Recent advances in 3D-printing-based organ-on-a-chip

Wu, Xinkun; Shi, Wenwan; Liu, Xiaojiang; Gu, Zhongze

doi:10.1016/j.engmed.2024.100003

Cited by 3 publications

(2 citation statements)

References 261 publications

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“…This model provides the scientific community with a cutting-edge tool by combining engineering and biological expertise. Therefore, 3D-printed microfluidic devices can replicate physiological conditions with high precision, offering a powerful tool for drug testing and disease modeling [ 55 ].…”

Section: Light-driven 3d-printed Microfluidics For Tissue Culturementioning

confidence: 99%

Advancing Tissue Culture with Light-Driven 3D-Printed Microfluidic Devices

Li,

Wang,

Davis

et al. 2024

Biosensors

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Three-dimensional (3D) printing presents a compelling alternative for fabricating microfluidic devices, circumventing certain limitations associated with traditional soft lithography methods. Microfluidics play a crucial role in the biomedical sciences, particularly in the creation of tissue spheroids and pharmaceutical research. Among the various 3D printing techniques, light-driven methods such as stereolithography (SLA), digital light processing (DLP), and photopolymer inkjet printing have gained prominence in microfluidics due to their rapid prototyping capabilities, high-resolution printing, and low processing temperatures. This review offers a comprehensive overview of light-driven 3D printing techniques used in the fabrication of advanced microfluidic devices. It explores biomedical applications for 3D-printed microfluidics and provides insights into their potential impact and functionality within the biomedical field. We further summarize three light-driven 3D printing strategies for producing biomedical microfluidic systems: direct construction of microfluidic devices for cell culture, PDMS-based microfluidic devices for tissue engineering, and a modular SLA-printed microfluidic chip to co-culture and monitor cells.

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Section: Light-driven 3d-printed Microfluidics For Tissue Culturementioning

confidence: 99%

Advancing Tissue Culture with Light-Driven 3D-Printed Microfluidic Devices

Li,

Wang,

Davis

et al. 2024

Biosensors

View full text Add to dashboard Cite

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“…3D printing has been widely implemented in many fields, including chemistry, biology, medicine, engineering, and industry [ 2 , 3 , 4 ]. The use of novel materials for 3D printing is constantly expanding, reducing the cost of prototypes, decreasing the time needed to produce them, and creating the possibility of testing innovative types of materials in many areas of science [ 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Microwave-Induced Processing of Free-Standing 3D Printouts: An Effortless Route to High-Redox Kinetics in Electroanalysis

Kozłowska,

Cieślik,

Koterwa

et al. 2024

Materials

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3D-printable composites have become an attractive option used for the design and manufacture of electrochemical sensors. However, to ensure proper charge-transfer kinetics at the electrode/electrolyte interface, activation is often required, with this step consisting of polymer removal to reveal the conductive nanofiller. In this work, we present a novel effective method for the activation of composites consisting of poly(lactic acid) filled with carbon black (CB-PLA) using microwave radiation. A microwave synthesizer used in chemical laboratories (CEM, Matthews, NC, USA) was used for this purpose, establishing that the appropriate activation time for CB-PLA electrodes is 15 min at 70 °C with a microwave power of 100 W. However, the usefulness of an 80 W kitchen microwave oven is also presented for the first time and discussed as a more sustainable approach to CB-PLA electrode activation. It has been established that 10 min in a kitchen microwave oven is adequate to activate the electrode. The electrochemical properties of the microwave-activated electrodes were determined by electrochemical techniques, and their topography was characterized using scanning electron microscopy (SEM), Raman spectroscopy, and contact-angle measurements. This study confirms that during microwave activation, PLAs decompose to uncover the conductive carbon-black filler. We deliver a proof-of-concept of the utility of kitchen microwave-oven activation of a 3D-printed, free-standing electrochemical cell (FSEC) in paracetamol electroanalysis in aqueous electrolyte solution. We established satisfactory limits of linearity for paracetamol detection using voltammetry, ranging from 1.9 μM to 1 mM, with a detection limit (LOD) of 1.31 μM.

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Advances in AI-assisted biochip technology for biomedicine

Rodoplu Solovchuk

2024

Biomedicine & Pharmacotherapy

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Recent advances in 3D-printing-based organ-on-a-chip

Cited by 3 publications

References 261 publications

Advancing Tissue Culture with Light-Driven 3D-Printed Microfluidic Devices

Advancing Tissue Culture with Light-Driven 3D-Printed Microfluidic Devices

Microwave-Induced Processing of Free-Standing 3D Printouts: An Effortless Route to High-Redox Kinetics in Electroanalysis

Advances in AI-assisted biochip technology for biomedicine

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