OOCDB: A Comprehensive, Systematic, and Real-Time Organs-on-a-Chip Database

Abstract

Organs-on-a-chip is a microfluidic microphysiological system that uses microfluidic technology to analyze the structure and function of living human cells at the tissue and organ levels in vitro. Organs-on-a-chip technology, as opposed to traditional two-dimensional cell culture and animal models, can more closely simulate pathologic and toxicologic interactions between different organs or tissues and reflect the collaborative response of multiple organs to drugs. Despite the fact that many organs-on-a-chip-related data have been published, none of the current databases have all of the following functions: searching, downloading, as well as analyzing data and results from the literature on organs-on-a-chip. Therefore, we created an organs-on-a-chip database (OOCDB) as a platform to integrate information about organs-on-a-chip from various sources, including literature, patents, raw data from microarray and transcriptome sequencing, several open-access datasets of organs-on-a-chip and organoids, and data generated in our laboratory. OOCDB contains dozens of sub-databases and analysis tools, and each sub-database contains various data associated with organs-on-a-chip, with the goal of providing researchers with a comprehensive, systematic, and convenient search engine. Furthermore, it offers a variety of other functions, such as mathematical modeling, three-dimensional modeling, and citation mapping, to meet the needs of researchers and promote the development of organs-on-a-chip. The OOCDB is available at http://www.organchip.cn.

Revolutionizing toxicology: organ-on-a-chip insights in a snapshot

“…By replicating the complex architecture and physiological conditions of human organs, OOC models offer a unique opportunity to bridge the gap between traditional experimental models, enabling more accurate predictions of drug responses and toxicities. 7 As we delve into the insights provided by OOC platforms, it becomes evident that these miniature organ models hold immense promise for advancing our understanding of toxicological mechanisms. By incorporating microfluidic systems, biomaterials, and relevant physiological factors, OOC technology provides a platform where researchers can observe and analyze drug-induced effects with unprecedented precision.…”