2017
DOI: 10.1177/1526602817740133
|View full text |Cite
|
Sign up to set email alerts
|

One-Year Outcomes Following Directional Atherectomy of Popliteal Artery Lesions: Subgroup Analysis of the Prospective, Multicenter DEFINITIVE LE Trial

Abstract: Purpose: To report the effectiveness of directional atherectomy for the treatment of popliteal artery occlusive disease. Methods: This subset of the prospective, multicenter, single-arm DEFINITIVE LE trial included 158 patients (mean age 72.0±10.9 years; 82 men) who underwent directional atherectomy in 162 popliteal artery lesions between 2009 and 2011. Forty-eight (30.4%) patients were suffering from critical limb ischemia (CLI). The mean lesion length was 5.8±3.9 cm; 38 (23.5%) arteries were occluded. The pr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
33
0
3

Year Published

2017
2017
2022
2022

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 39 publications
(37 citation statements)
references
References 26 publications
0
33
0
3
Order By: Relevance
“…A subgroup analysis of the DEFINITE LE trial is one of the largest studies examining BTK atherectomy efficacy. The 1‐year primary patency of 189 lesions (mean lesion length 58 mm) in 145 patients treated with stand‐alone directional atherectomy was 84%, and freedom from major amputation was 97% (94% in patients with CLI) at 1‐year . The OASIS (Orbital Atherectomy System for the Treatment of Peripheral Vascular Stenosis) trial of 201 lesions (mean lesion length 30 mm) in 124 patients reported a 90% procedural success rate (final stenosis ≤30%) and an improvement of 78% in Rutherford classification .…”
Section: Discussionmentioning
confidence: 99%
“…A subgroup analysis of the DEFINITE LE trial is one of the largest studies examining BTK atherectomy efficacy. The 1‐year primary patency of 189 lesions (mean lesion length 58 mm) in 145 patients treated with stand‐alone directional atherectomy was 84%, and freedom from major amputation was 97% (94% in patients with CLI) at 1‐year . The OASIS (Orbital Atherectomy System for the Treatment of Peripheral Vascular Stenosis) trial of 201 lesions (mean lesion length 30 mm) in 124 patients reported a 90% procedural success rate (final stenosis ≤30%) and an improvement of 78% in Rutherford classification .…”
Section: Discussionmentioning
confidence: 99%
“…arteries (1)(2)(3)(4). These events may be even more frequent in presence of severe calcifications of the target lesions.…”
Section: A B C D E Fmentioning
confidence: 99%
“…Restenosis rate after percutaneous transluminal angioplasty (PTA) of isolated calcified popliteal artery lesion makes this endovascular procedure still debated. Indeed, the presence of severe calcification of the atherosclerotic target lesion is responsible for a poor response to balloon dilation, due to significant acute vessel recoil and frequent dissection, limiting technical success rate and long-term patency (1)(2)(3). Directional atherectomy (DA) may be an alternative treatment modality that can improve procedural success by debulking fibrocalcific portion of the plaque, but provides benefits in terms of patency rate only when combined with angioplasty (3,4).…”
Section: Introductionmentioning
confidence: 99%
“…The safety and efficacy of directional atherectomy devices have been investigated in several prospective multicentre studies. [13][14][15][16][17][18] The first independently adjudicated prospective multicentre trial investigating the safety and efficacy of directional atherectomy was the Determination of Effectiveness of SilverHawk Peripheral Plaque Excision for the Treatment of Infrainguinal Vessels (DEFINITIVE LE). It involved 800 patients with claudication symptoms or CLI who were enrolled at 50 sites in the US and Europe.…”
Section: Directional Atherectomymentioning
confidence: 99%