Drug release profile and reduction in the in vitro burst release from pectin/HEMA hydrogel nanocomposites crosslinked with titania

Silva, Elisângela P. da; Guilherme, Marcos R.; Garcia, Francielle P.; Nakamura, Celso Vataru; Cardozo‐Filho, Lúcio; Alonso, Christian Gonçalves; Rubira, Adley F.; Kunita, Marcos H.

doi:10.1039/c5ra27865a

Cited by 50 publications

(17 citation statements)

References 36 publications

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“…The modification mechanism of polysaccharides with GMA was systematically analyzed in studies by Guilherme et al (2005), Guilherme et al (2012) and Silva et al (2016). The 1 H RMN and FTIR spectra showed that it reacts with GMA by epoxide ring-opening mechanism in a forward and irreversible reaction pathway and these results meet with those of the literature.…”

Section: Characterization Of Algmasupporting

confidence: 74%

“…(4)) supported such findings providing additional insight into burst release. Upon addition of SBA there was a decrease in values of k w , which was associated with the reduction of initial burst release, given that k w is related to the constant of release velocity (Silva et al, 2016).…”

Section: Studies On Water Transportmentioning

confidence: 98%

“…Such a system shows better biological and thermal, mechanical proprieties than pure HG did, making nanocomposite an ideal candidate for use in the biomedicine and pharmacy, such as controlled release and targeted delivery of drugs. Inorganic nanoparticles can minimize the burst release of HGs (high drug diffusion at early times) (Huang et al, 2015;Kerh, 2016;Silva et al, 2016). Materials which have been proven to be effective in the biomedicine include oxides (Liao et al, 2015;Hezaveh & Muhamad, 2013;Zare-Akbari et al, 2016), clay minerals (Gaharwar, Dammu, Canter, Wu & Schmidt, 2011;Liang et al, 2012;Topuz, Bartneck & Tacke, 2017;Wang et al, 2010), nanoparticles of silver (García-Astrain et al, 2015) and silica (Gaharwar, Rivera, Wu, Chan, & Schmidt, 2013;Panic et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Bionanocomposites based on mesoporous silica and alginate for enhanced drug delivery

Lima

Kupfer

Moisés

et al. 2018

Carbohydrate Polymers

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This work reports the preparation, the characterization and the prednisolone release profile of biocompatible hydrogel nanocomposites containing mesoporous silica (SBA) and alginate as a biomaterial for enhanced drug delivery with reduced burst effect and improved mechanical properties. Such systems, which were prepared using specific SBA/alginate-crosslinking chemistry, exhibited interconnecting pore hybrid network owing to both mesoporous silica and hydrogel characteristics. Activated SBA was shown to be a determinant factor in inhibiting initial burst by nearly 90% and the drug was released with minimal burst kinetics. The nanoparticles reduced the movements of polymer chains, affecting macromolecular relaxation, and the distribution of mesoporous silica within the hydrogel made drug release into surrounding liquid less favorable. The proposed systems are biocompatible with human immortalized RWPE-1 prostatic epithelial cells. This report offers an approach of up-to-date interest for the development of advanced biomaterials for further physiological and pathological applications.

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Section: Characterization Of Algmasupporting

confidence: 74%

Section: Studies On Water Transportmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Bionanocomposites based on mesoporous silica and alginate for enhanced drug delivery

Lima

Kupfer

Moisés

et al. 2018

Carbohydrate Polymers

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“…The studies in this field were performed only for very limited classes of drugs, and now required further attention. Although research on nanocomposites based on nanocellulose and inorganic nanoparticles is exponentially growing, there are a few reports that have been published on the synthesis of titania–nanocellulose composites for drug delivery [ 27 , 28 , 29 , 30 ]. Inspired by our previous work [ 29 , 30 ], we continued our investigation in the field of developing transdermal drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Drug Delivery Patches Based on Spherical Cellulose Nanocrystals and Colloid Titania—Synthesis and Antibacterial Properties

et al. 2018

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Spherical cellulose nanocrystal-based hybrids grafted with titania nanoparticles were successfully produced for topical drug delivery. The conventional analytical filter paper was used as a precursor material for cellulose nanocrystals (CNC) production. Cellulose nanocrystals were extracted via a simple and quick two-step process based on first the complexation with Cu(II) solution in aqueous ammonia followed by acid hydrolysis with diluted H2SO4. Triclosan was selected as a model drug for complexation with titania and further introduction into the nanocellulose based composite. Obtained materials were characterized by a broad variety of microscopic, spectroscopic, and thermal analysis methods. The drug release studies showed long-term release profiles of triclosan from the titania based nanocomposite that agreed with Higuchi model. The bacterial susceptibility tests demonstrated that released triclosan retained its antibacterial activity against Escherichia coli and Staphylococcus aureus. It was found that a small amount of titania significantly improved the antibacterial activity of obtained nanocomposites, even without immobilization of model drug. Thus, the developed hybrid patches are highly promising candidates for potential application as antibacterial agents.

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“…Some of these are considered to be the case of thixotropic behavior because of the recovery of the microstructure of the liquid to its initial state. It will always require a non-zero time and the recovery of viscosity is very rapid 18 .…”

Section: A Shear Thinning Property Of Injectablementioning

confidence: 99%

Untitled

2020

IJPSR

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The aim of a pharmaceutical product is to obtain excellent therapeutic and favorable treatment. Controlled drug release coatings have been around for more than 50 years and their performance has increased significantly since the beginning. The main drawbacks of the controlled drug delivery system are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance and non-specific targeting. To overcome this disadvantage, the researcher focused on controlled drug delivery system Injectable hydrogels. It is an emerging trend in the field of biomaterial drug delivery systems. Injectable Hydrogel overcomes the limitation of a pre-formed hydrogel, as they are injected with minimum invasive procedure into target sites and used for irregularly shaped sites. The recent studies of injectable hydrogels for the drug delivery applications suggested that multi-functional injectable hydrogels are capable of entrapping and systematically delivering the multiple therapeutic agents like drugs and macromolecules. The Injectable hydrogel shows shear thinning property when injected into the body. In this review, various aspects of Injectable hydrogel like introduction, Properties, preparation methods, drug loading and drug release strategies and applications of injectable hydrogels were discussed.

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Drug release profile and reduction in the in vitro burst release from pectin/HEMA hydrogel nanocomposites crosslinked with titania

Abstract: Hydrogel nanocomposites of pectin, HEMA and titania for Vit-B12 controlled release with reduced initial release burst were prepared. A reduction of up to ca. 60% was observed.

Cited by 50 publications

References 36 publications

Bionanocomposites based on mesoporous silica and alginate for enhanced drug delivery

Bionanocomposites based on mesoporous silica and alginate for enhanced drug delivery

Hybrid Drug Delivery Patches Based on Spherical Cellulose Nanocrystals and Colloid Titania—Synthesis and Antibacterial Properties

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