One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease

Chronic resveratrol administration improves diabetic cardiomyopathy in part by reducing oxidative stress

“…In this context, it has been reported that resveratrol administration in patients with stable coronary artery disease (8-10 mg/kg for 3 and 12 months), improved LV diastolic pressure and circulatory proinflammatory markers respectively [26,27]. Also, Militaru et al [28] have shown that 60 days' treatment with resveratrol decreased inflammatory markers in patients with stable angina pectoris.…”

“…Antioxidant and cardioprotective properties of resveratrol have been documented by a variety of animal studies and human clinical trials [2,5,26,27]. In this context, it has been reported that resveratrol administration in patients with stable coronary artery disease (8-10 mg/kg for 3 and 12 months), improved LV diastolic pressure and circulatory proinflammatory markers respectively [26,27].…”

Resveratrol Partially Suppresses Inflammatory Events but Does not Affect Stroke Onset in Stroke-Prone Spontaneously Hypertensive Rats

“…Moreover, resveratrol significantly improves the mean hemoglobin A1c levels, systolic blood pressure and total cholesterol levels in type 2 diabetes mellitus patients 33,34) , and treatment with a resveratrol-enriched grape extract was demonstrated to significantly decrease the LDL-cholesterol, apoB and oxidized LDL levels and increase the non-HDL-cholesterol/apoB ratio 35) . Finally, resveratrol-enriched grape extract treatment also significantly decreases the high-sensitivity C-reactive protein, TNF-, plasminogen activator inhibitor type 1 levels, as well as the IL-6/IL-10 ratio, and increases the IL-10 level 36) , and resveratrol therapy has been shown to lead to dose-dependent increases in the cerebral blood flow, although it does not affect the cognitive function 37) , in addition to reducing tumor cell proliferation by 5% in patients with colorectal cancer 38) . These findings suggest that resveratrol can prevent various diseases in human subjects.…”

Beneficial Effects of Grape Resveratrol on Serum Adiponectin and Inflammation: Clinical Trial in Patients with Stable Coronary Artery Disease

“…Upon resveratrol intervention the gene expression pattern of these genes are drastically modulated. These authors have previously shown a clear benefit of UV treated grape extract in stable CAD patients, by increasing the level of pleotropic adipokine, adiponectin, and decreasing PAI-1, IL-6, and TNF-α inflammatory cytokines [36].…”

“…Acute and chronic stimulation by TNF-α activates PKC, PI3K, MAPK and NF-kB signaling pathways leading to induction of PAI-1 expression [31]. Resveratrol can also inhibit TNF-α induced PAI-1 formation and the activation of the NF-kB pathway [36]. Macrophages are important inflammatory cells involved in the initiation of inflammation process and pathogenesis of many diseases including CAD.…”