One-pot synthesis of vancomycin-encapsulated ZIF-8 nanoparticles as multivalent and photocatalytic antibacterial agents for selective-killing of pathogenic gram-positive bacteria

Recent advances in metal–organic frameworks and their composites for the phototherapy of skin wounds

“…Due to the unstable coordination bonds, MOFs can be degraded into small molecules and discharged out of the body. 62 Benefiting from these characteristics, MOF-based materials contribute to a wide range of applications in the removal of pesticides from wastewater, 63,64 the removal of pharmaceutical residues, 65–67 catalysis, 31 luminescence, 68 gas capture, storage and separation, 69,70 sensing, 71 solar energy capture, 72 energy storage, 70 electron and ion conduction and so on. In particular, the application of MOFs in the biomedical field has attracted extensive attention, mainly reflected in drug delivery, 73 biomimetic enzymes, 74 bioimaging, 75 cancer therapy, 76 antibacterial therapy, 77 and biomarker detection 78 (Table 1).…”

“…29 It has been reported that MOFs serve as ideal candidates for antibacterial treatment and wound healing, which can be applied in wound treatment by releasing bactericidal metal ions 30 and loading bactericidal drugs. 31 Besides, MOFs also produce reactive oxygen species (ROS) to achieve a bactericidal effect through photoelectric therapy, photothermal therapy and ultrasonic therapy. 32,33 In this review, the current progress of MOFs and their composites for the phototherapy of skin wounds is presented.…”

Embedding an extraordinary amount of gemifloxacin antibiotic in ZIF-8 framework with one-step synthesis and measurement of its H2O2-sensitive release and potency against infectious bacteria

“…So far, various cargoes have been loaded on ZIF-8, and most of the drugs on it have been used for cancer therapy. 18,19,23 Cases of loading of antibiotics on ZIF-8, such as ciprofloxacin 24 and vancomycin, 25 have been reported. Fluoroquinolones are a class of broad-spectrum antibiotics that generally have good pharmacokinetics.…”

Synthesis and Encapsulation of Ajuga parviflora Extract with Zeolitic Imidazolate Framework-8 and Their Therapeutic Action against G+ and G– Drug-Resistant Bacteria

“…It exhibits excellent thermal stability up to 550 °C in an N 2 atmosphere and no structural degradation in boiling organic solvents and water at 50 °C for 7 days . For gases like hydrogen and methane, ZIF-8 is increasingly gaining importance to be employed as a storage medium and as a high-capacity adsorbent to meet various separation needs in thin-film devices, catalysis, biomedical imaging, and drug delivery . Antibiotics such as vancomycin, doxorubicin (DOX), ciprofloxacin, gentamicin, and others have been encapsulated using ZIF-8 .…”

“…22 For gases like hydrogen and methane, ZIF-8 is increasingly gaining importance to be employed as a storage medium 23 and as a high-capacity adsorbent to meet various separation needs 24 in thin-film devices, 25 catalysis, 26 biomedical imaging, 27 and drug delivery. 28 Antibiotics such as vancomycin, doxorubicin (DOX), 29 ciprofloxacin, 30 gentamicin, and others have been encapsulated using ZIF-8. 31 Cu 2+ -doped ZIF-8 loaded with curcumin was shown to alter its synergy with phenolic antioxidants, enhancing its antibacterial action.…”