One‐Step Synthesis of Folic Acid Protected Gold Nanoparticles and Their Receptor‐Mediated Intracellular Uptake

Li, Gaiping; Li, Dan; Zhang, Lixue; Zhai, Junfeng; Wang, Erkang

doi:10.1002/chem.200900914

Cited by 74 publications

(56 citation statements)

References 43 publications

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“…In this paper, an innovative technique has been developed by using MNP-Fe 3 O 4 under ELMF exposure to generated localized physical cell damage and eventually kills tumor cells. Comprehensive studies have reported the biological effects of external static or alterable magnetic field in the last decades313233343536373839. However, the specific mechanism of ELMF on biological system has not yet been fully investigated.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Tumor Treatment of Magnetic Nanoparticles Driven by Extremely Low Frequency Magnetic Field

Liu

Qian

et al. 2017

Sci Rep

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Recently, magnetic nanoparticles (MNPs), which can be manipulated in the magnetic field, have received much attention in tumor therapy. Extremely low frequency magnetic field (ELMF) system can initiate MNPs vibrating and the movement of MNPs inside of cells can be controlled by adjusting the frequency and intensity of ELMF towards irreversible cell damages. In this study, we investigated the detrimental effects on tumor cells with MNPs under various ELMF exposure conditions. An in-house built ELMF system was developed and utilized for evaluating the treatment efficiency of MNPs on tumor cells with specific intensities (2–20 Hz) and frequencies (0.1–20 mT). Significant morphological changes were found in tumor cells treated with MNPs in combing with ELMF, which were consistent with noticeable decrease in cell viability. With the increase of the intensity and frequency of the magnetic field, the structural integrity of tumor tissue can be further destroyed. Destructive effects of MNPs and ELMF on tumor tissues were further determined by the pathophysiological changes observed in vivo in animal study. Taken together, the combination of MNPs and ELMF had a great potential as an innovative treatment approach for tumor intervention.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Tumor Treatment of Magnetic Nanoparticles Driven by Extremely Low Frequency Magnetic Field

Liu

Qian

et al. 2017

Sci Rep

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“…Folate-functionalized gold nanoparticles are selectively internalized into cells expressing folate receptor, a process which is significantly inhibited by excess free folic acid (Li et al 2009). Several studies have employed folate as a targeting ligand for gold nanoparticles loaded with a chemotherapeutic cargo (Prabaharan et al 2009; Asadishad et al 2010; Patra et al 2010; Manju and Sreenivasan 2012).…”

Section: Resultsmentioning

confidence: 99%

Cancer active targeting by nanoparticles: a comprehensive review of literature

Bazak

Houri

Achy

et al. 2014

J Cancer Res Clin Oncol

586

359

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Purpose Cancer is one of the leading causes of death, and thus, the scientific community has but great efforts to improve cancer management. Among the major challenges in cancer management is development of agents that can be used for early diagnosis and effective therapy. Conventional cancer management frequently lacks accurate tools for detection of early tumors and has an associated risk of serious side effects of chemotherapeutics. The need to optimize therapeutic ratio as the difference with which a treatment affects cancer cells versus healthy tissues lead to idea that it is needful to have a treatment that could act a the “magic bullet”—recognize cancer cells only. Nanoparticle platforms offer a variety of potentially efficient solutions for development of targeted agents that can be exploited for cancer diagnosis and treatment. There are two ways by which targeting of nanoparticles can be achieved, namely passive and active targeting. Passive targeting allows for the efficient localization of nanoparticles within the tumor microenvironment. Active targeting facilitates the active uptake of nanoparticles by the tumor cells themselves. Methods Relevant English electronic databases and scientifically published original articles and reviews were systematically searched for the purpose of this review. Results In this report, we present a comprehensive review of literatures focusing on the active targeting of nanoparticles to cancer cells, including antibody and antibody fragment-based targeting, antigen-based targeting, aptamer-based targeting, as well as ligand-based targeting. Conclusion To date, the optimum targeting strategy has not yet been announced, each has its own advantages and disadvantages even though a number of them have found their way for clinical application. Perhaps, a combination of strategies can be employed to improve the precision of drug delivery, paving the way for a more effective personalized therapy.

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“…Hence, we would better come to the conclusion that MNP-Fe 3 O 4 did not a®ect important functions (such as chromosome function), but the mechanism of particles entering into the cell is not yet very clear. 35,36 During this experiment, cultured cells were divided into nine parts, including three control groups and six experiment groups. In control groups 1 and 2, the cells were only under LFAMF irradiation during 120 min.…”

Section: Discussionmentioning

confidence: 99%

Tumor therapy by fast moving magnetic nanoparticle under low-frequency alternating magnetic field

Liu

Qian

Yin

et al. 2015

J. Innov. Opt. Health Sci.

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Magnetic nanoparticle plays an important role in biomedical engineering, especially in tumor therapy. In this paper, a new technique has been developed by using the rapid moving magnetic nanoparticle under a low-frequency alternating magnetic¯eld (LFAMF) to kill tumor cells. The LFAMF system which was used to drive magnetic nanoparticles (MNPs) was setup with the magnetic¯eld frequency and power range at $ 10-100 Hz and $ 10-200 mT, respectively. During the experiment, the LFAMF was adjusted at di®erent frequencies and power levels. The experimental results show that the liver tumor cells (HepG2) mixed with MNPs (10 g/mL) became partial fragments when exposed in the LFAMF with di®erent frequencies ($ 10-100 Hz) and power ($ 10-200 mT), and the higher the frequency or the power, the more the tumor cells were killed at the same magnetic nanoparticle concentration. Conclusion: Tumor cells were e®ectively damaged by MNPs under LFAMF, which suggests that they had great potential to be applied in tumor therapy.

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One‐Step Synthesis of Folic Acid Protected Gold Nanoparticles and Their Receptor‐Mediated Intracellular Uptake

Cited by 74 publications

References 43 publications

Evaluation of Tumor Treatment of Magnetic Nanoparticles Driven by Extremely Low Frequency Magnetic Field

Evaluation of Tumor Treatment of Magnetic Nanoparticles Driven by Extremely Low Frequency Magnetic Field

Cancer active targeting by nanoparticles: a comprehensive review of literature

Tumor therapy by fast moving magnetic nanoparticle under low-frequency alternating magnetic field

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