One-stage lumbopelvic fixation in the treatment of lumbosacral junction tuberculosis

Zhang, Xu; Wang, Xiyang; Shen, Xiongjie; Luo, Chengke; Wu, Ping; Zeng, Hao

doi:10.1007/s00586-015-3863-8

Cited by 21 publications

(32 citation statements)

References 26 publications

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“…For instance, miR-524-5p suppressed the growth and invasion of GC cells [27]. 10 0 10 1 10 2 10 3 10 4 10 0 10 1 10 2 10 3 10 4 10 0 10 1 10 2 10 3 10 4 10 0 10 1 10 2 10 3 10 4 10 0 10 1 10 2 10 3 10 4 Annexin V-FITC MiR-216b was found downregulated in human GC cells, which could inhibit proliferation and cell cycle progression by targeting HDACB [28]. Also, miR-429 functioned as a tumor suppressor in GC cells, downregulating the oncogene FSCN1 [29].…”

Section: Discussionmentioning

confidence: 97%

MiR-135b-5p promotes viability, proliferation, migration and invasion of gastric cancer cells by targeting Krüppel-like factor 4 (KLF4)

Chen¹,

Gao²,

Gao³

et al. 2020

aoms

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Introduction: The expression of MiR-135b-5p was up-regulated while Krüppel-like factor 4 (KLF4) expression was extremely low in human gastric carcinoma (GC) tissues. This study aimed to explore the role of miR-135b-5p in GC cells and its influence on various cell capacity and viability by targeting KLF4. Material and methods: The dual-luciferase reporter assay was first performed and the target relationship between miR-135b-5p and KLF4 was confirmed. Then three GC cell lines and the human normal gastric epithelial cell line (GES1) were analyzed for the expression level of miR-135b-5p and KLF4 mRNA by RT-qPCR. The BGC-823 GC cell line was chosen for subsequent assays. Results: The expression of miR-135b-5p and KLF4 was manipulated via transfection. The changes of proliferation, invasion, migration, viability, cycle and apoptosis of GC cells were evaluated by MTS, colony formation assay, transwell assay, wound healing assay and flow cytometry assay, respectively. Overexpression of MiR-135b-5p enhanced viability, proliferation, invasion and migration of GC cells, increased cell viability and reduced cell apoptosis. Replenishing of KLF4 functioned oppositely. Conclusions: The inhibitory effects of ectopic KLF4 could be attenuated by co-transfection of miR-135b-5p. Collective data suggested that miR-135b-5p has a tumor-promoting role in GC cells via downregulating KLF4. Hence, inhibition of miR-135b-5p could be valuable for treatment of gastric cancer.

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Section: Discussionmentioning

confidence: 97%

MiR-135b-5p promotes viability, proliferation, migration and invasion of gastric cancer cells by targeting Krüppel-like factor 4 (KLF4)

Chen¹,

Gao²,

Gao³

et al. 2020

aoms

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“…The common advantages of the anterior approach are as follows: there is no destruction of the posterior structures and a single incision by the linea alba can significantly reduce the muscle damage; an extensive discectomy and several implants can restore disc height and correct the segmental lordosis; moreover, this approach can also offer more favorable biomechanical conditions for bone fusion; a direct access to the lesion and a direct reconstruction can facilitate the focal debridement and nerve decompression; this approach offers the best view of disc space compared with other procedures, which can decrease the surgical damage to blood vessels, ureters, and nerves; if the psoas or iliac abscess was flowed, this procedure allows the surgeon to remove it directly and thereby effectively prevent TB recurrence; in contrast, this may constitute a restriction for the 1-stage posterior approach [19] ; (6) the short operative time and the short hospital stay can reduce the financial burden of patients.…”

Section: Discussionmentioning

confidence: 99%

Application of anterior debridement and reconstruction with anatomical screw-plate fixation for lumbosacral tuberculosis

Wang

Chen²,

Yan³

et al. 2017

Medicine

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This study aimed to determine the efficacy and safety of anterior debridement and reconstruction with anatomical screw-plate fixation in patients with lumbosacral junction tuberculosis (TB).A total of 48 patients (30 males and 18 females) diagnosed with lumbosacral junction TB were included in this study. All patients underwent surgery in our institution from January 2008 to July 2014, using anterior debridement and reconstruction with anatomical screw-plate. Outcome data were evaluated before and after surgery and included lumbosacral angle, Frankel classification, bone fusion, and visual analog scale (VAS) scores.All patients were then followed up for an average of 49.4 months (range, 24–96 months). The mean lumbosacral angle improved from 8.36° ± 5.92° pre-operation to 22.38° ± 4.52° post-operation and 21.13° ± 3.73° during the final follow-up (both P < .05). Solid vertebral fusion was achieved in all patients after 7.6 months on average (range, 6–12 months). No severe complications appeared during operation and post-operation. Neurological performance and VAS scores were significantly improved compared with pre-operation (P < .05).Following standard anti-TB chemotherapy, anterior debridement and reconstruction with anatomical screw-plate fixation may be a feasible and effective therapeutical option for lumbosacral junction TB. This procedure can result in satisfactory bone fusion and deformity correction, and effectively restore lumbosacral junction stability.

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“…Though it is generally accepted that an anterior approach allows direct access to the infected tissues and sufficient debridement, 3 the risk of injury to the vasculature is high due to the abundant arteries and veins anterior to the lumbar spine, and it is difficult to operate in the lower lumbar spine. 16 Given the successful use of posterior debridement to treat lumbar spinal tuberculosis, 22 we believed it is also appropriate to use this method to treat lumbar postoperative spondylodiscitis. To remove pathogens as thoroughly as possible, we adopted a closed irrigation and drainage technology to wash the disc space persistently, which is typically used in the treatment of osteomyelitis and joint infections.…”

Section: Discussionmentioning

confidence: 99%

One-stage posterior debridement and fusion combined with irrigation and drainage for the treatment of postoperative lumbar spondylodiscitis

Zhang

et al. 2018

Acta Orthopaedica et Traumatologica Turcica

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ObjectiveThe aim of this study was to evaluate the clinical outcomes of one-stage posterior debridement, interbody fusion, and instrumentation, combined with irrigation and drainage, for treating lumbar spondylodiscitis.MethodsThe study included 23 patients (13 male and 10 female, mean age: 45 years) who had posterior debridement, interbody fusion, and instrumentation, followed by continuous closed irrigation and drainage for lumbar postoperative spondylodiscitis. The visual analog scale, Oswestry disability index, and lumbar lordosis angle were assessed before and after surgery to evaluate the clinical outcome.ResultsThe mean follow-up time was 27 (24–36) months. All patients tolerated the procedure well, and there were no instances of spondylodiscitis recurrence, though a dorsal dermal sinus developed in one patient after surgery. Infection was eliminated, as evidenced by the normalization of the erythrocyte sedimentation rates and C-reactive protein levels. The mean visual analog scale scores were significantly decreased after the operation. The mean lumbar lordosis angle before surgery was 21.61 ± 6.88° and the angle at the final follow-up was 31.61 ± 4.24°. The mean Oswestry disability index scores improved significantly both after the operation and at the follow-up visits (p < 0.05). Bone union was confirmed in all patients at a mean of 8.6 months post-operation, though this was not achieved until 2 years post-operation in one patient. All 3 patients who had neurological deficits showed great improvement at the last follow-up.ConclusionSurgical management using one-stage posterior debridement, interbody fusion, and instrumentation, followed by continuous closed irrigation and drainage, might be an effective treatment option for lumbar postoperative spondylodiscitis.Level of evidenceLevel IV, Therapeutic study.

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One-stage lumbopelvic fixation in the treatment of lumbosacral junction tuberculosis

Abstract: Our results suggest that one-stage posterior debridement, interbody fusion, lumbopelvic fixation, and postural drainage can be an effective and feasible treatment option for lumbosacral junction tuberculosis, offering fewer complications and a better quality of life.

Cited by 21 publications

References 26 publications

MiR-135b-5p promotes viability, proliferation, migration and invasion of gastric cancer cells by targeting Krüppel-like factor 4 (KLF4)

MiR-135b-5p promotes viability, proliferation, migration and invasion of gastric cancer cells by targeting Krüppel-like factor 4 (KLF4)

Application of anterior debridement and reconstruction with anatomical screw-plate fixation for lumbosacral tuberculosis

One-stage posterior debridement and fusion combined with irrigation and drainage for the treatment of postoperative lumbar spondylodiscitis

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