One-pot synthesis of highly hemocompatible polyurethane/polyethersulfone composite membranes

Wang, Chen; Wang, Qian; Li, Shuangsi; Zhang, Man; Zhao, Weifeng; Sun, Shudong; Zhao, Changsheng

doi:10.1007/s00289-017-1922-5

Cited by 6 publications

(5 citation statements)

References 59 publications

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“…Table 6 presents the comparative analysis of prepared PHB/kaolin nanocomposites with other composites reported in various literatures 1,67,91–97 . The present study demonstrates the reinforcement of PHB material with kaolin (nanomaterial) and PEG (antimicrobial agent) which is cheaper, and significantly reduces inflammatory reaction, and improves hemocompatibility of nanocomposites.…”

Section: Resultsmentioning

confidence: 57%

“…The PLA/Curcumin (1%) nanofibers, PLCL, and PAN/CPEI composites displayed PT values of 12.94, 11.8, and 14.8 s, respectively, while APTT values were 36.91, 28.2, and 36.1 s 67,93,94 . The pure PAN, PES‐PU, PSF/PES, and CA/CS/SCP composites exhibit the C3 complement activation of 140, 500, 425, and 700 ng/ml, respectively 37,95–97 . With regard to literature data, the biocompatibility results obtained in this work are comparable or even better.…”

Section: Resultsmentioning

confidence: 96%

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Fabrication and properties of polyhydroxybutyrate/kaolin nanocomposites and evaluation of their biocompatibility for biomedical applications

Ankush

Pugazhenthi

Vasanth

2021

J of Applied Polymer Sci

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The polyhydroxybutyrate biopolymer nanocomposites (C1–C10) were fabricated by solvent casting method with different loading of kaolin and polyethylene glycol. Scanning electron microscopy showed that the microstructure of the composites varied with different kaolin loading. X‐ray diffraction and Fourier transform infrared spectroscopy analysis confirm the presence of kaolin in the polymer matrix due to the intercalation and formation of hydrogen bond. The contact angle of the nanocomposites decreased with increasing kaolin loading indicating an improvement in wettability of the nanocomposites. Thermogravimetric and differential scanning calorimetry analysis showed that the Tmax and Tm of the nanocomposites increased with increasing kaolin loading. The mechanical property of the nanocomposite fabricated with 10 wt% kaolin (C10) was found to have identical mechanical property with natural bone that was selected as an optimum nanocomposite. The nanocomposite showed prolonged blood clotting time exhibiting anticoagulant nature of the nanocomposite. Moreover, low protein adsorption (168 ± 8 μg/cm2), suppressed platelet adhesion (75 ± 2 × 109 platelets/cm2) and less complement activation (118 ± 5 mg/dl for C3 and 658 ± 5 mg/dl for C4) showed the improvement in surface properties of the nanocomposite. In vitro bioactivity studies revealed the formation of hydroxyapatite layer on the surface of the nanocomposites. Eventually, the nanocomposites (C10) showed no cytotoxic effect on MG‐63 cells as tested through MTT assay and it is biologically safe.

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Section: Resultsmentioning

confidence: 57%

Section: Resultsmentioning

confidence: 96%

Fabrication and properties of polyhydroxybutyrate/kaolin nanocomposites and evaluation of their biocompatibility for biomedical applications

Ankush

Pugazhenthi

Vasanth

2021

J of Applied Polymer Sci

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“…Polyethersulfone (PES) has been widely applied in various fields such as water purification and hemodialysis due to its good mechanical property, thermal stability, chemical resistance, and blood compatibility. , Thus, it may be a suitable support material for urease immobilization and can be further applied to remove urea from blood. Urease can be immobilized onto matrixes by several methods, such as adsorption, entrapment, and covalent grafting. − Adsorption is a process of accumulating urease on solid supports depending on the intermolecular interactions; although it is used as a typical method, there exists a problem that urease might leach from the solid supports.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Safe and Effective Removal of Urea by Urease-Immobilized, Carboxyl-Functionalized PES Beads with Good Reusability and Storage Stability

Zhang

Wang

et al. 2019

ACS Omega

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Urea is one of the uremic toxins threating people’s health. Herein, we prepared a kind of urease-immobilized beads to remove urea, which exhibited good hemocompatibility and high removal efficiency. Urease was covalently grafted onto carboxyl-group-functionalized polyethersulfone beads, which were previously prepared by in situ cross-linking polymerization and phase inversion methods. The urease-immobilized beads had sufficient blood compatibility with low protein adsorption amount, undiminished clotting times, low hemolysis ratio, and suppressed complement activation and contact activation. Furthermore, the urease-immobilized beads showed good urea removal ability with a urea removal amount of 75.1 mg/g after incubating in 80 mg/dL urea solution for 480 min. In addition, the prepared urease-immobilized beads could maintain urea removal activity after being used for five cycles and showed satisfied activity even when stored for 15 days in phosphate buffer saline solution. Thus, the urease-immobilized beads may meet the potential application demand for safe and effective blood detoxification.

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“…Due to the good chemical resistance, thermal and hydrolytic stability, mechanical and film‐forming properties, polyether sulfone (PES) membrane has been widely used in water purification, membrane distillation, and hemodialysis . However, the bacteria infection and the subsequent formation of biofilm on PES membrane surface would cause decline of membrane performance and lifetime .…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Antibacterial Surfaces Switching from Bacterial Adhesion to Bacterial Repulsion

Wang

Feng

et al. 2018

Macro Materials & Eng

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/mame.201700590. Antibacterial SurfacesHerein, ene-functionalized dopamine is first coated onto a polyether sulfone membrane surface to introduce double bonds as anchoring sites for hydrogel film. Then, a hydrogel film is synthesized and simultaneously attached onto the membrane via photoinduced crosslinking copolymerization of N-isopropylacrylamide (NIPAAm) and methacryloxyethyltrimethyl ammonium chloride. The thickness of the hydrogel film can be well-controlled ranging from the nano meter to micrometer scales, which can retain the permeability of the membrane. Water contact angle and swelling tests demonstrate that the modified membrane shows thermoresponsive surface wettability. The quaternary ammonium salts in the hydrogel film can kill the attached bacteria efficiently and the dead bacteria can be detached by reducing the temperature below the lower critical solution temperature of poly(NIPAAm). The modified membrane also shows improved hemocompatibility, confirmed by prolonged clotting time and low hemolysis ratio. Hence, the designed thermoresponsive antibacterial hydrogel film with enhanced hemocompatibility has great potential to be applied in biomedical areas.

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One-pot synthesis of highly hemocompatible polyurethane/polyethersulfone composite membranes

Cited by 6 publications

References 59 publications

Fabrication and properties of polyhydroxybutyrate/kaolin nanocomposites and evaluation of their biocompatibility for biomedical applications

Fabrication and properties of polyhydroxybutyrate/kaolin nanocomposites and evaluation of their biocompatibility for biomedical applications

Safe and Effective Removal of Urea by Urease-Immobilized, Carboxyl-Functionalized PES Beads with Good Reusability and Storage Stability

Thermoresponsive Antibacterial Surfaces Switching from Bacterial Adhesion to Bacterial Repulsion

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