Abstract:An initial burst is often observed during the release of active pharmaceutical ingredients (APIs) from poly-lactic-coglycolic-acid (PLGA) microparticles (MPs) which have been prepared by the emulsion-solvent evaporation method. Herein, we describe the development of a simple one-step coating method that suppresses the initial burst release process. This new method involves coating the PLGA-MPs with PLGA, with the coating process being performed through the phase separation of PLGA on the surface of PLGA-MPs us… Show more
“…14 Many efforts have been made to create approaches that allow main variables to be changed to reduce or eliminate the initial drug burst release, providing a so, smart material system with adequately improved release characteristics. 13,[15][16][17] In order to solve problems associated with burst release and the mechanical properties of so materials, inorganic nanoparticles appear suitable for both regulating the burst effect by creating an additional barrier against diffusion and meeting the stiffness needs.…”
Hydrogel nanocomposites of pectin, HEMA and titania for Vit-B12 controlled release with reduced initial release burst were prepared. A reduction of up to ca. 60% was observed.
“…14 Many efforts have been made to create approaches that allow main variables to be changed to reduce or eliminate the initial drug burst release, providing a so, smart material system with adequately improved release characteristics. 13,[15][16][17] In order to solve problems associated with burst release and the mechanical properties of so materials, inorganic nanoparticles appear suitable for both regulating the burst effect by creating an additional barrier against diffusion and meeting the stiffness needs.…”
Hydrogel nanocomposites of pectin, HEMA and titania for Vit-B12 controlled release with reduced initial release burst were prepared. A reduction of up to ca. 60% was observed.
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