Ontogeny of Acute Tolerance to Ethanol‐Induced Social Inhibition in Sprague–Dawley Rats

Varlinskaya, Elena I.; Spear, Linda P.

doi:10.1111/j.1530-0277.2006.00220.x

Cited by 56 publications

(74 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, while acute ethanol induces greater levels of motor in-coordination in the adolescent brain, there is enhanced tolerance to an acute challenge of ethanol following prolonged exposure (Swartwelder, et al, 1998). Similarly, it was recently reported that adolescent rats exhibit enhanced acute tolerance to ethanol-induced social inhibition (Varlinskaya and Spear, 2006). Together, these observations are consistent with heightened plasticity of the adolescent brain as it relates adaptive changes in response to ethanol exposure.…”

Section: Heightened Vulnerability Of the Adolescent Brain To Addictivsupporting

confidence: 81%

Adaptive plasticity of NMDA receptors and dendritic spines: Implications for enhanced vulnerability of the adolescent brain to alcohol addiction

Carpenter-Hyland

Chandler

2007

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

It is now known that brain development continues into adolescence and early adulthood and is highly influenced by experience-dependent adaptive plasticity during this time. Behaviorally, this period is also characterized by increased novelty-seeking and risk-taking. This heightened plasticity appears to be important in shaping behaviors and cognitive processes that contribute to proper development of an adult phenotype. However, increasing evidence has linked these same experience-dependent learning mechanisms with processes that underlie drug addiction. As such, the adolescent brain appears be particularly susceptible to experience-dependent learning processes associated with consumption of alcohol and addictive drugs. At the level of the synapse, homeostatic changes during ethanol consumption are invoked to counter the destabilizing effects of ethanol on neural networks. This homeostatic response may be especially pronounced in the adolescent and young adult brain due to its heightened capacity to undergo experience-dependent changes, and appears to involve increased synaptic targeting of NMDA receptors. Interestingly, recent work from our lab also indicates that the enhanced synaptic localization of NMDA receptors promotes increases in the size of dendritic spines. This increase may represent a structural-based mechanism that supports the formation and stabilization of maladapted synaptic connections that, in a sense, "fix" the addictive behavior in the adolescent and young adult brain.

show abstract

Section: Heightened Vulnerability Of the Adolescent Brain To Addictivsupporting

confidence: 81%

Adaptive plasticity of NMDA receptors and dendritic spines: Implications for enhanced vulnerability of the adolescent brain to alcohol addiction

Carpenter-Hyland

Chandler

2007

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

show abstract

“…Finally, adolescent animals have also been found to be differentially sensitive to the acute effects of other CNS depressants that do not share the same pharmacokinetic mechanisms as toluene. Indeed, previous studies have shown that the degree to which a specific drug will affect adolescents differently than adults may be affected by multiple factors, including the specific behavior measured [55], the exact age of the animal [59], and the route of administration [43]. For example, adolescent rodents are less sensitive to ethanol-induced motor disruption and loss of righting reflex than are adult rodents [23,33].…”

Section: Discussionmentioning

confidence: 99%

Decreased sensitivity in adolescent vs. adult rats to the locomotor activating effects of toluene

Bowen¹,

Charlesworth²,

Tokarz³

et al. 2007

Neurotoxicology and Teratology

View full text Add to dashboard Cite

Volatile organic solvent (inhalant) abuse continues to be a major health concern throughout the world. Of particular concern is the abuse of inhalants by adolescents because of its toxicity and link to illicit drug use. Toluene, which is found in many products such as glues and household cleaners, is among the most commonly abused organic solvents. While studies have assessed outcomes of exposure to inhalants in adult male animals, there is little research on the neurobehavioral effects of inhalants in female or younger animals. In attempt to address these shortcomings, we exposed male and female Long-Evans rats to 20 min of 0, 2,000, 4,000, or 8,000 parts per million (ppm) inhaled toluene for 10 days in rats aged postnatal (PN) day 28-39 (adolescent), PN44-PN55, or >PN70 (adult). Animals were observed individually in 29-l transparent glass cylindrical jars equipped with standard photocells that were used to measure locomotor activity. Toluene significantly increased activity as compared to air exposure in all groups of male and female rats with the magnitude of locomotor stimulation produced by 4000 ppm toluene being significantly greater for female adults than during any age of adolescence. The results demonstrate that exposure to abuse patterns of high concentrations of toluene through inhalation can alter spontaneous locomotor behavior in rats and that the expression of these effects appears to depend upon the postnatal age of testing and sex of the animal.

show abstract

“…Another sample of socially-isolated males was tested under the baseline conditions for aggression (Day 1) in novel Low-Low and RandomRandom pairs. Twenty-four hours later (Day 2) one member of each pair was injected with 1g/kg of 10% ethanol (a moderate -high dose: Varlinskaya and Spear, 2006) 10 min prior to exposure to its previous day's partner in the neutral environment. On both days pairs engaged in social interaction for 10 min, during which behaviors were videotaped for later scoring and analysis.…”

Section: Low Usv Line Male-male Aggressionmentioning

confidence: 99%

Developmental Effects of Selective Breeding for an Infant Trait

Brunelli

Zimmerberg

Hofer

2010

Handbook of Developmental Science, Behavior, and Genetics

View full text Add to dashboard Cite

Ontogeny of Acute Tolerance to Ethanol‐Induced Social Inhibition in Sprague–Dawley Rats

Cited by 56 publications

References 59 publications

Adaptive plasticity of NMDA receptors and dendritic spines: Implications for enhanced vulnerability of the adolescent brain to alcohol addiction

Adaptive plasticity of NMDA receptors and dendritic spines: Implications for enhanced vulnerability of the adolescent brain to alcohol addiction

Decreased sensitivity in adolescent vs. adult rats to the locomotor activating effects of toluene

Developmental Effects of Selective Breeding for an Infant Trait

Contact Info

Product

Resources

About