Comparative Evaluation of the Antidiabetic Effects of Different Parts of <i>Cassia fistula</i> Linn, a Southeast Asian Plant

Einstein, John Wilking; Rais, Mustafa Mohd; Mohd, Mustafa Ali

doi:10.1155/2013/714063

Cited by 15 publications

(8 citation statements)

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“…In addition to this, the extract may cause inhibition of glucose absorption in the gut. 35,38,39,54 Daisy et al, (2010) reported that catechin isolated from methanolic extract of C. fistula bark has significant hypoglycemic and insulin mimetic effect in STZ-induced diabetic rats. 35 Previous studies conclusively have shown that phytochemicals like, proanthrocynadins, 55 kaempferol, 56 quercetin 57,58 and anthroqunone derivatives 59,60 possess hypoglycemic effects in the diabetic animals.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antidiabetic Activity of Hydroalcoholic Extract of Cassia fistula Linn. pod in Streptozotocin-Induced Diabetic Rats

Jangir¹,

Jain²

2017

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Background: Diabetes mellitus (DM) is a global health problem and the incidence of DM is increasing at alarming rate all over the world. Many Indian medicinal plants have been reported to possess potential antidiabetic activity and could play important role in the management diabetes. Objective: The present study aimed to evaluate antidiabetic activities of 70% ethanolic extract of Cassia fistula pod in streptozotocin-induced diabetic rats. Materials and Methods: Diabetes was induced in male Wistar rats by single intraperitoneal injection of streptozotocin (60 mg/kg b.wt.). The diabetic rats were administered orally with C. fistula pod extract at three different doses (100, 250 and 500 mg/kg b.wt./day) for 60 days. The results were compared with standard drug glibenclamide (5 mg/kg b.wt./day) treated rats. Results: The streptozotocin treated diabetic control rats showed a significant increase in the blood glucose and glycosylated hemoglobin (HbA1c) levels with a concomitant decrease in the body weight and glycogen content in the liver as compared to normal control rats. Oral administration of C. fistula pod extract (100, 250 and 500 mg/kg b.wt./day) or glibenclamide for 60 days showed significant reduction in the blood glucose and HbA1c levels and an elevation in the body weight and hepatic glycogen content as compared to diabetic control rats. Furthermore, treatment with extract (500 mg/kg b.wt.) also showed improvement of oral glucose tolerance test (OGTT) in diabetic rats. These results were comparable to glibenclamide. Conclusion:The results of present study showed that C. fistula pod extract possess significant antihyperglycemic activity and supports the traditional use of C. fistula pod for the treatment of diabetes mellitus. Key words: Antidiabetic, Blood glucose, Cassia fistula, Glycogen, Glycosylated hemoglobin, Streptozotocin. Cite this article : Jangir RN, Jain GC. Evaluation of antidiabetic activity of hydroalcoholic extract of Cassia fistula Linn. pod in streptozotocin-induced diabetic rats. Pharmacog J. 2017;9(5):599-606. Ram Niwasphytochemicals. Many Indian medicinal plants have been found to be useful in the management of diabetes acting though variety of mechanisms. Medicinal plants provide better alternatives as they are less toxic, easily available and affordable and many of the currently available drugs have been derived directly or indirectly from them. 6,7 Cassia fistula Linn. (Hindi-Amaltas; EnglishGolden Shower or Indian Laburnum), a medium sized tree belonging to the family-Caesalpiniaceae, is cultivated throughout India as an ornamental plant and is used widely for its medicinal properties. Almost every part of C. fistula are used extensively in the folklore medicine for the treatment of a variety of diseases. 8,9 The dried pod and pulp are valued for their laxative properties. The pulp is considered a safe purgative, recommended for pregnant women and children to relieve disorders of the liver and biliousness. It is a remedy for malaria and black water fever. It is also used to...

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Section: Discussionmentioning

confidence: 99%

Evaluation of Antidiabetic Activity of Hydroalcoholic Extract of Cassia fistula Linn. pod in Streptozotocin-Induced Diabetic Rats

Jangir¹,

Jain²

2017

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“…Concurrent histopathology studies of the pancreas also demonstrated the comparable regeneration of pancreatic β-cells by the aqueous extract, which was earlier necrosed by alloxan, directed that the extract might be of potential value for diabetes management. Einstein, Mohd Rais, and Mohd (2012) reported that the methanol extract of leaves and bark of C. fistula started promoting the antihyperglycemic effect in streptozotocininduced diabetic rats from the seventh day and attaining the maximum beneficial potential on 21st day of administration. In diabetic rats, the elevated blood glucose levels, increased glycosylated hemoglobin levels, and reduced plasma insulin levels were significantly resumed to normal after the oral administration of methanol extract of leaves and bark at the dose of 500 mg/kg.…”

Section: Antiasthmatic Activitymentioning

confidence: 99%

The genusCassiaL.: Ethnopharmacological and phytochemical overview

Khurm

Wang

Zhang

et al. 2020

Phytotherapy Research

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after first online publication: The funding information and acknowledgement sections have been updated in this version.] Nature gifts medicinal plants with the untapped and boundless treasure of active chemical constituents with significant therapeutic potential that makes these plants a beneficial source in the development of phytomedicines. Genus Cassia, with approximately 500 species, is a large group of flowering plants in the family Fabaceae. Cassia species are widely distributed throughout different regions mainly tropical Asia, North America, and East Africa. In the folk medicinal history, these plants are used as laxative and purgative agents. In the Ayurveda system of medicine, they are used to cure headache and fever. Cassia plants exhibit pharmacological activities at large scales such as antimicrobial, anticancer, antiinflammatory, antioxidant, hypoglycemic, hyperglycemic, antimutagenic, and antivirals. The phytochemical investigations of genus Cassia demonstrate the presence of more than 200 chemical compounds, including piperidine alkaloids, anthracene derivatives (anthraquinones), flavonoids, pentacyclic triterpenoids, sterols, phenylpropanoids, and γ-naphthopyrones. The literature illustrated anthraquinones and flavonoids as major secondary metabolites from this genus. However, some Cassia plants, with rich contents of anthraquinones, still show toxicology properties. As Cassia plants are used extensively in the herbal Abbreviations: AAE, ascorbic acid equivalent; AGEs, advanced glycation end products; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CAT, catalase enzyme; CCl4, carbon tetrachloride; CFU, colony forming units; COLO320DM, human colon carcinoma cell line; CRFK, crandell feline kidney cell; DMSO, dimethyl sulfoxide; DPPH, 2,2-diphenyl-1-picrylhydrazyl; EC 50 , half maximal effective concentration; ELISA, enzyme-linked immunosorbent assay; FDA, Food and Drug Administration; GPx, glutathione peroxidase; HCT-116, human colorectal carcinoma cell line; HDL, high-density lipoprotein; HeLa, immortal cell line used in scientific research; HEL, human erythroleukemia cell line; Hep-2, human epithelial type 2 cells; HIV,

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“…[93] Methanolic and aqueous extracts of whole parts of C. fistula exhibit hypoglycemic effect both in normoglycemic and streptozotocin-nicotinamide induced Type 2 diabetic rats. [94] Anticonvulsant Cassia siamea contains barakol a potential anxiolytic agent [95] that causes lowering of intraocular pressure in a DBA/2J mouse glaucoma model. [96] Cassia species are also used for treating epilepsy by indigenous communities of sub-Himalayan region of Uttarakhand [ Table 1].…”

Section: Antidiarrheamentioning

confidence: 99%

Untitled

Upadhyay¹

2020

IJGP

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The present review article emphasized the pharmaceutical, insecticidal, and therapeutic role of Cassia fistula and its associating species. This is an ornamental plant grown in all parts of India and has a long traditional use in Ayurvedic medicines for the treatment of cough, cold, and sneezing. Plant is a good depository of chemical constituents which display wide array of biological activities such as antipyretic, analgesics, antiseptic, anticancer, antidiabetic, anti-inflammatory, anti-arthritic, antiparasitic, antitumor, antioxidant, chemopreventive, and hepatoprotective. Plant contains important nutraceuticals such as protein 12%, carbohydrate 11.75%, lipid 12%, and free amino acid 1.42%, respectively. C. fistula contains quality antioxidants which provide relieve in ulcers, jaundice, and piles, treat migraine and blood dysentery, treat fever, and relieve from chest and joint pain. The fruit of C. fistula is a good source of Fe and Mn, it is used in treatment of eczema cough, throat troubles, gastric, and liver complaints. Root extract shows tonic, astringent, febrifuge, and strong purgative activities. Plant is also a good source of nutrients, essential oils, antioxidants, and diverse phytochemicals which could be used for production of herbal drugs for the treatment of various diseases.

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Comparative Evaluation of the Antidiabetic Effects of Different Parts of Cassia fistula Linn, a Southeast Asian Plant

Cited by 15 publications

References 28 publications

Evaluation of Antidiabetic Activity of Hydroalcoholic Extract of Cassia fistula Linn. pod in Streptozotocin-Induced Diabetic Rats

Evaluation of Antidiabetic Activity of Hydroalcoholic Extract of Cassia fistula Linn. pod in Streptozotocin-Induced Diabetic Rats

The genusCassiaL.: Ethnopharmacological and phytochemical overview

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