Onset of Breast and Pubic Hair Development and Menses in Urban Chinese Girls

Ma, Huamei; Du, Mingmei; Luo, Xiaoping; Chen, Shao-Ke; Liu, Li; Chen, Rui-Min; Zhu, Changlian; Xiong, Feng; Li, Tang; Wang, Wei; Liu, Geli

doi:10.1542/peds.2008-2638

Cited by 107 publications

(82 citation statements)

References 29 publications

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“…From the 1960s, this decline in AAM in the USA and in Europe seems to have leveled off, although minor but statistically significant decreases of 2.5-4 months have been reported during the past three decades [8]. Moreover, the pattern described in our study is more comparable to the one observed in developing countries [16,17,18,19] in which there appears to be a decline in mean AAM in the second half of the 20th century. However, the decline reported in the present study seems to be less steep than observed in these populations, beginning at a lower AAM in the late 1800s and early 1900s than reported in developing countries or in developed countries.…”

Section: Discussionsupporting

confidence: 65%

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Long-Term Secular Trends in the Age at Menarche in Israel: A Systematic Literature Review and Pooled Analysis

Flash-Luzzatti

Weil²,

Shalev³

et al. 2014

Horm Res Paediatr

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Background/Aims: A worldwide decline in the age at menarche (AAM) has been reported in recent decades. This trend has been also clinically observed among Israeli women and was reported in our previous study. Methods: We reviewed the literature reporting the mean AAM in Israel during the past century. Studies were excluded if participants had been investigated due to illness or any condition which could affect sexual maturation. Mean AAM was analyzed using a simple linear regression weighted for number of participants in each birth cohort and stratified to birth cohorts before and after 1970, based on the outcome of our previous study. Results: AAM varied little among women born between 1875 and 1970, but there was a clear downwards trend from 13.4 in 1970 to 12.8 two decades later. In a stratified analysis we found a significant negative association between birth year and AAM in the birth cohort after 1970 (standardized β coefficient = -0.94 per year, R² = 0.87; p < 0.001). Conclusion: These results suggest a significant decline in mean AAM in Israeli women born in 1970 or later.

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Section: Discussionsupporting

confidence: 65%

“…Several reports from the USA and Europe described a decrease in AAM of 2.5-4 months in the last quarter of a century [7,8]. In contrast, during similar periods a dramatic decrease in AAM was reported in cross-sectional studies from developing areas in China [16], Mexico [17], South Africa [18] and Korea [19]. …”

Section: Introductionmentioning

confidence: 97%

Long-Term Secular Trends in the Age at Menarche in Israel: A Systematic Literature Review and Pooled Analysis

Flash-Luzzatti

Weil²,

Shalev³

et al. 2014

Horm Res Paediatr

View full text Add to dashboard Cite

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“…The secular trend to earlier pubertal maturation was observed especially in girls [5][6][7][8], possibly because of improved nutrition and increased socioeconomic status that corresponded with the markedly increased prevalence of obesity in Thai school children in the recent years [9]. In girls, earlier age at menarche was reported after exposure to many endocrine disrupters such as polychlorinated biphenyls (PCBs), polybrominated biphenyls, pesticides-dichlorodiphenyltrichloroethane (DDT), and phthalate esters.…”

Section: Discussionmentioning

confidence: 99%

The age of onset of pubertal development in healthy Thai boys in Khon Kaen, Thailand

et al. 2015

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Background: There is variation of the age of onset of puberty in a population. The secular trends in the timing of pubertal development have decreased in some parts of the world. Objective: To determine the age of pubertal development in healthy Thai boys in Khon Kaen, Thailand and compare it with that in previous studies of Thai boys. Methods: A descriptive, cross-sectional study was performed in 316 school boys aged 5−16 years between May and July 2011. Development of the genitals and pubic hair was determined by Tanner staging, and testicular volume was assessed using a Prader orchidometer. All boys were examined by a male pediatrician. Results: Genital stage of puberty in boys occurred at a median age of 11.3 years and a mean ± SD age of 11.3 ± 1.3 (mean ± SD, range 8.0−14.9) years, and pubarche occurred at a median age of 12.8 years and a mean ± SD of 12.5 ± 1.2 years (range 9.1-14.9) years. Conclusions: No secular trend towards earlier age at pubertal onset for gonadarche in Khon Kaen boys, but pubarche seems to be later than found in previous studies in Thai boys.

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“…However, a minority (10-18.4%) may progress to true precocious puberty with a positive association between older age at presentation (mostly after 2 years of age) and the progression to precocious puberty [40]. There is a secular trend towards an increasing prevalence of premature puberty, especially early breast development in school-aged girls [41,42]. This trend has been attributed to in utero and childhood exposure to endocrine-disrupting compounds ubiquitously present in food and the environment [43,44].…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Polybrominated Diphenyl Ethers in Girls with Premature Thelarche

et al. 2016

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Background/Aims: Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants and have shown endocrine disruption properties in experimental studies. The aim of this study was to investigate the association between the exposure to PBDEs and alterations of puberty in girls referred for idiopathic central precocious puberty (ICPP) and premature thelarche (PT). Methods: A case-control study was conducted in 124 girls: 37 girls with ICPP (mean age 7.4 ± 0.9 years), 56 with PT (mean age 5.7 ± 2.1 years) and 31 controls (mean age 5.4 ± 1.9 years). PBDE serum concentrations, hormone levels and anthropometry were assessed. PBDE concentrations were corrected for total serum lipid content. Individual exposure to PBDEs was evaluated through ad hoc questionnaires. Results: PBDE serum concentrations corrected for total lipid content were significantly higher in girls with PT (mean 1.49 ± 0.63 log ng/g) than in controls (mean 1.23 ± 0.54 log ng/g; p < 0.05). PT girls showed higher levels of PBDE than ICPP girls (1.49 ± 0.63 vs. 1.37 ± 0.49 log ng/g), though this was not significant. An analysis of the questionnaires revealed no significant differences in exposure between the three groups. Conclusion: Our findings suggest that higher concentrations of serum PBDEs are associated with PT in girls.

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Onset of Breast and Pubic Hair Development and Menses in Urban Chinese Girls

Cited by 107 publications

References 29 publications

Long-Term Secular Trends in the Age at Menarche in Israel: A Systematic Literature Review and Pooled Analysis

Long-Term Secular Trends in the Age at Menarche in Israel: A Systematic Literature Review and Pooled Analysis

The age of onset of pubertal development in healthy Thai boys in Khon Kaen, Thailand

Serum Levels of Polybrominated Diphenyl Ethers in Girls with Premature Thelarche

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