Ontogeny of lymphoid organs and development of IgM-bearing cells in Atlantic halibut (Hippoglossus hippoglossus L.)

Patel, Sonal; Sørhus, Elin; Fiksdal, Ingrid Uglenes; Espedal, Per Gunnar; Bergh, Øivind; Rødseth, Odd Magne; Morton, H. Craig; Nerland, Audun Helge

doi:10.1016/j.fsi.2008.11.018

Cited by 44 publications

(37 citation statements)

References 62 publications

(99 reference statements)

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“…In turbot, Fournier-Betz et al (2000) reported the presence of this cell type mainly in the outer zone of the thymus. In our study, Ig+ cells were located in the inner zone as was pointed out in the Atlantic halibut (Patel et al 2009) and mostly in the transitional region between inner and outer zones as was observed in other fish species such as rainbow trout ). Although in the previous report of Fournier-Betz et al (2000) as in our study the fish were not experimentally exposed to antigens, the differences observed in Ig+ cell distribution may be related to the previous immunological history of each group.…”

Section: Discussionsupporting

confidence: 82%

Morphological and immunohistochemical characterisation of the thymus in juvenile turbot (Psetta maxima, L.)

Vigliano

Losada

Castello³

et al. 2011

Cell Tissue Res

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We performed structural and immunohistochemical studies on the thymus of juvenile turbot (Psetta maxima L.) in order to define its cellular composition. The thymic stroma was mainly composed of two subpopulations of reticulo-epithelial cells (RECs). RECs immunoreactive to anti-actin antibody were distributed through the organ, while RECs that were cytokeratin-immunopositive were located in the outer zone of the thymus. The parenchyma of the thymus was composed of several cell types such as lymphocytes/thymocytes, lymphoblasts, melano-macrophages and to a lesser extent of nurse-like cells, immunoglobulin positive (Ig+) cells, mucous cells, rodlet cells and neuroendocrine cells. CD3ε+ lymphocytes were mainly located in the outer zone. On the other hand, Ig+ cells were observed in the transitional region between the inner and outer zones of the thymus. The neuroendocrine cells were large and exhibited immunoreactivity to neuropeptide Y and vasoactive intestinal polypeptide. They were located in the inner zone of the thymus in close association with lymphoblasts and lymphocytes/thymocytes. This work provides useful information on the structure and cellular composition of the thymus of turbot, identifying several immunomarkers that allow the identification of different cell types, providing the basis for further studies on the immune response of turbot against diseases.

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Section: Discussionsupporting

confidence: 82%

Morphological and immunohistochemical characterisation of the thymus in juvenile turbot (Psetta maxima, L.)

Vigliano

Losada

Castello³

et al. 2011

Cell Tissue Res

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“…Studies integrating gene expression and in situ detection of Igs in fish are scarce, and they depict a great variability among fish species and pathogens. In Atlantic halibut lymphoid organs, a positive correlation was observed between IgM expression and ISHIgMþ cells in Hk and Sp [35], whereas in European sea bass experimentally infected with betanodavirus, up-regulation of IgM in Hk occurred weeks before the number of B-cells from blood increased [36]. The ciliate Ichthyophthirius multifilis increased the IgM expression in the gills of rainbow trout, which was related to an active efflux of IgM-IRCs through the lamellar capillaries towards the site of infection [22].…”

Section: Discussionmentioning

confidence: 88%

Modulation of the IgM gene expression and IgM immunoreactive cell distribution by the nutritional background in gilthead sea bream (Sparus aurata) challenged with Enteromyxum leei (Myxozoa)

Estensoro

Calduch-Giner

Kaushik

et al. 2012

Fish & Shellfish Immunology

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“…In mammals, ZAP-70 is found to be exclusively expressed in all major thymocyte populations and NK cells [55,77]. Syk on the other hand, is found to be most abundantly expressed in Bcells [77,78], and the expression pattern of a halibut Syk gene would therefore be expected to be more similar to the IgM expression pattern of halibut [79]. The expression pattern of halibut ZAP-70 is thereby a confirmation of its homology, in addition to its high sequence conservation and the phylogenetic analysis grouping the halibut ZAP-70 sequence together with other known ZAP-70 sequences with high bootstrap support ( Figure 1C).…”

Section: Discussionmentioning

confidence: 99%

Cloning, characterization, and expression pattern of Atlantic halibut (Hippoglossus hippoglossus L.) CD4-2, Lck, and ZAP-70

Øvergård

Nerland

Patel

2010

Fish & Shellfish Immunology

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Havforskningsinstituttets institusjonelle arkiv Brage IMR - Institutional repository of the Institute of Marine Research b r a g e i m rDette er forfatters siste versjon av den fagfellevurderte artikkelen, vanligvis omtalt som postprint. I Brage IMR er denne artikkelen ikke publisert med forlagets layout fordi forlaget ikke tillater dette. Du finner lenke til forlagets versjon i Brage-posten. Det anbefales at referanser til artikkelen hentes fra forlagets side. Ved lenking til artikkelen skal det lenkes til post i Brage IMR, ikke direkte til pdf-fil.This is the author's last version of the article after peer review and is not the publisher's version, usually referred to as postprint. You will find a link to the publisher's version in Brage IMR. It is recommended that you obtain the references from the publisher's site.Linking to the article should be to the Brage-record, not directly to the pdf-file.

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Ontogeny of lymphoid organs and development of IgM-bearing cells in Atlantic halibut (Hippoglossus hippoglossus L.)

Cited by 44 publications

References 62 publications

Morphological and immunohistochemical characterisation of the thymus in juvenile turbot (Psetta maxima, L.)

Morphological and immunohistochemical characterisation of the thymus in juvenile turbot (Psetta maxima, L.)

Modulation of the IgM gene expression and IgM immunoreactive cell distribution by the nutritional background in gilthead sea bream (Sparus aurata) challenged with Enteromyxum leei (Myxozoa)

Cloning, characterization, and expression pattern of Atlantic halibut (Hippoglossus hippoglossus L.) CD4-2, Lck, and ZAP-70

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