2018
DOI: 10.1002/advs.201801380
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One‐Step Generation of a Drug‐Releasing Hydrogel Microarray‐On‐A‐Chip for Large‐Scale Sequential Drug Combination Screening

Abstract: Large‐scale screening of sequential drug combinations, wherein the dynamic rewiring of intracellular pathways leads to promising therapeutic effects and improvements in quality of life, is essential for personalized medicine to ensure realistic cost and time requirements and less sample consumption. However, the large‐scale screening requires expensive and complicated liquid handling systems for automation and therefore lowers the accessibility to clinicians or biologists, limiting the full potential of sequen… Show more

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Cited by 35 publications
(14 citation statements)
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“…In addition, these polymeric microparticles are designed to have the shape code on their surface for use in multiplexed bioassays (Supplementary Figure S2). Multiplexed bioassays using shape-encoded microparticles enable the simultaneous detection and quantitation of multiple secreted proteins in a single microwell [21][22][23]. Thus, shape-encoded microparticles with 1D chains of magnetic nanoparticles are capable of using both magnetic attraction and magnetic rotating, which can result in diverse functional advantages in comprehensive bioassays (Figure 1b).…”
Section: The Principle and The Fabrication Of Magnetically Rotating Microparticles With Magnetization Patterningmentioning
confidence: 99%
“…In addition, these polymeric microparticles are designed to have the shape code on their surface for use in multiplexed bioassays (Supplementary Figure S2). Multiplexed bioassays using shape-encoded microparticles enable the simultaneous detection and quantitation of multiple secreted proteins in a single microwell [21][22][23]. Thus, shape-encoded microparticles with 1D chains of magnetic nanoparticles are capable of using both magnetic attraction and magnetic rotating, which can result in diverse functional advantages in comprehensive bioassays (Figure 1b).…”
Section: The Principle and The Fabrication Of Magnetically Rotating Microparticles With Magnetization Patterningmentioning
confidence: 99%
“…NGS can be used on these platforms to measure changes in gene expression profiles after treatment with the drug candidates. For example, Song et al introduced massively parallel drug screening biochips that can measure the effects of sequential drug treatments 54 . The platform is composed of a cell-biochip with multiple microwells seeded with cells.…”
Section: Future Biochips For Ngs Applicationsmentioning
confidence: 99%
“…AI technologies are driven by new ML algorithms, advances in computational power, and ever-increasing experimental data ( Bazoon et al., 2002 ; Pasquier and Hamodrakas, 2009 ). Advanced biotechnologies such as next-generation sequencing ( Dijk et al., 2014 ; Kim, 2019 ), cryo-electron microscopy, high-throughput screening ( Shin et al., 2016 ), medical digitization, and internet-of-things infrastructure ( Adrian et al., 1984 ; Atzori et al., 2010 ; Cai et al., 2019 ; Dubochet et al., 1988 ; Feng et al., 2012 ; Gupta et al., 2009 ; Li et al., 2013 ; Song et al, 2019 ) provide high-quality Big Data for the application of ML-based drug development. ML algorithms can be roughly divided into three kinds: unsupervised, supervised, and reinforced ( Ertel, 2017 ; Figueiredo and Jain, 2002 ; Kaelbling et al., 1996 ; Le, 2013 ; Piotr et al., 2006 ; Radford et al., 2015 ; Sahami, 1997 ; Sasakawa et al., 2010 ; Turian et al., 2010 ; Wang et al., 2019 ; Zhu and Goldberg, 2009 ).…”
Section: Introductionmentioning
confidence: 99%