Epidemiological Characteristics of Twinning Rates in Taiwan

Chen, Chiou-Jong; Lin, Tsung‐Hsien; Chang, Chiao-Erh; Cheng, Yawen

doi:10.1017/s0001566000006085

Cited by 36 publications

(31 citation statements)

References 26 publications

(44 reference statements)

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“…4 In urban populations of countries where assisted fertilization is not widespread, a decline in dizygotic twinning has been observed that was positively correlated with parity, independent of age. [5][6][7][8][9][10][11] With regard to the monozygotic twinning rate, most populations have shown stability of its incidence, but a few authors have observed a slight increase in monozygotic twin births. 1,2,[10][11][12][13] The rise in monozygotic twinning might be explained as a consequence of residual effects of long term use of oral contraceptives.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, another cause influencing the increase in multiple births in these hospitals is maternal age, which is correlated with twinning, due to an increase of dizygotic pairs. [5][6][7][8][9][10][11] This paper had the objective of estimating the frequency of multiple births in a first-class tertiary private hospital in Brazil.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8][9][10][11] Women attended to in the Hospital Israelita Albert Einstein are older (mothers of singletons = 31.12 years ± 4.60; mothers of twins = 31.93 years ± 4.49) than those of the general population of southeastern Brazil (mothers of singletons = 24.98 years ± 5.99; mothers of twins = 26.82 ± 6.02). 20 However, age cannot be considered the only cause of this increase either, since according to Table 2 the mean twinning rate was also high among newborns of primigravidae younger than 30 years (18.03 per 1,000), with the proportion of dizygotic pairs still being high (14.17 per 1,000) or about 79% of the twin births.…”

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confidence: 99%

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Twinning rate in a sample from a Brazilian hospital with a high standard of reproductive care

Colletto

Beiguelman

2001

Sao Paulo Med. J.

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CONTEXT: Epidemiological studies on twin births have been motivated mostly by the positive correlation between twinning rate and human fertility, prematurity, low birth weight, increased risk of infant death and long term risk for morbidity. OBJECTIVE: This paper intends to estimate the incidence of multiple births in a private hospital in Brazil with a high standard of reproductive care, and to evaluate the effects of maternal age, gestation order and assisted fertilization on twinning rate. DESIGN: Retrospective analysis. SETTING: First-class tertiary private hospital, São Paulo, Brazil. PARTICIPANTS: The multiple birth rate was investigated among 7,997 deliveries from 1995 to 1998, including 7,786 singletons, 193 twins, 17 triplets and one quadruplet. RESULTS: The rates per 1,000 dizygotic and monozygotic pairs and for triplets were estimated as 19.51, 4.50 and 2.13, respectively. The dizygotic and triplet rates were the highest observed in Brazil up to the present day. The twinning rate among primigravidae older than 30 years was very high (45.02 per 1,000) and was due to a disproportionately high frequency of dizygotic pairs. The triplet rate was also very high among the mothers of this age group (5.71 per 1,000). These facts are strong indicators that these women were the ones most frequently submitted to assisted reproductive techniques. The mean maternal age of the studied population was about six years higher than that estimated for mothers in the general population of southeastern Brazil. Primigravidae aged under 30 years as well as multigravidae showed similar twinning rates, which were almost 20 per 1,000. Among the deliveries of multigravidae older than 30 years, an unusually high frequency of monozygotic twins was observed (7.04 per 1,000), probably as a consequence of the residual effect of long-term use of oral contraceptives. CONCLUSIONS: The dizygotic twinning rate increased from 13.51 to 28.98 per 1,000 over the four years studied, with the twinning rate for primigravidae over 30 years old in 1998 being twice that observed in 1995. The mean maternal age was also high during this period, but the extremely high increase in twinning rate observed cannot be attributed solely to this variable. Assisted fertilization seems to be the most probable cause of this unusually high twinning rate.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Twinning rate in a sample from a Brazilian hospital with a high standard of reproductive care

Colletto

Beiguelman

2001

Sao Paulo Med. J.

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“…Both maternal age and parity affected the twinning rates in both populations; however, the effects were not additive without interaction between maternal age and parity (Picard et al, 1989). In Canada (Elwood, 1978) and Taiwan (Chen et al, 1987) increased twinning was noted with both maternal age and with the number of previous livebirths. In one study the higher the maternal age, the lower the twinning rates were, while the higher the parity, the higher the rates (Chen et al, 1992).…”

Section: Figurementioning

confidence: 89%

Twinning and Birth Weight in the Israeli Jewish Versus Muslim Maternities

Goldman¹,

Mazkereth

Blickstein

2002

Twin Research

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“…The relatively low participation rate was probably owing to the time-consuming nature of the oral glucose tolerance test, which lasts 120 minutes with an indwelling venous line. As monozygotic (MZ) twins are more common than dizygotic (DZ) twins in Taiwan (Chen et al, 1987), sibling pair families (n = 56; age variation within 2 years) from seven schools were also recruited to complement the number of DZ twins (Chen et al, 1999). In this study, all twins and sibling pairs were born and reared together in the same household.…”

Section: Recruitment Processmentioning

confidence: 99%

The Taipei Adolescent Twin/Sibling Family Study II: Depression, Insulin Resistance, and Hormonal Factors

Kuo¹,

Liu

Chuang

et al. 2006

twin res hum genet

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I n this ongoing longitudinal study of adolescent twins/sibling pairs and their parents in Taipei, we aimed to investigate the genetic and environmental influences on adolescent behavioral development, metabolic risk factors, and the associations between the two. Special focus is on anxious depression, metabolic profile, and hormonal factors such as cortisol and leptin. The first wave of assessment was completed during the period of 2002 to 2005 and included 192 twin pairs, 6 triplets, 56 sibling pairs and their first-degree relatives (484 parents and 142 siblings). We are currently in the process of a second wave assessment as follow-up. Dimensional psychological assessments using self-report questionnaires, as well as categorical assessments based on semistructured clinical interviews, were performed. All subjects received a 2-hour oral glucose tolerance test at the examination site. The metabolic phenotypes including body mass index, blood pressure, levels of glucose, insulin, and lipid profile as well as related hormonal levels were measured. Zygosity was determined using DNA, except for a few twins whose DNA was not available. Such a combination of detailed psychological assessments and metabolic function tests is expected to help shed light on the interrelation of psychological well-being and metabolic functioning.A growing body of literature suggests that metabolic risk factors and anxious depression are closely interrelated. Differences in metabolic function indexes such as body mass index (BMI), levels of glucose, triglyceride, cholesterol, as well as blood pressure were observed in individuals with anxiety, depression, or both, in comparison to controls (Golden et al., 2004;McCaffery et al., 2003;Raikkonen et al., 2002). Intriguingly, these metabolic risk factors also tend to be clustered in adolescents (Cook et al., 2003;Weiss et al., 2004). Similarly, patients with major depression exhibited insulin resistance during an oral glucose tolerance test compared to controls (Winokur et al., 1988). A recent review concluded the existence of an association between depression and type 2 diabetes (Musselman et al., 2003). Furthermore, it has been shown that several hormones such as cortisol, an index of hypothalamic-pituitary-adrenal (HPA) axis activity and leptin, an adiposity hormone involved in food intake and weight regulation, have been involved in the regulation of mood and metabolic function (Atmaca et al., 2005;Bjorntorp, 2001;Kraus et al., 2001;Liuzzi et al., 1999;Livshits et al., 2005). Despite the consistent overlap between these two traits, few studies have adopted an integrative strategy that includes both psychological and physiological assessments to elucidate the etiology of anxiety/depression and metabolic functions.Recognizing the need for integrating psychological and physiological information, we initiated a longitudinal, multivariate study of adolescent twins/sibling pairs aged 12 to 18 years, and their siblings and parents as well, in an attempt to investigate how psychological factors co...

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Epidemiological Characteristics of Twinning Rates in Taiwan

Cited by 36 publications

References 26 publications

Twinning rate in a sample from a Brazilian hospital with a high standard of reproductive care

Twinning rate in a sample from a Brazilian hospital with a high standard of reproductive care

Twinning and Birth Weight in the Israeli Jewish Versus Muslim Maternities

The Taipei Adolescent Twin/Sibling Family Study II: Depression, Insulin Resistance, and Hormonal Factors

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