine [µmol/l; odds radio (OR), 1.003; 95% confidence interval (CI), 1.002-1.004; P=0.001] and phosphorus (mmol/l; OR, 2.19; 95% CI, 1.254-3.826; P=0.006) in patients with CKD significantly influenced serum PTH expression levels. The SHPT risk factors include female gender, low calcium, high phosphorus, acidosis, anemia, hypertension, hyperlipidemia and micro-inflammation, with blood phosphorus and creatinine being independent risk factors. IntroductionThe incidence of chronic kidney disease (CKD) is rapidly increasing, posing a serious health problem worldwide. More than 16 million adults are affected by end stage CKD in the USA (1,2). Abnormal serum calcium, phosphorus and parathyroid hormone (PTH) expression levels are common challenges in the management of CKD (3,4). These biochemical abnormalities, together with the dysregulation of vitamin D metabolism and bone turnover, constitute a systemic syndrome termed CKD mineral and bone disorder (CKD-MBD) (5).Secondary hyperparathyroidism (SHPT) is a common complication of patients with CKD, which is characterized by increased blood PTH levels, and abnormal mineral and bone metabolism (6). It is associated with increased morbidity and mortality, and adversely influences the quality of life of patients with CKD (3,6). The incidence of SHPT is reported to increase with the stage of CKD: 40% in stage 3, 70% in stage 4 and >80% in stage 5 (4,7).The kidneys are vital organs regulating calcium and phosphorous homeostasis (8). SHPT is an adaptive pathophysiological process in response to deteriorating renal insufficiency (6). The fundamental mechanism of PTH in kidneys is to suppress the reabsorption of phosphate in the pro...

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Section: % CI ------------------------------Variablementioning

confidence: 99%

Risk factors associated with secondary hyperparathyroidism in patients with chronic kidney disease

Wei

Lin

Yang

et al. 2016

Experimental and Therapeutic Medicine

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“…In a human study, Shimada et al found that intake of Oolong tea (EGCG content, 45.4 mg/d) for 4 weeks increased plasma adiponectin levels and decreased plasma total cholesterol in Japanese patients with coronary artery disease. 19) Combining this report with our result, it is most likely that EGCG intake improves lipid homeostasis by enhancing plasma adiponectin levels in insulin secretion-impaired non-obese animal models, and in non-obese type 2 diabetic patients as well. It is still unknown whether the elevation of plasma adiponectin levels under EGCG supplementation is involved in the reduction of plasma triacylglycerol levels.…”

Section: -7)mentioning

confidence: 49%

Dietary Supplementation with Epigallocatechin Gallate Elevates Levels of Circulating Adiponectin in Non-Obese Type-2 Diabetic Goto-Kakizaki Rats

Shimada

Mochizuki

Sakurai

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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Epigallocatechin gallate (EGCG) reportedly enhances plasma adiponectin levels in models of insulin resistance and obesity. In this study, we found that EGCG increases plasma adiponectin levels and decreases plasma triacylglycerol levels in non-obese diabetic Goto-Kakizaki rats with insulin secretory dysfunction. These results suggest that EGCG ameliorates lipid metabolic abnormality even in non-obese rats, probably by increasing adiponectin production.

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“…Oolong tea is a traditional Chinese tea and has recently been reported to have physiological functions such effects on atherogenic, 4) cancer, 5) obesity 6) and antioxidant actions. 7) We paid attention in this study to melanogenesis as one of the new physiological functions of oolong tea and investigated the effects of oolong tea on melanogenesis by using mushroom tyrosinase in a cell-free system, cultured B16 melanoma cells and guinea pigs irradiated by UVB in vivo.…”

Section: Discussionmentioning

confidence: 99%

“…2) Oolong tea is a traditional Chinese tea and known to contain oolong tea-specific polyphenols (oolong tea polymerized polyphenols, OTPP) which are generated in a partially fermented process and are not contained in green tea and black tea. 3) Various studies about the physiological function of oolong tea have shown its effects on atherogenic, 4) cancer, 5) obesity 6) and antioxidant actions. 7) However, the physiological functions of oolong tea on melanogenesis have remained unknown.…”

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confidence: 99%

Melanogenesis Inhibition by an Oolong Tea Extract in B16 Mouse Melanoma Cells and UV-Induced Skin Pigmentation in Brownish Guinea Pigs

Aoki

Tanigawa

Abe

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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Oolong tea increases plasma adiponectin levels and low-density lipoprotein particle size in patients with coronary artery disease

Cited by 73 publications

References 30 publications

Risk factors associated with secondary hyperparathyroidism in patients with chronic kidney disease

Risk factors associated with secondary hyperparathyroidism in patients with chronic kidney disease

Dietary Supplementation with Epigallocatechin Gallate Elevates Levels of Circulating Adiponectin in Non-Obese Type-2 Diabetic Goto-Kakizaki Rats

Melanogenesis Inhibition by an Oolong Tea Extract in B16 Mouse Melanoma Cells and UV-Induced Skin Pigmentation in Brownish Guinea Pigs

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