Oocyte Morphology and Reproductive Outcomes - Case Report and Literature Review

Guimarães, Raquel Meirelles Gaspar Coelho; Ribeiro, Larissa Maciel; Sasaki, Lizandra Moura Paravidine; Nakagawa, Hitomi; Cabral, I.O

doi:10.5935/1518-0557.20210001

Cited by 1 publication

(1 citation statement)

References 25 publications

(91 reference statements)

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“…The reason is that with the increase of maternal age, the formation of ovarian germ cells decreases, the quality of oocytes decreases, and eventually leads to ovarian reproductive failure. 21 Some studies have suggested that decreased fecundity and fertilization rates in elderly women are also associated with decreased follicle reserve 22 and increased aneuploidy. 23 , 24 The proportion of fetuses born to women aged ≥35 years old with chromosomal abnormalities is significantly increased, as is the probability of spontaneous abortion.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Pregnancy Failure in Infertile Patients Undergoing Assisted Reproductive Technology

Yang

Tang

et al. 2022

IJGM

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Background Infertile couples need to use assisted reproductive technology (ART) to give birth. However, pregnancy failure after ART is not uncommon. At present, the results of studies on the causes of pregnancy failure after ART are inconsistent. Methods A retrospective cohort study involving 715 embryo transfer cycles was conducted at the Reproductive Medicine Center of Meizhou People’s Hospital, from December 2015 to June 2022. According to the pregnancy, they were divided into clinical pregnancy group and pregnancy failure group. The relationship between demographic characteristics and pregnancy status between the two groups was analyzed. Results The pregnancy failure rate after ART was 49.7% (355/715). There were statistically significant distribution differences of maternal age, paternal age, COH protocols, and number of embryos transferred between clinical pregnancy and pregnancy failure groups (all P<0.01). Multiple logistic regression analysis shows that high maternal age (>35 years old vs ≤35 years old: OR 2.173, 95% CI: 1.386–3.407, P=0.001), and GnRH-a short protocol (GnRH-a short protocol vs GnRH-a long protocol: OR 2.139, 95% CI: 1.127–4.058, P=0.020) may increase risk of pregnancy failure in ART pregnancies, while two embryos transferred (two embryos transferred vs one embryo transferred: OR 0.563, 95% CI: 0.377–0.839, P=0.005) may reduce risk of pregnancy failure. In addition, high maternal age, GnRH antagonist protocol, and GnRH-a short protocol may increase risk of implantation failure, while two embryos transferred may reduce risk of implantation failure. And high maternal age may increase risk of biochemical pregnancy. Conclusion The risk of pregnancy failure increased in ART cycles with maternal age >35 years old and GnRH-a short protocol, while reduced with two embryos transferred.

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