“…Epidemiological studies demonstrate Ushaped ( Fig. 1) or J-shaped frequency curves related to the age of the mother for monozygotic twins (16,49), hydatidiform mole (46), spontaneous abortion (5,56,65), pre-eclamptic toxemia (9, 10), single umbilical artery (3), abruptio placentae (47), intra-uterine growth retardation (11,48,60), perinatal mortality (15,53,71), stillbirths and congenital anomalies (6,7,25,64,65), and intellectual impairment of children (41). A same U, or at least a J-shaped, curve may be presumed in patients with gonosomal as well as autosomal chromosome aberrations.…”