Onycholemmal carcinoma: A case report with its molecular profiling

Onycholemmal carcinoma with prominent dystrophic calcification and review of the literature

“…Additionally, one Case was analyzed for molecular alterations. None of the fourteen analyzed genetic loci revealed pathogenic mutations; the authors hypothesized that pathogenic mutations may be present in the p16/Rb/E2F pathway …”

“…Recognition of this entity is important to ensure that appropriate, but not excessively aggressive, management is pursued. Among Cases with reported treatments, nine of thirteen (69%) lesions were treated by amputation or distal interphalangeal joint disarticulation . One lesion was managed with radiation, one with Mohs surgery, and two with more conservative re‐excisions .…”

“…Among cases with reported treatments, nine of thirteen (69%) lesions were treated by amputation or distal interphalangeal joint disarticulation. [1][2][3][4][5]7,10 One lesion was managed with radiation, one with Mohs surgery, and two with more conservative re-excisions. 1 To date, none of the reported cases have recurred locally.…”

“…In contradistinction to conventional squamous cell carcinoma, squamous pearls and single‐cell keratinization have not been reported in onycholemmal carcinoma. While HPV is a known driver in some periungual squamous cell carcinomas, HPV testing has been negative in two previously reported Cases . Additionally, one Case was analyzed for molecular alterations.…”

“…Since its initial description in 2004, approximately thirteen cases have been reported in the English‐language literature . These cases are summarized in Table .…”