One-Step Three-Component Synthesis of New 2,5,6,7-Functionalized 5,8-Dihydropyrido-[2,3-d]pyrimidin-4(3H)-ones

Melik-Ohanjanyan, R. G.; Hovsepyan, T. R.; Karakhanyan, G. S.; Israelyan, S. G.; Nersesyan, L. E.; Panosyan, G. A.

doi:10.1134/s1070428018010104

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Compound 77 exhibited potent anti-microbial activity against the Gram-positive Bacillus subtilis (Scheme 32). 106 Ohanjanyan et al 108 reported the synthesis of dihydropyrido [2,3-d]pyrimidin-4(3H)-ones 80a and 80b in 52% and 58% yields, respectively, via a multi-component reaction of 6-aminothiouracil 3 or 6 with aryl aldehydes 21 and pentane-2,4-dione 58 (Scheme 34, Table 15). 87) in ethanol at reflux and in the presence of trimethylamine as a catalyst (Scheme 38, Table 18).…”

Section: Table 8 Synthesis Of Compounds 54a-lmentioning

confidence: 99%

Aminouracil and aminothiouracil as versatile precursors for a variety of heterocyclic systems

Diab¹,

Salem²,

Abdelhamid³

et al. 2021

Arkivoc

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Heterocycles, particularly pyrimidine derivatives, which are present in many natural products and many interesting synthetic compounds, are the most diverse class of organic compounds and have significant chemical, biomedical and industrial applications. Uracil, a pyrimidine derivative, constitutes a promising structure in widespread natural products and many of its derivatives exhibited significant pharmacological properties. They have been widely used as starting materials for the synthesis of a huge number of biologically important nitrogen-containing heterocycles. This review casts light on various methods for the construction of different heterocyclic systems utilizing aminouracil and aminothiouracil as versatile precursors. The heterocyclic systems mentioned in this review are categorized according to the type of the heterocyclic systems.

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Section: Table 8 Synthesis Of Compounds 54a-lmentioning

confidence: 99%

Aminouracil and aminothiouracil as versatile precursors for a variety of heterocyclic systems

Diab¹,

Salem²,

Abdelhamid³

et al. 2021

Arkivoc

View full text Add to dashboard Cite

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Synthesis of Pyrimido[4, 5-b]quinolones from 6-Aminopyrimidin-4- (thi)one Derivatives (Part I)

Gouda

Abu‐Hashem

Ameen

et al. 2023

MROC

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Quinoline and pyrimidine are well-known moieties, which appear in various natural and synthetic products. Furthermore, quinoline-pyrimidine-inspired hybrids are known to have several biological properties. In addition, many pyrimido[4,5-b]quinolinone ring systems, specifically concerning medicinal chemistry, have been reported over the past decade. This review depicts the synthesis of pyrimido[4, 5-b] quinolones (PyQs4,5-b) through 6-aminopyrimidin-4-(thi)one derivatives. The preparation of PyQs4,5-b was clarified through the following chemical reactions: Vilsmeier-Haack formylation, Hantzsch-like reaction, and one-pot three-component reaction.

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One-Step Three-Component Synthesis of New 2,5,6,7-Functionalized 5,8-Dihydropyrido-[2,3-d]pyrimidin-4(3H)-ones

Cited by 2 publications

References 8 publications

Aminouracil and aminothiouracil as versatile precursors for a variety of heterocyclic systems

Aminouracil and aminothiouracil as versatile precursors for a variety of heterocyclic systems

Synthesis of Pyrimido[4, 5-b]quinolones from 6-Aminopyrimidin-4- (thi)one Derivatives (Part I)

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