Onycholemmal carcinoma with prominent dystrophic calcification and review of the literature

Gaddis, Kevin J.; Wolfe, Jonathan; Shin, Thuzar M.; Rubin, Adam I.

doi:10.1111/cup.13313

Cited by 4 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In some reported cases, including ours, OC is described as painful but reporting on symptomatology is inconsistent and it is possible that some are painless. As with other subtypes of SCC involving the nail unit, the indolent nature and variable clinical features of OC may contribute to missed and delayed diagnosis [1,2,[9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…In the eight reports that included imaging, only 3 cases showed osteolysis, soft Nail Squamous Cell Carcinoma Skin Appendage Disord 2023;9:284-290 DOI: 10.1159/000529906 tissue edema, calcifications, or enhancement. The length of time between treatment and follow-up ranged from 3 months to 4 years with an average of 1 year and 7 months, with no identified recurrences [1][2][3][4][5][6][7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

“…No standardized treatment of nail unit SCC with onycholemmal features has been established. Of the reported cases in which the method of treatment was provided (N = 14), nine (60%) were treated with amputation or disarticulation of the involved phalanx, two (13%) were treated with Mohs micrographic surgery, two with excision, and one with radiation [1][2][3][4][5][6][7][8][9][10]. One study proposed a method of intraoperative diagnosis of invasive epithelial malignant nonpigmented nail tumors, such as OC, using ex vivo fluorescence confocal microscopy (FCM).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Nail Unit Squamous Cell Carcinoma with Onycholemmal Features: Case Report and Review of the Literature

Waterton

Magro

Lipner

2023

Skin Appendage Disord

View full text Add to dashboard Cite

Introduction: Onycholemmal carcinoma (OC) is a rare subtype of squamous cell carcinoma (SCC) that originates from the epithelium of the nail bed. It is characterized by distinct histopathologic features including small clusters of atypical squamous epithelium devoid of a granular layer, with abrupt onycholemmal keratinization. Case Presentation: We present a case of a 75-year-old male with right thumbnail onycholysis, yellow-green nail plate discoloration, as well as bleeding and purulence of the lateral nail fold. Histopathologic evaluation revealed high-grade squamous dysplasia, small clusters of severely atypical epithelial cells, and a pattern of abrupt keratinization consistent with the diagnosis of SCC carcinoma with onycholemmal features. GMS and PAS staining indicated concomitant onychomycosis. Pathologic analysis also disclosed residual SCC and concomitant amyloidosis, possibly light chain related and hence reflective of his underlying multi-organ lymphoplasmacytic lymphoma. The patient subsequently underwent Mohs micrographic surgery. Conclusion: Clinical presentation of nail unit SCC with onycholemmal features is highly variable, making differentiating between similarly presenting benign and malignant nail disorders particularly challenging. This case report demonstrates clinical and histopathological features of nail unit SCC with onycholemmal features to improve diagnosis and management.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nail Unit Squamous Cell Carcinoma with Onycholemmal Features: Case Report and Review of the Literature

Waterton

Magro

Lipner

2023

Skin Appendage Disord

View full text Add to dashboard Cite

show abstract

“…However, there is still no known relationship between the viral infection and OC. 6,9 The differential diagnosis for OC includes nail unit SCC, malignant proliferating onycholemmal cyst, subungual keratoacanthomas, subungual calcified epidermoid inclusions, and verrucous carcinoma. SCC, in particular, is an important tumor to rule out because it is the most common cutaneous neoplasm of the hand albeit rare in the nail bed.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, all cases reported thus far have not demonstrated recurrence. [1][2][3][5][6][7] During his postradiation follow-up appointment, our patient's exam displayed full functionality of his left thumb and regrowth of the nail plate.…”

Section: Discussionmentioning

confidence: 99%

Indolent, Painful, and Dystrophic Nail Unit Tumor in an Elderly Man: Answer

Chittoor

Schaffenburg

Braden

et al. 2021

The American Journal of Dermatopathology

Self Cite

View full text Add to dashboard Cite

Perinatal pharmacoepidemiology: How often are key methodological elements reported in publications?

Margulis¹,

Kawai

Anthony

et al. 2021

Pharmacoepidemiology and Drug

View full text Add to dashboard Cite

Purpose: Publications provide important information for clinicians, researchers, and patients. Key methodological elements must be reported for maximum transparency.We identified key methodological elements necessary for fully understanding perinatal pharmacoepidemiology research and quantified the proportion of studies that reported these elements in a sample of publications.Methods: Key methodological elements were identified from guidelines from regulatory agencies, literature, and subject-matter knowledge: source of information to determine pregnancy start; mother-or father-infant linkages (process, success rate); unit of analysis; and whether non-live births and fetuses with various anomalies were included in the study population. We conducted a literature review for recent observational studies on medical product utilization or safety during pregnancy and estimated the prevalence of reporting these elements.Results: Data were extracted from a random sample of 100 publications; 8% were published in epidemiology/pharmacoepidemiology journals; 85% were medical product-safety studies. Of publications for which each element was applicable, 43% reported the source for determining pregnancy start; 57%, whether the study population included multifetal pregnancies; 39%, whether it included more than one pregnancy per woman; 27%, whether it included fetuses with chromosomal abnormalities; 60%, fetuses with major congenital malformations; and 93%, non-live births. Of the 20 studies with mother-infant linkage, 35% described the process; 21% reported the linkage success rate. Among studies with more than one pregnancy/ offspring per woman, 22% reported methods addressing sibling correlation. Conclusions:In this sample of pregnancy-related pharmacoepidemiology publications, completeness of reporting could have been improved. A pregnancy-specific checklist would increase transparency in the dissemination of study results.

show abstract

Onycholemmal carcinoma with prominent dystrophic calcification and review of the literature

Cited by 4 publications

References 10 publications

Nail Unit Squamous Cell Carcinoma with Onycholemmal Features: Case Report and Review of the Literature

Nail Unit Squamous Cell Carcinoma with Onycholemmal Features: Case Report and Review of the Literature

Indolent, Painful, and Dystrophic Nail Unit Tumor in an Elderly Man: Answer

Perinatal pharmacoepidemiology: How often are key methodological elements reported in publications?

Contact Info

Product

Resources

About