One species of Korean Wikstroemia ( Thymelaeaceae ) : W. ganpi ( Sieb. et Zucc. ) Maxim.

Hong, Hang Hwa; Im, Hyoung Tak; Hong, Sung Gak

doi:10.11110/kjpt.1999.29.4.391

Cited by 2 publications

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“…Maxim. is a deciduous shrub of genus the Wikstroemia of the Thymelaeaceae family, and is endemic in Australia, Japan, and the southern region of South Korea [ 21 ]. Plants of the genus, Wikstroemia , have traditionally been used as source for making paper in East Asia.…”

Section: Introductionmentioning

confidence: 99%

Wikstroemiaganpi Extract Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Interleukin-4 in 2,4-Dinitrochlorobenzene-Induced SKH-1 Hairless Mice

Jegal

Park

et al. 2021

Molecules

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Plants of the genus Wikstroemia are used in Chinese traditional medicine to treat inflammatory diseases, such as arthritis, bronchitis, and pneumonia. The present study was designed to determine whether Wikstroemia ganpi (Siebold and Zucc.) Maxim. offers a potential means of treating 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Symptoms such as redness, edema, and keratinization in AD mice induced by DNCB were alleviated by the co-application of an ethanolic extract of W. ganpi for 2 weeks. The severity of skin barrier function damage was evaluated by measuring TEWL (transepidermal water loss). TEWLs of DNCB sensitized mouse dorsal skin were reduced by the application of a W. ganpi ethanolic extract, and skin hydration was increased. In addition, the infiltration of inflammatory cells into the dermis was significantly reduced, as were blood levels of IgE and IL-4, which play an important role in the expression of AD. The results of this experiment suggest that W. ganpi is a potential therapeutic agent for AD.

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Section: Introductionmentioning

confidence: 99%