One-pot synthesis of the organomodified layered double hydroxides - glibenclamide biocompatible nanoparticles

Leão, Amanda Damasceno; Alvarez‐Lorenzo, Carmen; Sobrinho, José Lamartine Soares

doi:10.1016/j.colsurfb.2020.111055

Cited by 20 publications

(3 citation statements)

References 109 publications

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“…Although the concentration of positive ions is greater than that of negative ions, the zeta‐potential of the measured particles is still negative because the negative charges of the nanoparticles are still greater than the sum of the positive charges. As detected in our experiment, the zetapotential of Eudragit‐Based BP ‐EO NPs was negative potential, which was consistent with literature reports (Leão et al, 2020; Mohammadi et al, 2019). Furthermore, BP ‐EO NPs showed an accelerated, sustained release at pH 6.5, which is similar to the tumor environment.…”

Section: Discussionsupporting

confidence: 93%

Preparation of Black pepper (Piper nigrum L.) essential oil nanoparticles and its antitumor activity on triple negative breast cancer in vitro

Zhang

Qiu²,

Sun

et al. 2022

Journal of Food Biochemistry

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The active compounds isolated from Black pepper have anticancer effects, but the bioactivity of Black pepper essential oil (BP‐EO) is rarely studied. BP‐EO has poor stability and a suitable dose form should be prepared for in vivo delivery. Triple negative breast cancer (TNBC) has attracted more and more attention due to its high mitotic index, high metastasis rate and poor prognosis. In this study, the composition of BP‐EO was analyzed by gas chromatography–mass spectrometry (GC–MS), and nanoparticles (NPs) loaded with BP‐EO were prepared by nanoprecipitation method using Eudragit L100 as a carrier. We investigated the preparation, characterization, stability and in vitro release of nanoparticles. MTT assay, cell wound healing, Transwell invasion assay and Western blot were used to study the anti‐tumor effect and mechanism of MDA‐MB‐231 cells. The GC–MS analysis identified a total of 33 compounds among which alkenes account for 63.55%. The prepared BP‐EO NPs exhibited nanoscale morphology, good stability and pH‐responsive and sustained release character which is suitable for in vivo delivery. BP‐EO NPs significantly inhibited the proliferation, migration and invasion of MDA‐MB‐231 cells. Furthermore, BP‐EO NPs significantly inhibited the expressions of Wnt and β‐catenin and significantly activated the expression of GSK‐3β in MDA‐MB‐231 cells. Therefore, BP‐EO NPs prepared in this study provide a new effective strategy for the treatment of TNBC. Practical applications Black pepper is rich in essential oil and has excellent antioxidant and antibacterial activities. However, the anti‐tumor activity of BP‐EO has not been studied. In this study, we found that BP‐EO has excellent anticancer activity. To achieve effective encapsulation of black pepper essential oil and an excellent anti‐triple negative breast cancer activity, nanoparticles loaded with BP‐EO were prepared using Eudragit L100 as the carrier by the nanoprecipitation method. The in vitro study revealed that BP‐EO NPs inhibited proliferation, migration and invasion of MDA‐MB‐231 cells via inhibiting the Wnt/β‐Catenin signaling pathway. This study provides new ideas and innovations for the treatment of invasive triple negative breast cancer in the future. At the same time, we will further reveal the application potential, pharmacokinetic characteristics and precise mechanism of BP‐EO NPs in vivo in subsequent studies.

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Section: Discussionsupporting

confidence: 93%

Preparation of Black pepper (Piper nigrum L.) essential oil nanoparticles and its antitumor activity on triple negative breast cancer in vitro

Zhang

Qiu²,

Sun

et al. 2022

Journal of Food Biochemistry

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“…LDHs are well-known anion exchanging materials [36] and have numerous applications in different areas such as electrochemistry [37], drug delivery [38] or heterogeneous catalysis [39,40] due to their several advantages such as ease of preparation [41], chemical stability [42], resistance against mechanical energy [43] and compatibility with biological systems [44]. By utilizing their anion exchanger capacities, various structures of different interlayer galleries or outer surfaces, morphologies [45,46], dimensions [47] and compositions [48] were produced, exhibiting wider physicochemical properties compared to their parent structures.…”

Section: Basic Features Of Ldhsmentioning

confidence: 99%

Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications

Pavlović

Szerlauth

Muráth

et al. 2022

Advanced Drug Delivery Reviews

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“…Further increase in ller content to 5 wt% enhanced the thermal stability at T max by 4°C for r-HDPE, leading to an increase of residue at high temperature (500°C-600°C) due to the complete collapse of clay structure and the formation of metal oxides in the endothermic decomposition of LDHs layers, thus delaying the nal decomposition of the nanocomposites, Figs. 10 and 11 [39]. The addition of 1 wt% of SA to 3 wt% and 5 wt% of clay improved the T max by 5°C and 2°C, respectively due to the nano-dispersion of ller in the matrix.…”

Section: Thermo Gravimetric Analyses (Tga)mentioning

confidence: 95%

The effect of laboratory synthesized and modified layered double hydroxides on recycled and neat high density polyethylene matrix properties using stearic acid as an interface modifier

DERRADJ,

Zoukrami,

GUERBAA

et al. 2023

Preprint

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In this research, the effect of layered double hydroxides (LDHs) as nanofillers on recycled and neat high density polyethylene (HDPE) properties was investigated. The synthesis of unmodified and modified LDHs was achieved via one-pot hydrothermal co-precipitation method at a constant pH. The nanofillers were organically modified by using sodium dodecyl sulphate (SDS) as surfactant and stearic acid (SA) as an interface modifier in order to overcome the incompatibility problems with HDPE Matrix. The nanocomposites were prepared by melt blending and compression molding with 3 and 5 wt% filler loading rate. Thermal, structural, and morphological tests were conducted to analyze the performance of the LDHs and the compatibilizing agent on the dispersion, and on the properties of the studied composites. Results revealed that 3 wt% of unmodified LDHs filler reinforced all physical and mechanical properties of the obtained nanocomposites based on recycled and neat HDPE matrix. When the weight of LDHs was increased to 5 wt%, morphological observations showed that SA has prevented the aggregation of LDHs particles and improved their dispersion into the recycled HDPE matrix. The physical and mechanical properties of the composite materials were enhanced dramatically with the addition of stearic acid as interface modifier into the recycled polymeric matrix compared to SDS intercalating which improved only the izod impact strength. The formulations of r-HDPE/3%LDH and r-HDPE/5%LDH-1%SA were found to be the ideal combinations which could provide novel mechanical applications to meet industrial requirements at higher scale.

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One-pot synthesis of the organomodified layered double hydroxides - glibenclamide biocompatible nanoparticles

Cited by 20 publications

References 109 publications

Preparation of Black pepper (Piper nigrum L.) essential oil nanoparticles and its antitumor activity on triple negative breast cancer in vitro

Preparation of Black pepper (Piper nigrum L.) essential oil nanoparticles and its antitumor activity on triple negative breast cancer in vitro

Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications

The effect of laboratory synthesized and modified layered double hydroxides on recycled and neat high density polyethylene matrix properties using stearic acid as an interface modifier

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