2009
DOI: 10.1016/j.fsi.2008.11.018
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Ontogeny of lymphoid organs and development of IgM-bearing cells in Atlantic halibut (Hippoglossus hippoglossus L.)

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Cited by 44 publications
(37 citation statements)
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References 62 publications
(99 reference statements)
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“…In turbot, Fournier-Betz et al (2000) reported the presence of this cell type mainly in the outer zone of the thymus. In our study, Ig+ cells were located in the inner zone as was pointed out in the Atlantic halibut (Patel et al 2009) and mostly in the transitional region between inner and outer zones as was observed in other fish species such as rainbow trout ). Although in the previous report of Fournier-Betz et al (2000) as in our study the fish were not experimentally exposed to antigens, the differences observed in Ig+ cell distribution may be related to the previous immunological history of each group.…”
Section: Discussionsupporting
confidence: 82%
“…In turbot, Fournier-Betz et al (2000) reported the presence of this cell type mainly in the outer zone of the thymus. In our study, Ig+ cells were located in the inner zone as was pointed out in the Atlantic halibut (Patel et al 2009) and mostly in the transitional region between inner and outer zones as was observed in other fish species such as rainbow trout ). Although in the previous report of Fournier-Betz et al (2000) as in our study the fish were not experimentally exposed to antigens, the differences observed in Ig+ cell distribution may be related to the previous immunological history of each group.…”
Section: Discussionsupporting
confidence: 82%
“…Studies integrating gene expression and in situ detection of Igs in fish are scarce, and they depict a great variability among fish species and pathogens. In Atlantic halibut lymphoid organs, a positive correlation was observed between IgM expression and ISHIgMþ cells in Hk and Sp [35], whereas in European sea bass experimentally infected with betanodavirus, up-regulation of IgM in Hk occurred weeks before the number of B-cells from blood increased [36]. The ciliate Ichthyophthirius multifilis increased the IgM expression in the gills of rainbow trout, which was related to an active efflux of IgM-IRCs through the lamellar capillaries towards the site of infection [22].…”
Section: Discussionmentioning
confidence: 88%
“…In mammals, ZAP-70 is found to be exclusively expressed in all major thymocyte populations and NK cells [55,77]. Syk on the other hand, is found to be most abundantly expressed in Bcells [77,78], and the expression pattern of a halibut Syk gene would therefore be expected to be more similar to the IgM expression pattern of halibut [79]. The expression pattern of halibut ZAP-70 is thereby a confirmation of its homology, in addition to its high sequence conservation and the phylogenetic analysis grouping the halibut ZAP-70 sequence together with other known ZAP-70 sequences with high bootstrap support ( Figure 1C).…”
Section: Discussionmentioning
confidence: 99%