One-pot synthesis of sulphur-bridged rhenium containing molecular cubanes: Spectroscopic and structural characterisation

“…Supramolecular self-assembly of transition-metal precursors and multidentate pyridyl ligands has led to the development of numerous types of metallasupramolecular architectures . Metallasupramolecules are advantageous over organic supramolecules because of their tailorable architecture consisting of organic ligands and metal-containing units tethered via linkers and spacers. − Currently, research based on the coordination-driven self-assembly of transition-metal-containing multicomponent systems is actively pursued because of the fascinating architectural shapes (triangle, square, rectangle, pentagon, hexagon, prism, cube, and cage) and the diverse applications they offer in various fields such as molecular recognition, supramolecular devices, chemotherapy, cytotoxicity, asymmetric catalysis, chemosensing, and host–guest chemistry. − …”

Section: Introductionmentioning

confidence: 99%

Selenolato-Bridged Manganese(I)-Based Dinuclear Metallacycles as Potential Anticancer Agents and Photo-CORMs

et al. 2019

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Selenolato-bridged manganese(I)-based dinuclear metallacycles [{(CO)3Mn(μ-SeC6H5)2Mn(CO)3}(μ-L)] (1–4) were achieved in a single-step process by the self-assembly of dimanganese decacarbonyl, diphenyl diselenide, and flexible ditopic ester-functionalized pyridyl ligands [1, L = o-phenylene diisonicotinate (pdi); 2, L = 1,6-hexanediyl di-4-pyridine carboxylate (hdp); 3, L = 4-pyridine carboxylic acid diethylene glycol diester (pcadgd); 4, L = 4-pyridine carboxylic acid triethylene glycol diester (pcatgd)]. Synthesis of a series of selenolato-bridged dinuclear Mn(I)-based metallacycles was facilitated via oxidative addition of C6H5Se–SeC6H5 to (CO)5Mn–Mn(CO)5 with simultaneous coordination of flexible ditopic pyridyl linkers in an orthogonal fashion. The metallacycles were characterized by IR, UV–vis, NMR, and electrospray ionization-mass spectroscopic techniques and elemental analysis. Solid-state structural elucidation of 3 was carried out using single-crystal X-ray diffraction methods. In addition, anticancer activity studies were carried out for compounds 2–4 with various cancer cell lines. Furthermore, compound 3 was probed to evaluate its potential CO-releasing property using myoglobin assay.

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Self‐Assembled Multinuclear Complexes Incorporating ^99mTc

Frei

Mokolokolo

Bolliger

et al. 2018

Chemistry A European J

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Multinuclear complexes or clusters are rarely investigated in medicinal inorganic chemistry although they represent structural intermediates between molecules and nanomaterials. We present in this report two strategies towards Tc-containing clusters. In a pre-assembly approach, the preformed but incomplete cluster fragment [Re (μ -OH) (μ -OH)(CO) ] reacts with [ Tc(CO) ] to the highly stable [ TcRe (μ -OH) (CO) ] cube. The same structure self-assembles when reacting the mononuclear Re and Tc precursors in one pot. Integrating the coordinating OH groups from Schiff bases in this concept leads straight to dinuclear, mixed-metal complexes of the type [ TcRe(μ -O^N-R ) (CO) ] in quantitative yields. Both strategies are unprecedented and open a future path towards clusters, incorporating a Tc radiolabel while being decorated with targeting or cytotoxic moieties.

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One-pot synthesis of sulphur-bridged rhenium containing molecular cubanes: Spectroscopic and structural characterisation

Cited by 7 publications

References 61 publications

Tricarbonylrhenium(I) Complexes with N‐Heterocyclic Thiones and Selenols

Tricarbonylrhenium(I) Complexes with N‐Heterocyclic Thiones and Selenols

Selenolato-Bridged Manganese(I)-Based Dinuclear Metallacycles as Potential Anticancer Agents and Photo-CORMs

Self‐Assembled Multinuclear Complexes Incorporating ^99mTc

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One-pot synthesis of sulphur-bridged rhenium containing molecular cubanes: Spectroscopic and structural characterisation

Cited by 7 publications

References 61 publications

Tricarbonylrhenium(I) Complexes with N‐Heterocyclic Thiones and Selenols

Tricarbonylrhenium(I) Complexes with N‐Heterocyclic Thiones and Selenols

Selenolato-Bridged Manganese(I)-Based Dinuclear Metallacycles as Potential Anticancer Agents and Photo-CORMs

Self‐Assembled Multinuclear Complexes Incorporating 99mTc

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Self‐Assembled Multinuclear Complexes Incorporating ^99mTc