Oocyte maturation abnormalities - A systematic review of the evidence and mechanisms in a rare but difficult to manage fertility pheneomina

Hatırnaz, Şafak; Hatırnaz, Ebru; Kaya, Aşkı Ellibeş; Hatırnaz, Kaan; Çalışkan, Canan Soyer; Sezer, Özlem; Güngör, Nur Dokuzeylül; Demirel, Cem; Baltacı, Volkan; Tan, Seang Lin; Dahan, Michael H.

doi:10.4274/tjod.galenos.2022.76329

Cited by 5 publications

(6 citation statements)

References 221 publications

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“…In most vertebrates, oocytes primarily arrested in prophase of meiosis I, resume meiosis and undergo germinal vesicle breakdown to produce mature oocytes that arrest at metaphase of the second meiotic division until fertilization (Von Stetina & Orr-Weaver, 2011;Nader et al, 2013). Meiotic arrest and resumption are controlled by specific molecular events (Machaca, 2007;Santella et al, 2020;Hatirnaz et al, 2022;Mostafa et al, 2022), and are driven by a complex cascade of hormonal signaling (Abbara et al, 2018;Stewart & Davis, 2019). Despite the complexity and diversity of these molecular and physiological events, they converge on Ca 2+ as a key orchestrator of these developmental events (Figure 1).…”

Section: Neuronal Signaling and Calcium Regulation During Oocyte Matu...mentioning

confidence: 99%

Neurotransmitters, neuropeptides and calcium in oocyte maturation and early development

Alhajeri

Alkhanjari

Hodeify

et al. 2022

Front. Cell Dev. Biol.

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A primary reason behind the high level of complexity we embody as multicellular organisms is a highly complex intracellular and intercellular communication system. As a result, the activities of multiple cell types and tissues can be modulated resulting in a specific physiological function. One of the key players in this communication process is extracellular signaling molecules that can act in autocrine, paracrine, and endocrine fashion to regulate distinct physiological responses. Neurotransmitters and neuropeptides are signaling molecules that renders long-range communication possible. In normal conditions, neurotransmitters are involved in normal responses such as development and normal physiological aspects; however, the dysregulation of neurotransmitters mediated signaling has been associated with several pathologies such as neurodegenerative, neurological, psychiatric disorders, and other pathologies. One of the interesting topics that is not yet fully explored is the connection between neuronal signaling and physiological changes during oocyte maturation and fertilization. Knowing the importance of Ca2+ signaling in these reproductive processes, our objective in this review is to highlight the link between the neuronal signals and the intracellular changes in calcium during oocyte maturation and embryogenesis. Calcium (Ca2+) is a ubiquitous intracellular mediator involved in various cellular functions such as releasing neurotransmitters from neurons, contraction of muscle cells, fertilization, and cell differentiation and morphogenesis. The multiple roles played by this ion in mediating signals can be primarily explained by its spatiotemporal dynamics that are kept tightly checked by mechanisms that control its entry through plasma membrane and its storage on intracellular stores. Given the large electrochemical gradient of the ion across the plasma membrane and intracellular stores, signals that can modulate Ca2+ entry channels or Ca2+ receptors in the stores will cause Ca2+ to be elevated in the cytosol and consequently activating downstream Ca2+-responsive proteins resulting in specific cellular responses. This review aims to provide an overview of the reported neurotransmitters and neuropeptides that participate in early stages of development and their association with Ca2+ signaling.

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Section: Neuronal Signaling and Calcium Regulation During Oocyte Matu...mentioning

confidence: 99%

Neurotransmitters, neuropeptides and calcium in oocyte maturation and early development

Alhajeri

Alkhanjari

Hodeify

et al. 2022

Front. Cell Dev. Biol.

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“…Meiotic resumption begins with the germinal vesicle breakdown (GVBD) and is followed by metaphase I and subsequently metaphase II. Oocyte maturation and competence are coordinated during meiotic resumption and maturation [ 3 ]. Until the evaluation of the retrieved oocytes from in-vitro fertilization (IVF) cycles, in most cases, no one can determine if oocyte-specific factors are present in patients with infertility.…”

Section: Introductionmentioning

confidence: 99%

“…Until the evaluation of the retrieved oocytes from in-vitro fertilization (IVF) cycles, in most cases, no one can determine if oocyte-specific factors are present in patients with infertility. To diagnose oocyte maturation abnormalities (OMAS), the required laboratory findings need to be repeated in at least in two consecutive IVF cycles [ 3 ]. Our ongoing studies have revealed that oocytes of patients with OMAS often demonstrate intracycle and intercycle variabilities, with different levels of arrest occurring in different cycles [ 3 ], for example, MI arrest in one cycle and germinal vesicle arrest (GV) in a different cycle.…”

Section: Introductionmentioning

confidence: 99%

“…To diagnose oocyte maturation abnormalities (OMAS), the required laboratory findings need to be repeated in at least in two consecutive IVF cycles [ 3 ]. Our ongoing studies have revealed that oocytes of patients with OMAS often demonstrate intracycle and intercycle variabilities, with different levels of arrest occurring in different cycles [ 3 ], for example, MI arrest in one cycle and germinal vesicle arrest (GV) in a different cycle. Contrary to the present nomenclature that restricts the diagnosis of OMAS to certain subtypes, it seems that the diagnostic evaluation of OMAS needs to be extended.…”

Section: Introductionmentioning

confidence: 99%

“…These systems are based on excluding other abnormalities [ 4 , 5 , 6 ]. However, our ongoing study on OMAS revealed that there are novel subsets of oocyte maturation arrest and other pathologies such as oocyte degeneration, empty follicle syndrome (EFS), some forms of premature ovarian failure (POF) and resistant ovarian syndrome (ROS) that could be included in the OMAS classification [ 3 ]. Both intrafollicular and extrafollicular factors may cause oocyte pathologies ranging from oocyte degeneration, empty follicles, oocyte maturation arrest and impaired embryonic development [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Unraveling the Puzzle: Oocyte Maturation Abnormalities (OMAS)

Hatırnaz¹,

Hatırnaz²,

Çelik

et al. 2022

Diagnostics

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Oocyte maturation abnormalities (OMAS) are a poorly understood area of reproductive medicine. Much remains to be understood about how OMAS occur. However, current knowledge has provided some insight into the mechanistic and genetic origins of this syndrome. In this study, current classifications of OMAS syndromes are discussed and areas of inadequacy are highlighted. We explain why empty follicle syndrome, dysmorphic oocytes, some types of premature ovarian insufficiency and resistant ovary syndrome can cause OMAS. We discuss live births in different types of OMAS and when subjects can be offered treatment with autologous oocytes. As such, we present this review of the mechanism and understanding of OMAS to better lead the clinician in understanding this difficult-to-treat diagnosis.

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TUBB8 mutations as a cause of oocyte maturation abnormalities: presentation of oocyte and embryo profiles and novel mutations

Ebru,

Dahan,

Sezer

et al. 2023

Reproductive BioMedicine Online

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Oocyte maturation abnormalities - A systematic review of the evidence and mechanisms in a rare but difficult to manage fertility pheneomina

Cited by 5 publications

References 221 publications

Neurotransmitters, neuropeptides and calcium in oocyte maturation and early development

Neurotransmitters, neuropeptides and calcium in oocyte maturation and early development

Unraveling the Puzzle: Oocyte Maturation Abnormalities (OMAS)

TUBB8 mutations as a cause of oocyte maturation abnormalities: presentation of oocyte and embryo profiles and novel mutations

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