Oocyte donation

Klein, J.; Sauer, Mark V.

doi:10.1053/beog.2002.0288

Cited by 39 publications

(24 citation statements)

References 72 publications

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“…Oocyte donation studies show that aging-related infertility in women can be effectively overcome through the use of oocytes from young adult donors (34,35). Additionally, postmenopausal women can carry pregnancies to term as surrogates with success rates equaling those of younger patients undergoing ART with their own oocytes (36,37).…”

Section: Discussionmentioning

confidence: 99%

Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies

Selesniemi

Lee

Muhlhauser

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

174

167

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Increased meiotic spindle abnormalities and aneuploidy in oocytes of women of advanced maternal ages lead to elevated rates of infertility, miscarriage, and trisomic conceptions. Despite the significance of the problem, strategies to sustain oocyte quality with age have remained elusive. Here we report that adult female mice maintained under 40% caloric restriction (CR) did not exhibit aging-related increases in oocyte aneuploidy, chromosomal misalignment on the metaphase plate, meiotic spindle abnormalities, or mitochondrial dysfunction (aggregation, impaired ATP production), all of which occurred in oocytes of age-matched ad libitum-fed controls. The effects of CR on oocyte quality in aging females were reproduced by deletion of the metabolic regulator, peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α). Thus, CR during adulthood or loss of PGC-1α function maintains female germline chromosomal stability and its proper segregation during meiosis, such that ovulated oocytes of aged female mice previously maintained on CR or lacking PGC-1α are comparable to those of young females during prime reproductive life.bioenergetics | fertility | germ cell | oogenesis | ovary

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Section: Discussionmentioning

confidence: 99%

Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies

Selesniemi

Lee

Muhlhauser

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

174

167

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“…There are other potential confounders as well. Although some studies have shown that increased maternal age is not associated with increased reproductive failure among OD recipients (3,4), it would be worth exploring as a potential confounder because of its association with BMI in this study (1). A more subtle potential source of bias is secular time.…”

mentioning

confidence: 85%

Disentangling causal paths between obesity and in vitro fertilization outcomes: an intractable problem?

Howards

Cooney

2008

Fertility and Sterility

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“…However, pregnancies achieved with donated oocytes are associated with a high incidence of first trimester bleeding and a 2-to 3-fold higher risk of gestational hypertension and pre-eclampsia when compared with conventional IVF (Serhal and Craft, 1989;Abdalla et al, 1998;Sö derstrom-Anttila et al, 1998;Yaron et al, 1998;Klein and Sauer, 2002;Sheffer-Mimouni et al, 2002;Wiggins and Main 2005;van der Hoorn et al, 2010;Stoop et al, 2012). The incidences of intrauterine growth restriction, preterm birth (PTB) and birth defects have mostly been comparable with conventional IVF (van der Hoorn et al, 2010), although impaired fetal growth in OD pregnancies when compared with conventional IVF has been noted (Gibbons et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Obstetric and neonatal outcome after oocyte donation in 106 women with Turner syndrome: a Nordic cohort study

et al. 2013

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summary answer: Pregnancies among women with TS carry a substantial risk, particularly for hypertensive disorders. Potentially lifethreatening complications occurred in 3.3% of pregnancies. The neonatal outcomes were generally reassuring, with similar rates of preterm birth and low birthweight (LBW) as after conventional IVF and better than previously reported in deliveries after OD in women with TS.what is known already: OD pregnancies in women with TS are known to be high-risk pregnancies. study design, size, duration: This retrospective cohort study included 106 women with TS who delivered after OD (n ¼ 122 deliveries, n ¼ 131 newborns) in three Nordic countries (Finland, Denmark, Sweden) between 1992 and participants, setting and methods: Women with TS who delivered after OD in three Nordic countries were identified (n ¼ 110). Four women declined to participate or were lost to follow-up, thus 106 women were included in the study. The medical data from fertility clinics, antenatal clinics and the hospitals where the women had been treated and/or delivered were scrutinized.main results and the role of chance: In this cohort, the karyotype was 45,X in 44% of the women with TS. Ten women (9.4%) had a known cardiac defect before pregnancy. Single embryo transfer was performed in 70.3% of the cases and the multiple birth rate was 7.4%. In total, 35.0% of the pregnancies were associated with a hypertensive disorder including pre-eclampsia in 20.5%. Potentially lifethreatening complications occurred in four pregnancies (3.3%), including one woman with aortic dissection, one with mild regurgitation of the tricuspid and mitral valve, one with a mechanical heart valve who developed HELLP syndrome (haemolysis, elevated liver enzymes, low platelets) and one who underwent a post-partum hysterectomy due to severe haemorrhaging. Neonatal outcomes were reassuring, with a preterm birth rate of 8.0% and LBW rate of 8.8% in singletons. Major birth defects were found in 3.8% of the children. The perinatal mortality was 2.3% (3/131), including a set of extremely preterm twins.limitations, reasons for caution: Although this study was performed over a period of almost 20 years in three different countries, with a low drop-out rate and little missing data, much larger series are needed to assess rare events. This study also lacks an appropriate control group. Reproduction, Vol.28, No.6 pp. 1598-1609, 2013 Advanced Access publication on March 27, 2013 doi:10.1093/humrep/det082 Downloaded from https://academic.oup.com/humrep/article-abstract/28/6/1598/605487 by guest on 07 June 2019 wider implications of the findings: This study suggests that cardiovascular evaluation before and during pregnancy may contribute to favourable obstetric outcomes in many cases. Maternal outcomes were in agreement with the literature while neonatal outcomes were generally better than previously reported. The outcomes were consistent across the three countries, supporting generalizability to similar populations.

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Oocyte donation

Cited by 39 publications

References 72 publications

Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies

Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies

Disentangling causal paths between obesity and in vitro fertilization outcomes: an intractable problem?

Obstetric and neonatal outcome after oocyte donation in 106 women with Turner syndrome: a Nordic cohort study

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