Dietary Supplementation with Epigallocatechin Gallate Elevates Levels of Circulating Adiponectin in Non-Obese Type-2 Diabetic Goto-Kakizaki Rats

Shimada, Morimi; Mochizuki, Kazuki; Sakurai, Naoko; Goda, Toshinao

doi:10.1271/bbb.70174

Cited by 30 publications

(13 citation statements)

References 24 publications

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“…EGCG has a protective action against several deleterious effects of diseases by minimizing OS (Katiyar et al, 2001;Tipoe et al, 2010;Yao et al, 2008). Dietary supplementation with EGCG was suggested to potentially contribute to T2DM prevention and treatment (Shimada et al, 2007;Wolfram et al, 2006). Results from this study prove that WTEA is rich in EGCG.…”

Section: Discussionmentioning

confidence: 54%

White tea consumption restores sperm quality in prediabetic rats preventing testicular oxidative damage

Oliveira

Tomás

Dias

et al. 2015

Reproductive BioMedicine Online

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Section: Discussionmentioning

confidence: 54%

White tea consumption restores sperm quality in prediabetic rats preventing testicular oxidative damage

Oliveira

Tomás

Dias

et al. 2015

Reproductive BioMedicine Online

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“…Based on these data, adiponectin was conceived to be a novel therapy target for obese and insulin resistance [21]. Elevation of adiponectin level by EGCG was documented in non-obese spontaneous diabetic rats and spontaneous hypertension rats [22], [23]. Based on the above research, we hypothesized that GTPs might regulate the adiponectin levels in HF fed rats, through which GTPs exert their preventive effects on obesity and related diseases.…”

Section: Introductionmentioning

confidence: 99%

Green Tea Polyphenols Reduced Fat Deposits in High Fat-Fed Rats via erk1/2-PPARγ-Adiponectin Pathway

Tian

Zhang

et al. 2013

PLoS ONE

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ObjectiveHypoadiponectinemia contributes to the development of obesity and related disorders such as diabetes, hyperlipidemia, and cardiovascular diseases. In this study we investigated the effects of green tea polyphenols (GTPs) on adiponectin levels and fat deposits in high fat (HF) fed rats, the mechanism of signaling pathway was explored as well.Methods and ResultsMale Wistar rats were fed with high-fat diet. GTPs (0.8, 1.6, 3.2 g/L) were administered via drinking water. Serum adiponectin and insulin were measured by ELISA, mRNA levels of adiponectin and PPARγ in visceral adipose tissue (VAT) were determined by Real-time PCR, protein levels of PPARγ, phospho (p) - PPARγ, extracellular signal regulated kinase (erk) 1/2 and p-erk1/2 in VAT were determined by western blot. GTPs treatment attenuated the VAT accumulation, hypoadiponectinemia and the decreased mRNA level of adiponectin in VAT induced by HF. Decreased expression and increased phosphorylation of PPARγ (the master regulator of adiponectin), and increased activation of erk1/2 were observed in HF group, and these effects could be alleviated by GTPs treatment. To explore the underlying mechanism, VAT was cultured in DMEM with high glucose to mimic the hyperglycemia condition in vitro. Similar to the results of in vivo study, decreased adiponectin levels, decreased expression and increased phosphorylation of PPARγ, and elevated erk1/2 phosphorylation in cultured VAT were observed. These effects could be ameliorated by co-treatment with GTPs or PD98059 (a selective inhibitor of erk1/2).ConclusionGTPs reduced fat deposit, ameliorated hypoadiponectinemia in HF-fed rats, and relieved high glucose-induced adiponectin decrease in VAT in vitro. The signaling pathway analysis indicated that PPARγ regulation mediated via erk1/2 pathway was involved.

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“…It is well known that certain �avonoids exhibit hypoglycemic activity and pancreas beta cell regeneration ability. us the signi�cant anti-diabetic effect of BME and LME may be due to the presence of more than one antihyperglycemic principle and their synergic properties [40,41]. It was also observed that among the extracts tested the methanolic extract of the bark and leaves was the most effective.…”

Section: Discussionmentioning

confidence: 95%

Comparative Evaluation of the Antidiabetic Effects of Different Parts of Cassia fistula Linn, a Southeast Asian Plant

Einstein

Rais

Mohd

2012

Journal of Chemistry

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The hypoglycemic effect of the methanolic and aqueous extracts of whole parts ofCassia fistulain both normoglycemic and streptozotocin-nictotinamide induced Type 2 diabetic rats were investigated. Acute toxicity, oral glucose tolerance test and glucose uptake in isolated rat hemidiaphragm were performed in normal rats. Diabetes was induced in Sprague Dawley rats by the administration of streptozotocin-nictotinamide (50, 110 mg/kg b.w., resp.) intraperitoneally. Different extracts ofCassiawas administered to diabetic rats at 250 and 500 mg/kg doses for 21 days. Biochemical parameters like blood glucose, insulin, glycosylated hemoglobin, lipid profile, and serum marker enzymes were determined. The methanolic extract of the bark and leaves were show more effective in causing hypoglycemia in normoglycemic rats. Diabetic rats showed increased levels of glycosylated hemoglobin, reduced levels of plasma insulin, were significantly reverted to near normal after oral administration of the bark and leaf methanolic extracts. Glucose uptake studies in isolated rat hemidiaphragm have shown enhanced peripheral utilization of glucose. Chronic treatment ofCassiaremarkably restored the normal status of the histopathological changes observed in the selected tissues. Dose dependent anti-diabetic effects with the cohorts receiving the methanolic extract of bark followed by leaves ofCassiawas revealed.

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Dietary Supplementation with Epigallocatechin Gallate Elevates Levels of Circulating Adiponectin in Non-Obese Type-2 Diabetic Goto-Kakizaki Rats

Cited by 30 publications

References 24 publications

White tea consumption restores sperm quality in prediabetic rats preventing testicular oxidative damage

White tea consumption restores sperm quality in prediabetic rats preventing testicular oxidative damage

Green Tea Polyphenols Reduced Fat Deposits in High Fat-Fed Rats via erk1/2-PPARγ-Adiponectin Pathway

Comparative Evaluation of the Antidiabetic Effects of Different Parts of Cassia fistula Linn, a Southeast Asian Plant

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